CD40 ligand dictated signaling bias
BLDE University Journal of Health Sciences, 2020 T cells are pivotal for innate and adaptive immune response. On, T cell a co-stimulatory molecule CD40 ligand is present that binds to the CD40 receptor.
Akshata Ganesh Bammigatti
doaj +2 more sources
Overconfidence is a social signaling bias [PDF]
SSRN Electronic Journal, 2010 Evidence from psychology and economics indicates that many individuals overestimate their ability, both absolutely and relatively. We test three different theories about observed relative overconfidence.
Burks, Stephen V. +3 more
core +6 more sources
Evaluating signaling bias for synthetic cannabinoid receptor agonists at the cannabinoid CB2 receptor [PDF]
Pharmacol Res Perspect, 2023 The rapid structural evolution and emergence of novel synthetic cannabinoid receptor agonists (SCRAs) in the recreational market remains a key public health concern.
Patel M +4 more
europepmc +2 more sources
Signaling bias of the protease-activated receptor-1 is dictated by distinct GRK5 and β-arrestin-2 determinants. [PDF]
Cell RepSummary: G protein-coupled receptors (GPCRs) exhibit signaling bias or preferential activation of heterotrimeric G proteins versus GPCR kinase (GRK)-mediated β-arrestin signaling.
Gonzalez Ramirez ML +7 more
europepmc +2 more sources
Molecular basis of anaphylatoxin binding, activation, and signaling bias at complement receptors [PDF]
Cell, 2023 Manisankar Ganguly, Sudha Mishra
exaly +2 more sources
In Silico Study of Allosteric Communication Networks in GPCR Signaling Bias [PDF]
International Journal of Molecular Sciences, 2022 Francho Nerín-Fonz +2 more
exaly +2 more sources
Structural Insights into M1 Muscarinic Acetylcholine Receptor Signaling Bias between Gαq and β-Arrestin through BRET Assays and Molecular Docking [PDF]
International Journal of Molecular Sciences, 2023 Yifei Hou +2 more
exaly +2 more sources
Resonating with the signaling bias of CXCR7. [PDF]
Mol Cell, 2022 Kleist et al. combine NMR spectroscopy and residue contact network analysis to identify a potential allosteric network in CXCR7, a β-arrestin-biased chemokine receptor, which links the extracellular ligand-binding pocket and the intracellular transducer-coupling region through the receptor transmembrane core.
Sarma P, Shukla AK.
europepmc +3 more sources
Phylogenetic Signal and Bias in Paleontology [PDF]
Systematic Biology, 2021 AbstractAn unprecedented amount of evidence now illuminates the phylogeny of living mammals and birds on the Tree of Life. We use this tree to measure the phylogenetic value of data typically used in paleontology (bones and teeth) from six data sets derived from five published studies.
Asher, Robert, Smith, Martin
openaire +3 more sources
Human Gain-of-Function MC4R Variants Show Signaling Bias and Protect against Obesity [PDF]
Cell, 2019 Luca A Lotta +2 more
exaly +2 more sources