Results 51 to 60 of about 6,937,440 (273)
Location bias contributes to functionally selective responses of biased CXCR3 agonists
Nature Communications, 2022 Subcellular signaling is critical to generating cellular responses that modulate inflammatory pathways at the chemokine receptor CXCR3. Eiger et al.
Dylan Scott Eiger +12 more
doaj +1 more source
BiasNet: A Model to Predict Ligand Bias Toward GPCR Signaling
Journal of Chemical Information and Modeling, 2021 Signaling bias is a feature of many G protein-coupled receptor (GPCR) targeting drugs with potential clinical implications. Whether it is therapeutically advantageous for a drug to be G protein biased or β-arrestin biased depends on the context of the ...
Jennifer Sánchez +4 more
semanticscholar +1 more source
Advances in Neural Information Processing Systems 37We introduce and study the problem of detecting whether an agent is updating their prior beliefs given new evidence in an optimal way that is Bayesian, or whether they are biased towards their own prior. In our model, biased agents form posterior beliefs that are a convex combination of their prior and the Bayesian posterior, where the more biased an ...
Yiling Chen 0001 +4 more
openaire +3 more sources
BIAS IN SELF‐EVALUATION: SIGNAL PROBABILITY EFFECTS [PDF]
Journal of the Experimental Analysis of Behavior, 1994 Two experiments examined apparent signal probability effects in simple verbal self‐reports. After each trial of a delayed matching‐to‐sample task, young adults pressed either a “yes” or a “no” button to answer a computer‐presented query about whether the most recent choice met a point contingency requiring both speed and accuracy. A successful matching‐
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Evaluation of Deviations Produced by Soft Tissue Fitting in Virtually Planned Orthognathic Surgery
Applied SciencesOrthognathic surgery (OS) is a complex procedure commonly used to treat dentofacial deformities (DFDs). These conditions, related to jaw position or size and often involving malocclusion, affect approximately 15% of the population.
Álvaro Pérez-Sala +14 more
doaj +1 more source
Kinetics of cytokine receptor trafficking determine signaling and functional selectivity
eLife, 2019 Cytokines activate signaling via assembly of cell surface receptors, but it is unclear whether modulation of cytokine-receptor binding parameters can modify biological outcomes.
Jonathan Martinez-Fabregas +12 more
doaj +1 more source
Sources of bias in signals of pharmaceutical safety in pregnancy
Clinical and Investigative Medicine, 2010 Every year scores of new pharmaceuticals enter the market, almost never with human fetal safety data. Such data typically accumulate during the first years of clinical use, in the form of case reports, case series, prospective and retrospective cohorts and case control studies. All of these methods suffer from serious sources of bias, often leading to
Gideon, Koren, Sheri, Nickel
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eLifeDeep Mutational Scanning (DMS) is an emerging method to systematically test the functional consequences of thousands of sequence changes to a protein target in a single experiment.
Conor J Howard +17 more
doaj +1 more source
GPCR signaling bias: an emerging framework for opioid drug development.
Journal of Biochemistry (Tokyo)Biased signaling has emerged as an important concept in drug development targeting G protein-coupled receptors (GPCRs). Drugs that provoke biased signaling are expected to offer an opportunity for enhanced therapeutic effectiveness with minimized side ...
Ryoji Kise, Asuka Inoue
semanticscholar +1 more source
G protein subtype–specific signaling bias in a series of CCR5 chemokine analogs
Science Signaling, 2018 Understanding how CCR5 signals through different G protein subtypes may lead to improved HIV drugs. Biasing CCR5 against inflammation The G protein–coupled chemokine receptor CCR5 is required for the cellular entry of HIV-1. The ideal drug targeting CCR5
Emily Lorenzen +6 more
semanticscholar +1 more source