Results 41 to 50 of about 31,759 (252)

Prognostic value of β-Arrestins in combination with glucocorticoid receptor in epithelial ovarian cancer

Frontiers in Oncology, 2023
Hormones may be key factors driving cancer development, and epidemiological findings suggest that steroid hormones play a crucial role in ovarian tumorigenesis.
Ji-Won Ryu, Ha-Yeon Shin, Hyo-Sun Kim, Gwan Hee Han, Jeong Won Kim, Hae-Nam Lee, Hanbyoul Cho, Hanbyoul Cho, Hanbyoul Cho, Joon-Yong Chung, Jae-Hoon Kim, Jae-Hoon Kim, Jae-Hoon Kim   +12 more
doaj   +1 more source

GPCR Binding and JNK3 Activation by Arrestin-3 Have Different Structural Requirements

Cells, 2023
Arrestins bind active phosphorylated G protein-coupled receptors (GPCRs). Among the four mammalian subtypes, only arrestin-3 facilitates the activation of JNK3 in cells.
Chen Zheng, Liana D. Weinstein, Kevin K. Nguyen, Abhijeet Grewal, Eugenia V. Gurevich, Vsevolod V. Gurevich   +5 more
doaj   +1 more source

High Glucose Attenuates Cardioprotective Effects of Glucagon-Like Peptide-1 Through Induction of Mitochondria Dysfunction via Inhibition of β-Arrestin-Signaling

Frontiers in Physiology, 2021
An increased vulnerability has been detected after ischemia/reperfusion injury in cardiomyocytes in diabetic patients. Glucagon-like peptide-1 (GLP-1) has been proven to have a notable cardioprotective effect in cardiomyocytes.
Xietian Pan, Chengxiang Li, Haokao Gao
doaj   +1 more source

Ascidian arrestin (Ci‐arr), the origin of the visual and nonvisual arrestins of vertebrate [PDF]

European Journal of Biochemistry, 2002
Arrestin is one of the key proteins for the termination of G protein signaling. Activated G protein‐coupled receptors (GPCRs) are specifically phosphorylated by G protein‐coupled receptor kinases (GRKs) and then bind to arrestins to preclude the receptor/G protein interaction, resulting in quenching of the following signal transduction.
Masashi, Nakagawa, Hidefumi, Orii, Norihiro, Yoshida, Eri, Jojima, Takeo, Horie, Reiko, Yoshida, Tatsuya, Haga, Motoyuki, Tsuda   +7 more
openaire   +2 more sources

β-Arrestin-linked fluctuating network of β₂AR.

, 2016
(A) Fluctuating atomsβ-arrestin, which have a Pearson’s correlation coefficient of more than 0.6 between their ΔRMSF and β-arrestin efficacy, are indicated by blue spheres.
Osamu Ichikawa (3169788), Kazuto Yamazaki (9494), Atsushi Yamada (282892), Kazushi Fujimoto (1730860), Susumu Okazaki (3169791)   +4 more
core   +1 more source

Distinct membrane binding properties of the two non-visual arrestins

Communications Biology
Membrane interactions play a crucial role in regulating arrestin activation and its binding to phosphorylated G protein-coupled receptors (GPCRs).
Thomas D. Killeen, Katelyn Tepper, Kyle W. Miller, Yasmin Aydin, Ya Zhuo, Shuaitong Zhao, Jason M. Conley, Rachel Tat, Candice S. Klug, Adriano Marchese, Valerică Raicu, Qiuyan Chen   +11 more
doaj   +1 more source

G Protein-Coupled Receptor Kinase 2 Selectively Enhances β-Arrestin Recruitment to the D₂ Dopamine Receptor through Mechanisms That Are Independent of Receptor Phosphorylation

Biomolecules, 2023
The D2 dopamine receptor (D2R) signals through both G proteins and β-arrestins to regulate important physiological processes, such as movement, reward circuitry, emotion, and cognition.
Marta Sánchez-Soto, Noelia M. Boldizsar, Kayla A. Schardien, Nora S. Madaras, Blair K. A. Willette, Laura R. Inbody, Christopher Dasaro, Amy E. Moritz, Julia Drube, Raphael S. Haider, R. Benjamin Free, Carsten Hoffman, David R. Sibley   +12 more
doaj   +1 more source

Structure and functions of arrestins [PDF]

Protein Science, 1994
AbstractTransmembrane signal transductions in a variety of cell types that mediate signals as diverse as those carried by neurotransmitters, hormones, and sensory signals share basic biochemical mechanisms that include: (1) an extracellular perturbation (neurotransmitter, hormone, odor, light); (2) specific receptors; (3) coupling proteins, such as G ...
openaire   +2 more sources

Single‐Cell Transcriptomics and Metabolomics Reveal Glutamate Dehydrogenase as a Central Regulator of Nitrogen Metabolic Remodeling During Alkalinity Adaptation in Crustaceans

Advanced Science, EarlyView.
Single‐cell transcriptomics reveals the cellular response of Macrobrachium hainanense to carbonate alkalinity stress. Alkalinity stress impairs branchial ammonia excretion, induces mitochondrial dysfunction, and drives cell‐type‐specific changes in gills and hemocytes.
Yiting Jin, Zhimin Lv, Chao Bian, Qibin Yang, Na Zhou, Jianguang Qin, Shengming Sun   +6 more
wiley   +1 more source

Targeting β2‐Adrenergic Receptor Stability With Lycorine Reveals a Host‐Directed Pathway for Antiviral Defense Against Poxviruses

Advanced Science, EarlyView.
Chronic stress drives autophagy‐mediated β2‐AR degradation, impairing antiviral immunity and promoting poxvirus lethality. Lycorine directly stabilizes β2‐AR to restore host defense, suppress excessive inflammation and improve survival. ABSTRACT Psychological stress is a pervasive yet poorly understood modulator of infectious disease outcomes. Here, we
Xin Zhang, Shuqin Xu, Zixuan Zhang, Chenwen Wan, Xiaoqin Wang, Peihua Wang, Huini Yang, Tianxiao Huang, Yijia Yuan, Faiza Atique, Rui Yang, Yingli He, Zhijun Liu   +12 more
wiley   +1 more source