Results 31 to 40 of about 442,339 (288)
Structural basis of glucocorticoid receptor signaling bias
Journal of Neuroendocrinology, 2022 Abstract Dissociation between the healthy and toxic effects of cortisol, a major stress‐responding hormone has been a widely used strategy to develop anti‐inflammatory glucocorticoids with fewer side effects. Such strategy falls short when treating brain disorders as timing and activity state within large‐scale neuronal networks ...
Jeanneteau, Freddy +2 more
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Frontiers in Immunology, 2020 The dramatic female sex bias observed in human lupus is thought to be due, at least in part, to estrogens. Using mouse models, we have shown that estrogens, acting through estrogen receptor alpha (ERα) promote lupus development and contribute ...
Jared H. Graham +2 more
doaj +1 more source
Frontiers in Pharmacology, 2019 Arrestin translocation and signaling have come to the fore of the G protein-coupled receptor molecular pharmacology field. Some receptor–arrestin interactions are relatively well understood and considered responsible for specific therapeutic or adverse ...
Mikkel Søes Ibsen +9 more
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Bias-inducing allosteric binding site in mu-opioid receptor signaling
SN Applied Sciences, 2021 G-protein-biased agonism of the mu-opioid receptor (μ-OR) is emerging as a promising strategy in analgesia. A deep understanding of how biased agonists modulate and differentiate G-protein-coupled receptors (GPCR) signaling pathways and how this is ...
Andrés F. Marmolejo-Valencia +2 more
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Fine Tuning Muscarinic Acetylcholine Receptor Signaling Through Allostery and Bias
Frontiers in Pharmacology, 2021 The M1 and M4 muscarinic acetylcholine receptors (mAChRs) are highly pursued drug targets for neurological diseases, in particular for Alzheimer’s disease and schizophrenia.
Emma T. van der Westhuizen +7 more
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Environmental and Molecular Modulation of Motor Individuality in Larval Zebrafish
Frontiers in Behavioral Neuroscience, 2021 Innate behavioral biases such as human handedness are a ubiquitous form of inter-individual variation that are not strictly hardwired into the genome and are influenced by diverse internal and external cues.
John Hageter +11 more
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Towards a behavioral theory of bias in signal detection [PDF]
Perception & Psychophysics, 1981 A behavioral model for performance on signal-detection tasks is presented. It is based on a relation between response and reinforcement ratios which has been derived from both animal and human research on the distribution of behavior between concurrently available schedules of reinforcement.
D, McCarthy, M, Davison
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Confirmation bias and signaling in Downsian elections [PDF]
Journal of Public Economics, 2020 How do voters' behavioural biases affect political outcomes? We study this question in a model of Downsian electoral competition in which office-motivated candidates have private information about the benefits of policies, and voters may infer candidates' information from their electoral platforms.
Millner, Antony +2 more
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Molecular mechanism of biased signaling at the kappa opioid receptor
Nature Communications, 2023 Biased signaling in κ-opiod receptors (KOR) offer an attractive strategy for pain management. Here the authors identify determinants of KOR signaling bias using structural methods in combination with molecular dynamics simulations.
Amal El Daibani +13 more
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Affective Bias Through the Lens of Signal Detection Theory [PDF]
Computational Psychiatry, 2020 Affective bias - a propensity to focus on negative information at the expense of positive information - is a core feature of many mental health problems. However, it can be caused by wide range of possible underlying cognitive mechanisms. Here we illustrate this by focusing on one particular behavioural signature of affective bias - increased tendency ...
Shannon M. Locke, Oliver J. Robinson
openaire +6 more sources