Results 21 to 30 of about 442,339 (288)
G Protein and β-Arrestin Signaling Bias at the Ghrelin Receptor [PDF]
Journal of Biological Chemistry, 2014 Sean M Peterson +2 more
exaly +2 more sources
GPCR Binding and JNK3 Activation by Arrestin-3 Have Different Structural Requirements
Cells, 2023 Arrestins bind active phosphorylated G protein-coupled receptors (GPCRs). Among the four mammalian subtypes, only arrestin-3 facilitates the activation of JNK3 in cells.
Chen Zheng +5 more
doaj +1 more source
The Role of ICL1 and H8 in Class B1 GPCRs; Implications for Receptor Activation
Frontiers in Endocrinology, 2022 The first intracellular loop (ICL1) of G protein-coupled receptors (GPCRs) has received little attention, although there is evidence that, with the 8th helix (H8), it is involved in early conformational changes following receptor activation as well as ...
Ian Winfield +10 more
doaj +1 more source
Arrestins: Introducing Signaling Bias Into Multifunctional Proteins. [PDF]
Prog Mol Biol Transl Sci, 2018 Arrestins were discovered as proteins that bind active phosphorylated G protein-coupled receptors (GPCRs) and block their interactions with G proteins, i.e., for their role in homologous desensitization of GPCRs. Mammals express only four arrestin subtypes, two of which are largely restricted to the retina.
Gurevich VV, Chen Q, Gurevich EV.
europepmc +4 more sources
Differential Signaling Profiles of MC4R Mutations with Three Different Ligands [PDF]
, 2020 The melanocortin 4 receptor (MC4R) is a key player in hypothalamic weight regulation and energy expenditure as part of the leptin-melanocortin pathway. Mutations in this G protein coupled receptor (GPCR) are the most common cause for monogenetic obesity,
Annibale, Paolo +8 more
core +3 more sources
Nature Communications, 2023 Signaling bias is the ability of a receptor to differentially activate downstream signaling pathways in response to different ligands. Bias investigations have been hindered by inconsistent results in different cellular contexts.
Daniel Wirth +2 more
doaj +1 more source
Signal Evolution: ‘Shaky’ Evidence for Sensory Bias [PDF]
Current Biology, 2016 A study of tropical crickets suggests that a twitchy response to ultrasonic bat calls has been co-opted for mate location. The neuroethological approach picks apart some surprising evolutionary steps that could inform the widespread occurrence of complex duetting behaviour.
Pascoal, Sonia +2 more
openaire +2 more sources
Neural Signals for the Detection of Unintentional Race Bias [PDF]
Psychological Science, 2004 We examined the hypothesis that unintentional race-biased responses may occur despite the activation of neural systems that detect the need for control. Participants completed a sequential priming task that induced race-biased responses on certain trials while electroencephalography was recorded. The error-related negativity (ERN) wave, a component of
David M, Amodio +5 more
openaire +2 more sources
Computationally designed GPCR quaternary structures bias signaling pathway activation
Nature Communications, 2022 Computational modeling and design of G Protein-Coupled Receptor quaternary structures reveals a signaling bias switch at the receptor dimer interface that selectively controls G protein vs β-arrestin activation.
Justine S. Paradis +12 more
doaj +1 more source
Parmodulins Inhibit Thrombus Formation Without Inducing Endothelial Injury Caused by Vorapaxar [PDF]
, 2015 Protease-activated receptor-1 (PAR1) couples the coagulation cascade to platelet activation during myocardial infarction and to endothelial inflammation during sepsis. This receptor demonstrates marked signaling bias.
Ahn +52 more
core +2 more sources