Results 21 to 30 of about 24,588 (216)

Evolution of the shut-off steps of vertebrate phototransduction [PDF]

Open Biology, 2018
Different isoforms of the genes involved in phototransduction are expressed in vertebrate rod and cone photoreceptors, providing a unique example of parallel evolution via gene duplication.
Trevor D. Lamb, Hardip R. Patel, Aaron Chuah, David M. Hunt   +3 more
doaj   +1 more source

β-Arrestin-dependent deactivation of mouse melanopsin.

PLoS ONE, 2014
In mammals, the expression of the unusual visual pigment, melanopsin, is restricted to a small subset of intrinsically photosensitive retinal ganglion cells (ipRGCs), whose signaling regulate numerous non-visual functions including sleep, circadian ...
Evan G Cameron, Phyllis R Robinson
doaj   +1 more source

Cannabinoid CB1 and CB2 Receptor-Mediated Arrestin Translocation: Species, Subtype, and Agonist-Dependence

Frontiers in Pharmacology, 2019
Arrestin translocation and signaling have come to the fore of the G protein-coupled receptor molecular pharmacology field. Some receptor–arrestin interactions are relatively well understood and considered responsible for specific therapeutic or adverse ...
Mikkel Søes Ibsen, Mikkel Søes Ibsen, David B. Finlay, Monica Patel, Monica Patel, Jonathan A. Javitch, Jonathan A. Javitch, Michelle Glass, Natasha Lillia Grimsey, Natasha Lillia Grimsey   +9 more
doaj   +1 more source

DEER Analysis of GPCR Conformational Heterogeneity

Biomolecules, 2021
G protein-coupled receptors (GPCRs) represent a large class of transmembrane helical proteins which are involved in numerous physiological signaling pathways and therefore represent crucial pharmacological targets.
Matthias Elgeti, Wayne L. Hubbell
doaj   +1 more source

Functional characterization of an arrestin gene on insecticide resistance of Culex pipiens pallens

Parasites & Vectors, 2012
Background Continuous and excessive application of insecticides has resulted in the rapid development of insecticide resistance in several mosquito species, including Culex pipiens pallens.
Sun Yan, Zou Ping, Yu Xin-You, Chen Chen, Yu Jing, Shi Lin-Na, Hong Shan-Chao, Zhou Dan, Chang Xue-Lian, Wang Wei-Jie, Shen Bo, Zhang Dong-Hui, Ma Lei, Zhu Chang-Liang   +13 more
doaj   +1 more source

Arrestin-Coding Genes Regulate Endocytosis, Sporulation, Pathogenicity, and Stress Resistance in Arthrobotrys oligospora

Frontiers in Cellular and Infection Microbiology, 2022
Arrestins are a family of scaffold proteins that play a crucial role in regulating numerous cellular processes, such as GPCR signaling. The Arthrobotrys oligospora arrestin family contains 12 members, which have highly conserved N-terminal and C-terminal
Liang Zhou, Liang Zhou, Mengfei Li, Mengfei Li, Peijie Cui, Peijie Cui, Mengqing Tian, Mengqing Tian, Ya Xu, Ya Xu, Xi Zheng, Xi Zheng, Keqin Zhang, Keqin Zhang, Guohong Li, Guohong Li, Xin Wang, Xin Wang   +17 more
doaj   +1 more source

Isoflurane induces Art2‐Rsp5‐dependent endocytosis of Bap2 in yeast

FEBS Open Bio, 2021
Although general anesthesia is indispensable during modern surgical procedures, the mechanism by which inhalation anesthetics act on the synaptic membrane at the molecular and cellular level is largely unknown.
Fumi Kozu, Kanae Shirahama‐Noda, Yasuhiro Araki, Shintaro Kira, Hitoshi Niwa, Takeshi Noda   +5 more
doaj   +1 more source

GPCR Binding and JNK3 Activation by Arrestin-3 Have Different Structural Requirements

Cells, 2023
Arrestins bind active phosphorylated G protein-coupled receptors (GPCRs). Among the four mammalian subtypes, only arrestin-3 facilitates the activation of JNK3 in cells.
Chen Zheng, Liana D. Weinstein, Kevin K. Nguyen, Abhijeet Grewal, Eugenia V. Gurevich, Vsevolod V. Gurevich   +5 more
doaj   +1 more source

High Glucose Attenuates Cardioprotective Effects of Glucagon-Like Peptide-1 Through Induction of Mitochondria Dysfunction via Inhibition of β-Arrestin-Signaling

Frontiers in Physiology, 2021
An increased vulnerability has been detected after ischemia/reperfusion injury in cardiomyocytes in diabetic patients. Glucagon-like peptide-1 (GLP-1) has been proven to have a notable cardioprotective effect in cardiomyocytes.
Xietian Pan, Chengxiang Li, Haokao Gao
doaj   +1 more source

On the origins of arrestin and rhodopsin [PDF]

BMC Evolutionary Biology, 2008
G protein coupled receptors (GPCRs) are the most numerous proteins in mammalian genomes, and the most common targets of clinical drugs. However, their evolution remains enigmatic. GPCRs are intimately associated with trimeric G proteins, G protein receptor kinases, and arrestins. We conducted phylogenetic studies to reconstruct the history of arrestins.
openaire   +3 more sources