Results 51 to 60 of about 31,759 (252)
ARRESTIN-MEDIATED EFFECTOR ACTIVATION
, 2023 Nonvisual arrestins (arrestin-2 and arrestin-3) regulate a wide range of signaling events, most notably when bound to active G protein-coupled receptors (GPCRs).
Perez, Ivette
core +1 more source
Molecules, 2020 We report data on the structural dynamics of the neuropeptide Y (NPY) G-protein-coupled receptor (GPCR) type 1 (Y1R), a typical representative of class A peptide ligand GPCRs, using a combination of solid-state NMR and molecular dynamics (MD) simulation.
Alexander Vogel +9 more
doaj +1 more source
QR code model: a new possibility for GPCR phosphorylation recognition
Cell Communication and Signaling, 2022 G protein-coupled receptors (GPCRs) are the largest family of membrane proteins in the human body and are responsible for accurately transmitting extracellular information to cells. Arrestin is an important member of the GPCR signaling pathway.
Hao Chen +3 more
doaj +1 more source
On the origins of arrestin and rhodopsin [PDF]
BMC Evolutionary Biology, 2008 G protein coupled receptors (GPCRs) are the most numerous proteins in mammalian genomes, and the most common targets of clinical drugs. However, their evolution remains enigmatic. GPCRs are intimately associated with trimeric G proteins, G protein receptor kinases, and arrestins. We conducted phylogenetic studies to reconstruct the history of arrestins.
openaire +3 more sources
Ciliary Membrane Lipid Homeostasis in Health and Disease
Advanced Science, EarlyView.This review systematically delineates the distinct lipid landscapes of ciliary membranes, including the spatial organization of phosphoinositides, cholesterol, and sphingolipids. It elucidates how these lipids orchestrate ciliogenesis, signal transduction, and membrane dynamics in cilia beating, and highlights how their dysregulation drives ...
Zhenzhou Huang +3 more
wiley +1 more source
Frontiers in Physiology, 2020 Eyes morphologies may differ but those differences are not reflected at the molecular level. Indeed, the ability to perceive light is thought to come from the same conserved gene families: opsins and cryptochromes.
Morgane Bonadè +5 more
doaj +1 more source
Advanced Science, EarlyView.Administration of opioids activates ephrinB2‐EphB1 receptor signaling. Activated EphB1 receptors induce GRK2‐mediated phosphorylation of MOR at Ser375, which initiates the internalization of MOR and reduces opioid antinociception at the behavioral level. ABSTRACT Opioids are the primary treatment for severe pain in clinical practice.
Bo Peng +7 more
wiley +1 more source
The human GPCR nicotinic acid receptor 1 : heterologous overproduction in Pichia pastoris and the reconstitution of its complex with beta-Arrestin 1 in vivo and in vitro [PDF]
, 2007 Nicotinic acid has been used in the clinical treatment of elevated blood lipid levels for over 50 years. Although it has a beneficial effect on myocardial infarction and blood lipid profiles, its widespread use has been hampered by side effects such as ...
Griesbach, Jan
core
Chinese Journal of Lung Cancer, 2011 Background and objective Non-small cell lung cancer (NSCLC) with high morbidity and mortality is the most common types of lung cancer. beta-arrestin 2 is a kind of soluble protein regulating signal transduction mediated by G protein coupling receptor ...
Zhengqing WU +4 more
doaj +1 more source
Frontiers in Endocrinology, 2019 Initially identified as monomers, G protein-coupled receptors (GPCRs) can also form functional homo- and heterodimers that act as distinct signaling hubs for cellular signal integration.
Dany Fillion +5 more
doaj +1 more source