Results 11 to 20 of about 4,050 (178)
Role of beta-arrestin 2 downstream of dopamine receptors in the basal ganglia [PDF]
Frontiers in Neuroanatomy, 2011 Multifunctional scaffolding protein beta-arrestins (βArr) and the G protein receptor kinases (GRK) are involved in the desensitization of several G protein coupled-receptors (GPCR).
Thomas eDel'Guidice +2 more
doaj +3 more sources
Beta-arrestin 1 regulation of reward-motivated behaviors and glutamatergic function. [PDF]
PLoS ONE, 2017 The two highly homologous non-visual arrestins, beta-arrestin 1 and 2, are ubiquitously expressed in the central nervous system, yet knowledge of their disparate roles is limited.
Nitish Mittal +10 more
doaj +6 more sources
The constitutively active V2 receptor mutants conferring NSIAD are weakly sensitive to agonist and antagonist regulation. [PDF]
PLoS ONE, 2009 Patients having the nephrogenic syndrome of inappropriate antidiuresis present either the R137C or R137L V2 mutated receptor. While the clinical features have been characterized, the molecular mechanisms of functioning of these two mutants remain elusive.
Julie Tenenbaum +10 more
doaj +1 more source
Biomolecules, 2023 The heteromer composed of dopamine D1 and D3 receptors (D1R–D3R) has been defined as a structure able to trigger Erk1/2 and Akt signaling in a G protein-independent, beta-arrestin 1-dependent way that is physiologically expressed in the ventral striatum ...
Federica Bono +7 more
doaj +1 more source
Physiological and pharmacological implications of beta-arrestin regulation [PDF]
Pharmacology & Therapeutics, 2009 G protein-coupled receptor-targeted drug discovery as well as "compound reassessment" requires the utilization of diverse screens to determine agonist efficacies and potencies beyond the scope of ligand binding and G protein coupling. Such efforts have arisen from extensive studies, both in cellular and animal models, demonstrating that these seven ...
Cullen L, Schmid, Laura M, Bohn
openaire +2 more sources
β-arrestin2 in infiltrated macrophages inhibits excessive inflammation after myocardial infarction. [PDF]
PLoS ONE, 2013 Beta-arrestins (β-arrestin1 and β-arrestin2) are known as cytosolic proteins that mediate desensitization and internalization of activated G protein-coupled receptors.
Kenji Watari +4 more
doaj +1 more source
On the origins of arrestin and rhodopsin
BMC Evolutionary Biology, 2008 Background G protein coupled receptors (GPCRs) are the most numerous proteins in mammalian genomes, and the most common targets of clinical drugs. However, their evolution remains enigmatic.
Alvarez Carlos E
doaj +1 more source
Beta-Arrestin-Mediated Signaling in the Heart
Circulation Journal, 2008 Beta-arrestin is a multifunctional adapter protein well known for its role in G-protein-coupled receptor (GPCR) desensitization. Exciting new evidence indicates that beta-arrestin is also a signaling molecule capable of initiating its own G-protein-independent signaling at GPCRs.
Patel, Priyesh A. +2 more
openaire +3 more sources
Polypeptide variants of beta-arrestin and arrestin3
Journal of Biological Chemistry, 1993 Retinal arrestin (S-antigen) inactivates the phototransduction cascade by binding to light-activated phosphorylated rhodopsin and thereby "arresting" coupling to the G protein transducin. beta-Arrestin (beta arr), a ubiquitous arrestin homolog, acts analogously to desensitize the beta 2-adrenergic receptor by disrupting Gs receptor interaction.
R, Sterne-Marr +6 more
openaire +2 more sources
Triphenylmethane Dye Activation of Beta-Arrestin
Biochemistry, 2013 β-Arrestins regulate G protein-coupled receptor signaling as competitive inhibitors and protein adaptors. Low molecular weight biased ligands that bind receptors and discriminate between the G protein dependent arm and β-arrestin, clathrin-associated arm of receptor signaling are considered therapeutically valuable as a result of this distinctive ...
Barak, Larry S. +5 more
openaire +2 more sources