Results 21 to 30 of about 24,311 (208)

β-arrestin 2 Is a Prognostic Factor for Survival of Ovarian Cancer Patients Upregulating Cell Proliferation

Frontiers in Endocrinology, 2020
Establishing reliable prognostic factors as well as specific targets for new therapeutic approaches is an urgent requirement in advanced ovarian cancer. For several tumor entities, the ubiquitously spread scaffold protein β-arrestin 2, a multifunctional ...
Bastian Czogalla, Alexandra Partenheimer, Udo Jeschke, Udo Jeschke, Viktoria von Schönfeldt, Doris Mayr, Sven Mahner, Alexander Burges, Manuela Simoni, Manuela Simoni, Manuela Simoni, Manuela Simoni, Beatrice Melli, Riccardo Benevelli, Sara Bertini, Livio Casarini, Livio Casarini, Fabian Trillsch   +17 more
doaj   +1 more source

β-Arrestin-dependent deactivation of mouse melanopsin.

PLoS ONE, 2014
In mammals, the expression of the unusual visual pigment, melanopsin, is restricted to a small subset of intrinsically photosensitive retinal ganglion cells (ipRGCs), whose signaling regulate numerous non-visual functions including sleep, circadian ...
Evan G Cameron, Phyllis R Robinson
doaj   +1 more source

Cannabinoid CB1 and CB2 Receptor-Mediated Arrestin Translocation: Species, Subtype, and Agonist-Dependence

Frontiers in Pharmacology, 2019
Arrestin translocation and signaling have come to the fore of the G protein-coupled receptor molecular pharmacology field. Some receptor–arrestin interactions are relatively well understood and considered responsible for specific therapeutic or adverse ...
Mikkel Søes Ibsen, Mikkel Søes Ibsen, David B. Finlay, Monica Patel, Monica Patel, Jonathan A. Javitch, Jonathan A. Javitch, Michelle Glass, Natasha Lillia Grimsey, Natasha Lillia Grimsey   +9 more
doaj   +1 more source

The Effects of Apelin and Elabela Ligands on Apelin Receptor Distinct Signaling Profiles

Frontiers in Pharmacology, 2021
Apelin and Elabela are endogenous peptide ligands for Apelin receptor (APJ), a widely expressed G protein-coupled receptor. They constitute a spatiotemporal dual ligand system to control APJ signal transduction and function.
Yunlu Jiang, Maocai Yan, Chunmei Wang, Qinqin Wang, Xiaoyu Chen, Rumin Zhang, Lei Wan, Bingyuan Ji, Bo Dong, Huiyun Wang, Jing Chen, Jing Chen   +11 more
doaj   +1 more source

Functional characterization of an arrestin gene on insecticide resistance of Culex pipiens pallens

Parasites & Vectors, 2012
Background Continuous and excessive application of insecticides has resulted in the rapid development of insecticide resistance in several mosquito species, including Culex pipiens pallens.
Sun Yan, Zou Ping, Yu Xin-You, Chen Chen, Yu Jing, Shi Lin-Na, Hong Shan-Chao, Zhou Dan, Chang Xue-Lian, Wang Wei-Jie, Shen Bo, Zhang Dong-Hui, Ma Lei, Zhu Chang-Liang   +13 more
doaj   +1 more source

Evolution of the shut-off steps of vertebrate phototransduction [PDF]

Open Biology, 2018
Different isoforms of the genes involved in phototransduction are expressed in vertebrate rod and cone photoreceptors, providing a unique example of parallel evolution via gene duplication.
Trevor D. Lamb, Hardip R. Patel, Aaron Chuah, David M. Hunt   +3 more
doaj   +1 more source

The Dynamics of the Neuropeptide Y Receptor Type 1 Investigated by Solid-State NMR and Molecular Dynamics Simulation

Molecules, 2020
We report data on the structural dynamics of the neuropeptide Y (NPY) G-protein-coupled receptor (GPCR) type 1 (Y1R), a typical representative of class A peptide ligand GPCRs, using a combination of solid-state NMR and molecular dynamics (MD) simulation.
Alexander Vogel, Mathias Bosse, Marcel Gauglitz, Sarah Wistuba, Peter Schmidt, Anette Kaiser, Vsevolod V. Gurevich, Annette G. Beck-Sickinger, Peter W. Hildebrand, Daniel Huster   +9 more
doaj   +1 more source

Diversity of Light Sensing Molecules and Their Expression During the Embryogenesis of the Cuttlefish (Sepia officinalis)

Frontiers in Physiology, 2020
Eyes morphologies may differ but those differences are not reflected at the molecular level. Indeed, the ability to perceive light is thought to come from the same conserved gene families: opsins and cryptochromes.
Morgane Bonadè, Atsushi Ogura, Erwan Corre, Yann Bassaglia, Yann Bassaglia, Laure Bonnaud-Ponticelli   +5 more
doaj   +1 more source

G Protein-Coupled Receptor Kinase 2 Selectively Enhances β-Arrestin Recruitment to the D₂ Dopamine Receptor through Mechanisms That Are Independent of Receptor Phosphorylation

Biomolecules, 2023
The D2 dopamine receptor (D2R) signals through both G proteins and β-arrestins to regulate important physiological processes, such as movement, reward circuitry, emotion, and cognition.
Marta Sánchez-Soto, Noelia M. Boldizsar, Kayla A. Schardien, Nora S. Madaras, Blair K. A. Willette, Laura R. Inbody, Christopher Dasaro, Amy E. Moritz, Julia Drube, Raphael S. Haider, R. Benjamin Free, Carsten Hoffman, David R. Sibley   +12 more
doaj   +1 more source

The Effect of Cell Surface Expression and Linker Sequence on the Recruitment of Arrestin to the GIP Receptor

Frontiers in Pharmacology, 2020
The glucose-dependent insulinotropic polypeptide (GIP) and the glucagon-like peptide-1 (GLP-1) receptor are important targets in the treatment of both type 2 diabetes mellitus (T2DM) and obesity.
Suleiman Al-Sabah, Lobna Adi, Moritz Bünemann, Cornelius Krasel   +3 more
doaj   +1 more source