Results 21 to 30 of about 31,759 (252)
Image_1_B-arrestin-2 Signaling Is Important to Preserve Cardiac Function During Aging.pdf
, 2021 Experiments reported here tested the hypothesis that β-arrestin-2 is an important element in the preservation of cardiac function during aging. We tested this hypothesis by aging β-arrestin-2 knock-out (KO) mice, and wild-type equivalent (WT) to 12 ...
Andrielle E. Capote (11341026) +6 more
core +1 more source
The effect of arrestin conformation on the recruitment of c-Raf1, MEK1, and ERK1/2 activation.
PLoS ONE, 2011 Arrestins are multifunctional signaling adaptors originally discovered as proteins that "arrest" G protein activation by G protein-coupled receptors (GPCRs).
Sergio Coffa +6 more
doaj +1 more source
, 2015 Arrestins specifically bind active phosphorylated G protein-coupled receptors (GPCRs). Receptor binding induces the release of the arrestin C-tail, which in non-visual arrestins contains high-affinity binding sites for clathrin and its adaptor AP2. Thus, serving as a physical link between the receptor and key components of the internalization machinery
Vsevolod V, Gurevich +1 more
openaire +2 more sources
The β-blocker Nebivolol Is a GRK/β-arrestin Biased Agonist [PDF]
, 2013 Nebivolol, a third generation β-adrenoceptor (β-AR) antagonist (β-blocker), causes vasodilation by inducing nitric oxide (NO) production. The mechanism via which nebivolol induces NO production remains unknown, resulting in the genesis of much of the ...
Jackson, Edwin K. +36 more
core +2 more sources
β-Arrestin-Mediated Signaling Improves the Efficacy of Therapeutics
Journal of Pharmacological Sciences, 2012 β-Arrestins (β-arrestin-1 and β-arrestin-2) were first identified as proteins that have the ability to desensitize G protein-coupled receptors (GPCRs). However, it has recently been found that β-arrestins can activate signaling pathways independent of G ...
Islam A.A.E.-H. Ibrahim, Hitoshi Kurose
doaj +1 more source
Letter to the Editor: LO2, a misidentified cell line: Some data should be interpreted with caution
, 2022 Hepatology, EarlyView.
Ralf Weiskirchen
wiley +1 more source
Effect of ibuprofen intervention on NLRP3, GPR120 and β-Arrestin-2 protein expression.
, 2023 (a1) Protein expression levels of NLRP3. (a2) Western Blot of NLRP3 expression. (b1) Protein expression levels of GPR120. (b2) Western Blot of GPR120 expression. (c1) Protein expression of β-Arrestin-2. (c2) Western Blot of β-Arrestin-2 expression.
Yifan Feng (132121) +4 more
core +1 more source
Evolution of the shut-off steps of vertebrate phototransduction [PDF]
Open Biology, 2018 Different isoforms of the genes involved in phototransduction are expressed in vertebrate rod and cone photoreceptors, providing a unique example of parallel evolution via gene duplication.
Trevor D. Lamb +3 more
doaj +1 more source
Frontiers in Endocrinology, 2020 Establishing reliable prognostic factors as well as specific targets for new therapeutic approaches is an urgent requirement in advanced ovarian cancer. For several tumor entities, the ubiquitously spread scaffold protein β-arrestin 2, a multifunctional ...
Bastian Czogalla +17 more
doaj +1 more source
β-arrestin–based biosensors: Tools to explore structural determinants of metabolic functions?
, 2021 The arrestin family of proteins is known to regulate receptor desensitization and trafficking of cell surface receptors, especially G protein–coupled receptors.
Hoffmann, Carsten +2 more
core +1 more source