Results 31 to 40 of about 749,005 (154)

Beta-arrestin 1 regulation of reward-motivated behaviors and glutamatergic function. [PDF]

PLoS ONE, 2017
The two highly homologous non-visual arrestins, beta-arrestin 1 and 2, are ubiquitously expressed in the central nervous system, yet knowledge of their disparate roles is limited.
Nitish Mittal, Ani Minasyan, Nicole Romaneschi, Joshua K Hakimian, Gabriel Gonzalez-Fernandez, Ralph Albert, Nina Desai, Ian A Mendez, Timothy Schallert, Sean B Ostlund, Wendy Walwyn   +10 more
doaj   +1 more source

β-arrestin-2 is an essential regulator of pancreatic β-cell function under physiological and pathophysiological conditions

Nature Communications, 2017
Beta-arrestins have key roles in development and metabolic functions as euglycaemic control and insulin sentitivity. Here Zhuet al. show that beta-arrestin-2 regulates insulin secretion and glucose tolerance in mice by promoting CAMKII functions in beta ...
Lu Zhu, Joana Almaça, Prasanna K. Dadi, Hao Hong, Wataru Sakamoto, Mario Rossi, Regina J. Lee, Nicholas C. Vierra, Huiyan Lu, Yinghong Cui, Sara M. McMillin, Nicole A. Perry, Vsevolod V. Gurevich, Amy Lee, Bryan Kuo, Richard D. Leapman, Franz M. Matschinsky, Nicolai M. Doliba, Nikhil M. Urs, Marc G. Caron, David A. Jacobson, Alejandro Caicedo, Jürgen Wess   +22 more
doaj   +1 more source

Role of beta-arrestin 2 downstream of dopamine receptors in the basal ganglia

Frontiers in Neuroanatomy, 2011
Multifunctional scaffolding protein beta-arrestins (βArr) and the G protein receptor kinases (GRK) are involved in the desensitization of several G protein coupled-receptors (GPCR).
Thomas eDel'Guidice, Morgane eLemasson, Jean-Martin eBeaulieu   +2 more
doaj   +1 more source

Targeting of beta-arrestin2 to the centrosome and primary cilium: role in cell proliferation control. [PDF]

PLoS ONE, 2008
The primary cilium is a sensory organelle generated from the centrosome in quiescent cells and found at the surface of most cell types, from where it controls important physiological processes.
Anahi Molla-Herman, Cedric Boularan, Rania Ghossoub, Mark G H Scott, Anne Burtey, Marion Zarka, Sophie Saunier, Jean-Paul Concordet, Stefano Marullo, Alexandre Benmerah   +9 more
doaj   +1 more source

Regulation of the Cardiac Potassium Channel Kir2.1 by the alpha-arrestins

, 2020
1. Kir2.1 is a mammalian potassium channel that is linked to numerous cardiac arrhythmias when it is unable to function or be trafficked correctly. 2.
Ceara K. McAtee (8729687), Allyson F. O'Donnell (201306), Jeffrey L Brodsky (55005), Marcel Bruchez (3882238), Adam V. Kwiatkowski (8729690), Natalie A. Hager (8729683)   +5 more
core   +1 more source

Differential β-arrestin2 requirements for constitutive and agonist-induced internalization of the CB1 cannabinoid receptor [PDF]

, 2013
CB1 cannabinoid receptor (CB1R) undergoes both constitutive and agonist-induced internalization, but the underlying mechanisms of these processes and the role of beta-arrestins in the regulation of CB1R function are not completely understood.
Boros, Eszter, Hunyady, L., Gyombolai, Pál, Boros, E., Turu, G., Turu, Gábor, Gyombolai, P., Hunyady, László   +7 more
core   +1 more source

A new inhibitor of the β-arrestin/AP2 endocytic complex reveals interplay between GPCR internalization and signalling

Nature Communications, 2017
Beta-arrestins play central roles in the mechanisms regulating GPCR signalling and trafficking. Here the authors identify a selective inhibitor of the interaction between β-arrestin and the β2-adaptin subunit of the clathrin adaptor protein AP-2, which ...
Alexandre Beautrait, Justine S. Paradis, Brandon Zimmerman, Jenna Giubilaro, Ljiljana Nikolajev, Sylvain Armando, Hiroyuki Kobayashi, Lama Yamani, Yoon Namkung, Franziska M. Heydenreich, Etienne Khoury, Martin Audet, Philippe P. Roux, Dmitry B. Veprintsev, Stéphane A. Laporte, Michel Bouvier   +15 more
doaj   +1 more source

Interaction of Protease-Activated Receptor 2 with G Proteins and Beta-Arrestin 1 Studied by Bioluminescence Resonance Energy Transfer

Frontiers in Endocrinology, 2013
G protein-coupled receptors (GPCRs) are well recognized as being able to activate several signaling pathways through the activation of different G proteins as well as other signaling proteins such as beta-arrestins.
Mohammed Akli eAyoub, Jean-Philippe R Pin   +1 more
doaj   +1 more source

Distinct phosphorylation sites on the ghrelin receptor, GHSR1a, establish a code that determines the functions of ß-arrestins

, 2016
The growth hormone secretagogue receptor, GHSR1a, mediates the biological activities of ghrelin, which includes the secretion of growth hormone, as well as the stimulation of appetite, food intake and maintenance of energy homeostasis.
R. Nogueiras (7691495), Andrew B. Tobin (7589429), M. Lodeiro (7691492), M. Bouzo-Lorenzo (7691486), A. J. Butcher (7691504), F. F. Casanueva (7691498), M. Castro (677347), Y. Pazos (7691501), I. Santo-Zas (7691489), J. P. Camiña (7691507)   +9 more
core   +7 more sources

Multifaceted role of beta-arrestins in inflammation

, 2014
The overall goal of the study is to understand the role of β-arrestins (intracellular scaffolding cell signaling proteins) in inflammation and pathogenesis of sepsis and colitis using mouse models.
Sharma, Deepika
core   +1 more source