Results 61 to 70 of about 442,339 (288)
Sources of bias in signals of pharmaceutical safety in pregnancy
Clinical and Investigative Medicine, 2010 Every year scores of new pharmaceuticals enter the market, almost never with human fetal safety data. Such data typically accumulate during the first years of clinical use, in the form of case reports, case series, prospective and retrospective cohorts and case control studies. All of these methods suffer from serious sources of bias, often leading to
Gideon, Koren, Sheri, Nickel
openaire +3 more sources
Linking proteins to signaling pathways for experiment design and evaluation. [PDF]
PLoS ONE, 2012 Biomedical experimental work often focuses on altering the functions of selected proteins. These changes can hit signaling pathways, and can therefore unexpectedly and non-specifically affect cellular processes.
Illés J Farkas +2 more
doaj +1 more source
Cell Reports, 2021 Summary: Drosophila melanogaster Down syndrome cell adhesion molecule (Dscam1) can generate 38,016 different isoforms through largely stochastic, yet highly biased, alternative splicing. These isoforms are required for nervous functions.
Weiling Hong +19 more
doaj +1 more source
Dividend Guidance to Manage Analyst Dividend Expectations [PDF]
, 2018 Using a sample of dividend payers from 12 European countries, we document that managers guide analyst dividend expectations to avoid reporting dividends below the consensus forecast. Specifically, we show that dividend guidance predicts (1) a substantial
Bilinski, P., Lyssimachou, D.
core +1 more source
Evaluation of Deviations Produced by Soft Tissue Fitting in Virtually Planned Orthognathic Surgery
Applied SciencesOrthognathic surgery (OS) is a complex procedure commonly used to treat dentofacial deformities (DFDs). These conditions, related to jaw position or size and often involving malocclusion, affect approximately 15% of the population.
Álvaro Pérez-Sala +14 more
doaj +1 more source
On the Structure of Equilibrium Strategies in Dynamic Gaussian Signaling Games
, 2016 This paper analyzes a finite horizon dynamic signaling game motivated by the well-known strategic information transmission problems in economics. The mathematical model involves information transmission between two agents, a sender who observes two ...
Akyol, Emrah +2 more
core +1 more source
Frontiers in PharmacologyIntroductionOpioid drugs are potent analgesics that mimic the endogenous opioid peptides, endorphins and enkephalins, by activating the µ-opioid receptor.
Sarah Warren Gooding +12 more
doaj +1 more source
Flagellar dynamics reveal fluctuations and kinetic limit in the Escherichia coli chemotaxis network
Scientific Reports, 2023 The Escherichia coli chemotaxis network, by which bacteria modulate their random run/tumble swimming pattern to navigate their environment, must cope with unavoidable number fluctuations (“noise”) in its molecular constituents like other signaling ...
Roshni Bano +3 more
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Pediatric sarcomas are a heterogeneous group of tumors that contribute disproportionately to cancer mortality in children. Although congenital anomalies are among the strongest known risk factors for childhood cancer, the risk of specific sarcoma subtypes among affected individuals has not yet been thoroughly evaluated. Procedure We
Russ Wolters +17 more
wiley +1 more source
Spatio-temporal regulation of concurrent developmental processes by generic signaling downstream of chemokine receptors [PDF]
, 2018 Chemokines are secreted proteins that regulate a range of processes in eukaryotic organisms. Interestingly, different chemokine receptors control distinct biological processes, and the same receptor can direct different cellular responses, but the basis ...
Malhotra, Divyanshu +3 more
core +2 more sources