Beta-Arrestins and Receptor Signaling in the Vascular Endothelium [PDF]
Biomolecules, 2020 The vascular endothelium is the innermost layer of blood vessels and is a key regulator of vascular tone. Endothelial function is controlled by receptor signaling through G protein-coupled receptors, receptor tyrosine kinases and receptor serine ...
Claudia Lee +5 more
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Beta-Arrestins in the Treatment of Heart Failure Related to Hypertension: A Comprehensive Review [PDF]
Pharmaceutics, 2021 Heart failure (HF) is a complicated clinical syndrome that is considered an increasingly frequent reason for hospitalization, characterized by a complex therapeutic regimen, reduced quality of life, and high morbidity.
Ahmed Rakib +10 more
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Mammalian α arrestins link activated seven transmembrane receptors to Nedd4 family e3 ubiquitin ligases and interact with β arrestins. [PDF]
PLoS ONE, 2012 The complement of fungal cell surface proteins is widely regulated by ubiquitination of membrane proteins, which results in their endocytosis and vacuolar degradation.
Fortune F Shea +4 more
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Nedd4 E3 ligase and beta-arrestins regulate ubiquitination, trafficking, and stability of the mGlu7 receptor [PDF]
eLife, 2019 The metabotropic glutamate receptor 7 (mGlu7) is a class C G protein-coupled receptor that modulates excitatory neurotransmitter release at the presynaptic active zone. Although post-translational modification of cellular proteins with ubiquitin is a key
Sanghyeon Lee +6 more
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Configurational diversity of metabotropic glutamate receptor complexes with beta-arrestins [PDF]
Nature CommunicationsBeta-arrestins (β-arrs) are cytosolic proteins which mediate G protein-coupled receptor (GPCR) desensitization, endocytosis, and signaling. Despite the widespread physiological roles of β-arr coupling, the molecular basis of GPCR/β-arr interaction has ...
Dagan C. Marx +12 more
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Structural basis of active state coupling of metabotropic glutamate receptor 8 to beta-arrestins [PDF]
Nature CommunicationsMetabotropic glutamate receptors (mGluRs) are prototypical, dimeric family C G protein-coupled receptors (GPCR) that perform crucial modulatory roles throughout the nervous system.
Dagan C. Marx +11 more
doaj +2 more sources
GLP-1 Receptor Signaling and Oral Dysfunction: A Narrative Review on the Mechanistic Basis of Semaglutide-Related Oral Adverse Effects [PDF]
BiologyThis review addresses the growing concern of oral side effects, particularly dry mouth, associated with semaglutide, a glucagon-like peptide-1 receptor agonist (GLP-1RA) widely used for diabetes and obesity. A literature search of PubMed/MEDLINE, Scopus,
Milena Barać, Jelena Roganović
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Beta‐Arrestin‐2 Binds to Nucleolar Organizing Regions With P2X7 Receptor Stimulation and During Cell Division [PDF]
FASEB JBeta‐Arrestin‐2 but not Beta‐Arrestin‐1 can accumulate in the nucleolus and come in close contact with the Nucleolar Organizing Regions during two distinct processes: P2X7 receptor stimulation (A) and cell division (B). Both seem to be due to loss of nuclear membrane barrier that keeps Beta‐arrestin‐2 out of the nucleus.
Gümüştaş T +4 more
europepmc +2 more sources
Regulation of the orexin 1 receptor by beta-arrestins [PDF]
, 2004 The orexin 1 receptor was identified as an orphan G protein-coupled receptor (GPCR) in 1998 (Sakurai et ah, 1998). There is great interest in the orexin receptor system since it is involved in the control of feeding and energy metabolism (Sakurai et al ...
Milasta, Sandra
core +7 more sources
c-Src regulates Akt signaling in response to ghrelin via beta-arrestin signaling-independent and -dependent mechanisms. [PDF]
PLoS ONE, 2009 The aim of the present study was to identify the signaling mechanisms to ghrelin-stimulated activation of the serine/threonine kinase Akt. In human embryonic kidney 293 (HEK293) cells transfected with GHS-R1a, ghrelin leads to the activation of Akt ...
Maria Lodeiro +4 more
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