Quantification of beta adrenergic receptor subtypes in beta-arrestin knockout mouse airways. [PDF]
PLoS ONE, 2015 In allergic asthma Beta 2 adrenergic receptors (β2ARs) are important mediators of bronchorelaxation and, paradoxically, asthma development. This contradiction is likely due to the activation of dual signaling pathways that are downstream of G proteins or
Akhil Hegde +2 more
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The incidence of candidate binding sites for β-arrestin in Drosophila neuropeptide GPCRs
PLoS ONE, 2022 To support studies of neuropeptide neuromodulation, I have studied beta-arrestin binding sites (BBS’s) by evaluating the incidence of BBS sequences among the C terminal tails (CTs) of each of the 49 Drosophila melanogaster neuropeptide GPCRs.
Paul H. Taghert
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Impaired recruitment of Grk6 and beta-Arrestin 2 causes delayed internalization and desensitization of a WHIM syndrome-associated CXCR4 mutant receptor. [PDF]
PLoS ONE, 2009 WHIM (warts, hypogammaglobulinemia, infections, and myelokatexis) syndrome is a rare immunodeficiency syndrome linked to heterozygous mutations of the chemokine receptor CXCR4 resulting in truncations of its cytoplasmic tail.
Peter J McCormick +4 more
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Scaffolding of Mitogen-Activated Protein Kinase Signaling by β-Arrestins
, 2022 β-arrestins were initially identified to desensitize and internalize G-protein-coupled receptors (GPCRs). Receptor-bound β-arrestins also initiate a second wave of signaling by scaffolding mitogen-activated protein kinase (MAPK) signaling ...
Yeonjin Han +3 more
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The constitutively active V2 receptor mutants conferring NSIAD are weakly sensitive to agonist and antagonist regulation. [PDF]
PLoS ONE, 2009 Patients having the nephrogenic syndrome of inappropriate antidiuresis present either the R137C or R137L V2 mutated receptor. While the clinical features have been characterized, the molecular mechanisms of functioning of these two mutants remain elusive.
Julie Tenenbaum +10 more
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Biomolecules, 2023 The heteromer composed of dopamine D1 and D3 receptors (D1R–D3R) has been defined as a structure able to trigger Erk1/2 and Akt signaling in a G protein-independent, beta-arrestin 1-dependent way that is physiologically expressed in the ventral striatum ...
Federica Bono +7 more
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The Two β-Arrestins Regulate Distinct Metabolic Processes: Studies with Novel Mutant Mouse Models
, 2022 The two β-arrestins (β-arrestin-1 and -2; alternative names: arrestin-2 and -3, respectively) are well known for their ability to inhibit signaling via G protein-coupled receptors.
Jürgen Wess
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On the origins of arrestin and rhodopsin
BMC Evolutionary Biology, 2008 Background G protein coupled receptors (GPCRs) are the most numerous proteins in mammalian genomes, and the most common targets of clinical drugs. However, their evolution remains enigmatic.
Alvarez Carlos E
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β-arrestin2 in infiltrated macrophages inhibits excessive inflammation after myocardial infarction. [PDF]
PLoS ONE, 2013 Beta-arrestins (β-arrestin1 and β-arrestin2) are known as cytosolic proteins that mediate desensitization and internalization of activated G protein-coupled receptors.
Kenji Watari +4 more
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Desensitization, internalization, and signaling functions of beta-arrestins demonstrated by RNA interference. [PDF]
, 2003 Beta-arrestins bind to activated G protein-coupled receptor kinase-phosphorylated receptors, which leads to their desensitization with respect to G proteins, internalization via clathrin-coated pits, and signaling via a growing list of "scaffolded ...
Garrison, Tiffany Runyan +4 more
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