Beta-Arrestins in the Treatment of Heart Failure Related to Hypertension: A Comprehensive Review [PDF]
Pharmaceutics, 2021 Heart failure (HF) is a complicated clinical syndrome that is considered an increasingly frequent reason for hospitalization, characterized by a complex therapeutic regimen, reduced quality of life, and high morbidity.
Ahmed Rakib +10 more
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Beta-Arrestins and Receptor Signaling in the Vascular Endothelium [PDF]
Biomolecules, 2020 The vascular endothelium is the innermost layer of blood vessels and is a key regulator of vascular tone. Endothelial function is controlled by receptor signaling through G protein-coupled receptors, receptor tyrosine kinases and receptor serine ...
Claudia Lee +5 more
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Nedd4 E3 ligase and beta-arrestins regulate ubiquitination, trafficking, and stability of the mGlu7 receptor [PDF]
eLife, 2019 The metabotropic glutamate receptor 7 (mGlu7) is a class C G protein-coupled receptor that modulates excitatory neurotransmitter release at the presynaptic active zone. Although post-translational modification of cellular proteins with ubiquitin is a key
Sanghyeon Lee +6 more
doaj +2 more sources
GLP-1 Receptor Signaling and Oral Dysfunction: A Narrative Review on the Mechanistic Basis of Semaglutide-Related Oral Adverse Effects [PDF]
BiologyThis review addresses the growing concern of oral side effects, particularly dry mouth, associated with semaglutide, a glucagon-like peptide-1 receptor agonist (GLP-1RA) widely used for diabetes and obesity. A literature search of PubMed/MEDLINE, Scopus,
Milena Barać, Jelena Roganović
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Beta-arrestins operate an on/off control switch for focal adhesion kinase activity [PDF]
Cellular and Molecular Life Sciences, 2020 Alexandre Beautrait +2 more
exaly +2 more sources
c-Src regulates Akt signaling in response to ghrelin via beta-arrestin signaling-independent and -dependent mechanisms. [PDF]
PLoS ONE, 2009 The aim of the present study was to identify the signaling mechanisms to ghrelin-stimulated activation of the serine/threonine kinase Akt. In human embryonic kidney 293 (HEK293) cells transfected with GHS-R1a, ghrelin leads to the activation of Akt ...
Maria Lodeiro +4 more
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Mammalian α arrestins link activated seven transmembrane receptors to Nedd4 family e3 ubiquitin ligases and interact with β arrestins. [PDF]
PLoS ONE, 2012 The complement of fungal cell surface proteins is widely regulated by ubiquitination of membrane proteins, which results in their endocytosis and vacuolar degradation.
Fortune F Shea +4 more
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Quantification of beta adrenergic receptor subtypes in beta-arrestin knockout mouse airways. [PDF]
PLoS ONE, 2015 In allergic asthma Beta 2 adrenergic receptors (β2ARs) are important mediators of bronchorelaxation and, paradoxically, asthma development. This contradiction is likely due to the activation of dual signaling pathways that are downstream of G proteins or
Akhil Hegde +2 more
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The incidence of candidate binding sites for β-arrestin in Drosophila neuropeptide GPCRs.
PLoS ONE, 2022 To support studies of neuropeptide neuromodulation, I have studied beta-arrestin binding sites (BBS's) by evaluating the incidence of BBS sequences among the C terminal tails (CTs) of each of the 49 Drosophila melanogaster neuropeptide GPCRs.
Paul H Taghert
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Impaired recruitment of Grk6 and beta-Arrestin 2 causes delayed internalization and desensitization of a WHIM syndrome-associated CXCR4 mutant receptor. [PDF]
PLoS ONE, 2009 WHIM (warts, hypogammaglobulinemia, infections, and myelokatexis) syndrome is a rare immunodeficiency syndrome linked to heterozygous mutations of the chemokine receptor CXCR4 resulting in truncations of its cytoplasmic tail.
Peter J McCormick +4 more
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