Results 21 to 30 of about 4,050 (178)

Beta-Arrestin Biased Signaling at a Class a GPCR: Modeling the ORG27569 Induced CB1/Beta-Arrestin 1 Complex [PDF]

Biophysical Journal, 2015
The CB1 allosteric modulator, ORG27569 (ORG), is an inverse agonist of the G-protein signaling pathway and agonist of the beta-arrestin-1 pathway (Ahn et.al JBC 2013). The intracellular conformational change associated with arrestin-biased signaling is outward movement of the intracellular TMH7/HX8 elbow region away from TMH2 (Rahmeh et.al PNAS 2012 ...
Hurst, Dow P., Lynch, Diane L., Shore, Derek M., Pitman, Michael C., Reggio, Patricia H.   +4 more
openaire   +1 more source

β-arrestin-2 is an essential regulator of pancreatic β-cell function under physiological and pathophysiological conditions

Nature Communications, 2017
Beta-arrestins have key roles in development and metabolic functions as euglycaemic control and insulin sentitivity. Here Zhuet al. show that beta-arrestin-2 regulates insulin secretion and glucose tolerance in mice by promoting CAMKII functions in beta ...
Lu Zhu, Joana Almaça, Prasanna K. Dadi, Hao Hong, Wataru Sakamoto, Mario Rossi, Regina J. Lee, Nicholas C. Vierra, Huiyan Lu, Yinghong Cui, Sara M. McMillin, Nicole A. Perry, Vsevolod V. Gurevich, Amy Lee, Bryan Kuo, Richard D. Leapman, Franz M. Matschinsky, Nicolai M. Doliba, Nikhil M. Urs, Marc G. Caron, David A. Jacobson, Alejandro Caicedo, Jürgen Wess   +22 more
doaj   +1 more source

Targeting of beta-arrestin2 to the centrosome and primary cilium: role in cell proliferation control. [PDF]

PLoS ONE, 2008
The primary cilium is a sensory organelle generated from the centrosome in quiescent cells and found at the surface of most cell types, from where it controls important physiological processes.
Anahi Molla-Herman, Cedric Boularan, Rania Ghossoub, Mark G H Scott, Anne Burtey, Marion Zarka, Sophie Saunier, Jean-Paul Concordet, Stefano Marullo, Alexandre Benmerah   +9 more
doaj   +1 more source

A new inhibitor of the β-arrestin/AP2 endocytic complex reveals interplay between GPCR internalization and signalling

Nature Communications, 2017
Beta-arrestins play central roles in the mechanisms regulating GPCR signalling and trafficking. Here the authors identify a selective inhibitor of the interaction between β-arrestin and the β2-adaptin subunit of the clathrin adaptor protein AP-2, which ...
Alexandre Beautrait, Justine S. Paradis, Brandon Zimmerman, Jenna Giubilaro, Ljiljana Nikolajev, Sylvain Armando, Hiroyuki Kobayashi, Lama Yamani, Yoon Namkung, Franziska M. Heydenreich, Etienne Khoury, Martin Audet, Philippe P. Roux, Dmitry B. Veprintsev, Stéphane A. Laporte, Michel Bouvier   +15 more
doaj   +1 more source

Interaction of Protease-Activated Receptor 2 with G Proteins and Beta-Arrestin 1 Studied by Bioluminescence Resonance Energy Transfer

Frontiers in Endocrinology, 2013
G protein-coupled receptors (GPCRs) are well recognized as being able to activate several signaling pathways through the activation of different G proteins as well as other signaling proteins such as beta-arrestins.
Mohammed Akli eAyoub, Jean-Philippe R Pin   +1 more
doaj   +1 more source

Identification of beta-arrestin-1 as a diagnostic biomarker in lung cancer [PDF]

British Journal of Cancer, 2018
Distinguishing lung adenocarcinoma (ADC) from squamous cell carcinoma (SCC) has a tremendous therapeutic implication. Sometimes, the commonly used immunohistochemistry (IHC) markers fail to discriminate between them, urging for the identification of new diagnostic biomarkers.We performed IHC on tissue microarrays from two cohorts of lung cancer ...
El-Khoury, Victoria, Béland, Mélanie, Schritz, Anna, Kim, Sang-Yoon, Nazarov, Petr V., Gaboury, Louis, Sertamo, Katriina, Bernardin, François, Batutu, Roxane, Antunes, Laurent, Bennett, Catherine W., Faÿs, François, Berchem, Guy, Kim, Yeoun Jin   +13 more
openaire   +2 more sources

Lack of beta-arrestin signaling in the absence of active G proteins [PDF]

Nature Communications, 2018
Abstract G protein-independent, arrestin-dependent signaling is a paradigm that broadens the signaling scope of G protein-coupled receptors (GPCRs) beyond G proteins for numerous biological processes. However, arrestin signaling in the collective absence of functional G proteins has never been demonstrated. Here we achieve a state of “
Grundmann M., Merten N., Malfacini D., Inoue A., Preis P., Simon K., Ruttiger N., Ziegler N., Benkel T., Schmitt N. K., Ishida S., Muller I., Reher R., Kawakami K., Inoue A., Rick U., Kuhl T., Imhof D., Aoki J., Konig G. M., Hoffmann C., Gomeza J., Wess J., Kostenis E.   +23 more
openaire   +4 more sources

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Untangling Inositol (Pyro)Phosphate Biology Through Emerging Technologies

Advanced Science, EarlyView.
Inositol (pyro)phosphates represent a vital class of intracellular messengers that govern multiple biological processes. The last decade has experienced a surge of interest in the functions of this class of signaling molecules, primarily due to the introduction of several innovative analytical technologies.
Adolfo Saiardi, Mengsi Lu, Yue Zhang, Anuj Shukla, An‐Li Andrea Ko, Henning J. Jessen   +5 more
wiley   +1 more source

Single‐Cell Transcriptomics and Metabolomics Reveal Glutamate Dehydrogenase as a Central Regulator of Nitrogen Metabolic Remodeling During Alkalinity Adaptation in Crustaceans

Advanced Science, EarlyView.
Single‐cell transcriptomics reveals the cellular response of Macrobrachium hainanense to carbonate alkalinity stress. Alkalinity stress impairs branchial ammonia excretion, induces mitochondrial dysfunction, and drives cell‐type‐specific changes in gills and hemocytes.
Yiting Jin, Zhimin Lv, Chao Bian, Qibin Yang, Na Zhou, Jianguang Qin, Shengming Sun   +6 more
wiley   +1 more source