Results 1 to 10 of about 442,339 (288)

Development of a Heuristic Machine Analogy Method for Model Simplification With an Application to a Large‐Scale Model of Gi/Gs Signaling

CPT: Pharmacometrics & Systems Pharmacology
Model simplification is a process to simplify large‐scale mathematical models to enable easy applications such as simulation and parameter estimation.
Liang Yang, David Finlay, Michelle Glass, Stephen Duffull   +3 more
doaj   +1 more source

Loss of biased signaling at a G protein-coupled receptor in overexpressed systems.

PLoS ONE, 2023
G protein-coupled receptors (GPCRs) regulate cellular signaling pathways by coupling to two classes of transducers: heterotrimeric G proteins and β-arrestins.
Angus Li, Samuel Liu, Rennica Huang, Seungkirl Ahn, Robert J Lefkowitz   +4 more
doaj   +1 more source

The distribution of Dishevelled in convergently extending mesoderm [PDF]

, 2013
Convergent extension (CE) is a conserved morphogenetic movement that drives axial lengthening of the primary body axis and depends on the planar cell polarity (PCP) pathway.
Bretschneider, Till, Green, Jeremy B.A., Panousopoulou, Eleni, Tyson, Richard A. (Richard Anthony)   +3 more
core   +1 more source

The impossibility of non-signaling privacy amplification

, 2009
Barrett, Hardy, and Kent have shown in 2005 that protocols for quantum key agreement exist the security of which can be proven under the assumption that quantum or relativity theory is correct.
Hänggi, Esther, Renner, Renato, Wolf, Stefan   +2 more
core   +1 more source

Isoprenoids determine Th1/Th2 fate in pathogenic T cells, providing a mechanism of modulation of autoimmunity by atorvastatin. [PDF]

, 2006
3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase is a critical enzyme in the mevalonate pathway that regulates the biosynthesis of cholesterol as well as isoprenoids that mediate the membrane association of certain GTPases.
Dunn, Shannon E, Goldstein, Matthew J, Prod'homme, Thomas, Steinman, Lawrence, Weber, Martin S, Youssef, Sawsan, Zamvil, Scott S   +6 more
core   +1 more source

Get to grips with motivation: Slipping and gripping movements are biased by approach-avoidance context

Frontiers in Psychology, 2022
People are better at approaching appetitive cues signaling reward and avoiding aversive cues signaling punishment than vice versa. This action bias has previously been shown in approach-avoidance tasks involving arm movements in response to appetitive or
Sofie Johanna Nilsson, David Meder, Kristoffer Hougaard Madsen, Kristoffer Hougaard Madsen, Ivan Toni, Hartwig Roman Siebner, Hartwig Roman Siebner, Hartwig Roman Siebner   +7 more
doaj   +1 more source

Cell biological mechanisms of activity-dependent synapse to nucleus translocation of CRTC1 in neurons. [PDF]

, 2015
Previous studies have revealed a critical role for CREB-regulated transcriptional coactivator (CRTC1) in regulating neuronal gene expression during learning and memory. CRTC1 localizes to synapses but undergoes activity-dependent nuclear translocation to
Ch'ng, Toh Hean, DeSalvo, Martina, Lin, Peter, Martin, Kelsey C, Vashisht, Ajay, Wohlschlegel, James A   +5 more
core   +1 more source

Loads bias genetic and signaling switches in synthetic and natural systems.

PLoS Computational Biology, 2014
Biological protein interactions networks such as signal transduction or gene transcription networks are often treated as modular, allowing motifs to be analyzed in isolation from the rest of the network.
Samanthe M Lyons, Wenlong Xu, June Medford, Ashok Prasad   +3 more
doaj   +1 more source

Counterclockwise rotation of the flagellum promotes biofilm initiation in Helicobacter pylori

mBio
Motility promotes biofilm initiation during the early steps of this process: microbial surface association and attachment. Motility is controlled in part by chemotaxis signaling, so it seems reasonable that chemotaxis may also affect biofilm formation ...
Xiaolin Liu, Paphavee Lertsethtakarn, Vanessa T. Mariscal, Fitnat Yildiz, Karen M. Ottemann   +4 more
doaj   +1 more source

Critical Appraisal for Racial and Ethnic Equity in Clinical Prediction Models Extension: Development of a Critical Appraisal Tool Extension to Assess Racial and Ethnic Equity-Related Risk of Bias for Clinical Prediction Models

Health Equity, 2023
Introduction: Despite mounting evidence that the inclusion of race and ethnicity in clinical prediction models may contribute to health disparities, existing critical appraisal tools do not directly address such equity considerations.
doaj   +1 more source