Results 31 to 40 of about 6,937,440 (273)
Nature Communications, 2023 Signaling bias is the ability of a receptor to differentially activate downstream signaling pathways in response to different ligands. Bias investigations have been hindered by inconsistent results in different cellular contexts.
Daniel Wirth +2 more
doaj +1 more source
Signal Evolution: ‘Shaky’ Evidence for Sensory Bias [PDF]
Current Biology, 2016 A study of tropical crickets suggests that a twitchy response to ultrasonic bat calls has been co-opted for mate location. The neuroethological approach picks apart some surprising evolutionary steps that could inform the widespread occurrence of complex duetting behaviour.
Pascoal, Sonia +2 more
openaire +2 more sources
Neural Signals for the Detection of Unintentional Race Bias [PDF]
Psychological Science, 2004 We examined the hypothesis that unintentional race-biased responses may occur despite the activation of neural systems that detect the need for control. Participants completed a sequential priming task that induced race-biased responses on certain trials while electroencephalography was recorded. The error-related negativity (ERN) wave, a component of
David M, Amodio +5 more
openaire +2 more sources
Structural basis of glucocorticoid receptor signaling bias
Journal of Neuroendocrinology, 2022 Abstract Dissociation between the healthy and toxic effects of cortisol, a major stress‐responding hormone has been a widely used strategy to develop anti‐inflammatory glucocorticoids with fewer side effects. Such strategy falls short when treating brain disorders as timing and activity state within large‐scale neuronal networks ...
Jeanneteau, Freddy +2 more
openaire +4 more sources
Cellular Signalling, 2020 Opioid analgesics are elective for treating moderate to severe pain but their use is restricted by severe side effects. Signaling bias has been proposed as a viable means for improving this situation.
G. Piñeyro, Karim Nagi
semanticscholar +1 more source
Frontiers in Immunology, 2020 The dramatic female sex bias observed in human lupus is thought to be due, at least in part, to estrogens. Using mouse models, we have shown that estrogens, acting through estrogen receptor alpha (ERα) promote lupus development and contribute ...
Jared H. Graham +2 more
doaj +1 more source
Affective Bias Through the Lens of Signal Detection Theory [PDF]
Computational Psychiatry, 2020 Affective bias - a propensity to focus on negative information at the expense of positive information - is a core feature of many mental health problems. However, it can be caused by wide range of possible underlying cognitive mechanisms. Here we illustrate this by focusing on one particular behavioural signature of affective bias - increased tendency ...
Shannon M. Locke, Oliver J. Robinson
openaire +6 more sources
Frontiers in Pharmacology, 2019 Arrestin translocation and signaling have come to the fore of the G protein-coupled receptor molecular pharmacology field. Some receptor–arrestin interactions are relatively well understood and considered responsible for specific therapeutic or adverse ...
Mikkel Søes Ibsen +9 more
doaj +1 more source
Bias-inducing allosteric binding site in mu-opioid receptor signaling
SN Applied Sciences, 2021 G-protein-biased agonism of the mu-opioid receptor (μ-OR) is emerging as a promising strategy in analgesia. A deep understanding of how biased agonists modulate and differentiate G-protein-coupled receptors (GPCR) signaling pathways and how this is ...
Andrés F. Marmolejo-Valencia +2 more
doaj +1 more source