Results 41 to 50 of about 442,339 (288)
Functional divergence in the role of N-linked glycosylation in smoothened signaling [PDF]
, 2015 The G protein-coupled receptor (GPCR) Smoothened (Smo) is the requisite signal transducer of the evolutionarily conserved Hedgehog (Hh) pathway. Although aspects of Smo signaling are conserved from Drosophila to vertebrates, significant differences have ...
A Helenius +83 more
core +3 more sources
Stratification bias in low signal microarray studies [PDF]
BMC Bioinformatics, 2007 When analysing microarray and other small sample size biological datasets, care is needed to avoid various biases. We analyse a form of bias, stratification bias, that can substantially affect analyses using sample-reuse validation techniques and lead to inaccurate results.
Brian J. Parker +2 more
openaire +4 more sources
Signaling Competence in Elections [PDF]
, 2013 We analyze how political candidates can signal their competence and show that polarization might be a way of doing this. For this purpose, we study a unidimensional Hotelling-Downs model of electoral competition in which a fraction of candidates have the
Honryo, Takakazu
core +2 more sources
A Review of the Therapeutic Potential of Recently Developed G Protein-Biased Kappa Agonists
Frontiers in Pharmacology, 2019 Between 2000 and 2005 several studies revealed that morphine is more potent and exhibits fewer side effects in beta-arrestin 2 knockout mice. These findings spurred efforts to develop opioids that signal primarily via G protein activation and do not, or ...
Kendall L. Mores +6 more
doaj +1 more source
Neurobiology of Disease, 2022 Schizophrenia is a psychiatric disorder that affects over 20 million people globally. Notably, schizophrenia is associated with decreased density of dendritic spines and decreased levels of d-serine, a co-agonist required for opening of the N-methyl-d ...
Deborah K. Park +6 more
doaj +1 more source
Bias in chemokine receptor signalling
Trends in Immunology, 2014 Chemokine receptors are widely expressed on a variety of immune cells and play a crucial role in normal physiology as well as in inflammatory and infectious diseases. The existence of 23 chemokine receptors and 48 chemokine ligands guarantees a tight control and fine-tuning of the immune system.
Zweemer, A.J.M. +3 more
openaire +4 more sources
Correcting the minimization bias in searches for small signals [PDF]
Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2003 We discuss a method for correcting the bias in the limits for small signals if those limits were found based on cuts that were chosen by minimizing a criterion such as sensitivity. Such a bias is commonly present when a "minimization" and an "evaluation" are done at the same time. We propose to use a variant of the bootstrap to adjust the limits.
Rolke, Wolfgang A., Lopez, Angel M.
openaire +2 more sources
Reporting and Assessing the Quality of Diagnostic Accuracy Studies for Cervical Cancer Screening and Management. [PDF]
, 2020 ObjectiveWe adapted the Quality Assessment of Diagnostic Accuracy Studies 2 (QUADAS-2) tool for studies of cervical cancer screening and management and used the adapted tool to evaluate the quality of studies included in a systematic review supporting ...
Clarke, Megan A +8 more
core
Functional selectivity of GPCR-directed drug action through location bias. [PDF]
, 2017 G-protein-coupled receptors (GPCRs) are increasingly recognized to operate from intracellular membranes as well as the plasma membrane. The β 2 -adrenergic GPCR can activate G s -linked cyclic AMP (G s -cAMP) signaling from endosomes.
Conti, Marco +6 more
core +3 more sources
REST/NRSF Knockdown Alters Survival, Lineage Differentiation and Signaling in Human Embryonic Stem Cells. [PDF]
, 2015 REST (RE1 silencing transcription factor), also known as NRSF (neuron-restrictive silencer factor), is a well-known transcriptional repressor of neural genes in non-neural tissues and stem cells.
Jan, Majib +4 more
core +3 more sources