Results 1 to 10 of about 9,354 (195)

The Atypical Chemerin Receptor GPR1 Displays Different Modes of Interaction with β-Arrestins in Humans and Mice with Important Consequences on Subcellular Localization and Trafficking

Cells, 2022
Atypical chemokine receptors (ACKRs) have emerged as a subfamily of chemokine receptors regulating the local bioavailability of their ligands through scavenging, concentration, or transport.
Marc Parmentier, Jean-Yves Springael, Valentin LEPAGE   +2 more
exaly   +3 more sources

β-arrestin recruitment facilitates a direct association with G proteins [PDF]

Nature Communications
G protein-coupled receptors (GPCRs) are targets for almost a third of all FDA-approved drugs. GPCRs are known to signal through both heterotrimeric G proteins and β-arrestins. Traditionally these pathways were viewed as largely separable, with G proteins
Claudia Y. Lee, Jeffrey S. Smith, Taylor Kohlmann, Emily M. Meara, Uyen Pham, Frank Kwarcinski, Andrew N. Dates, Jessica K. Orofino, Issac Choi, Ari S. Hilibrand, Chanpreet Jassal, Abigail Gilmer, Stephen C. Blacklow, Gregory G. Tall, Andrew C. Kruse, Sudarshan Rajagopal   +15 more
doaj   +2 more sources

ACKR4 Recruits GRK3 Prior to β-Arrestins but Can Scavenge Chemokines in the Absence of β-Arrestins

Frontiers in Immunology, 2020
Chemokines are essential for guiding cell migration. Atypical chemokine receptors (ACKRs) contribute to the cell migration process by binding, internalizing and degrading local chemokines, which enables the formation of confined gradients.
Christoph Matti, Angela Salnikov, Marc Artinger, Gianluca D'Agostino, Ilona Kindinger, Mariagrazia Uguccioni, Marcus Thelen, Daniel F. Legler, Daniel F. Legler, Daniel F. Legler   +9 more
doaj   +2 more sources

RNAi targeting Caenorhabditis elegans α-arrestins has little effect on lifespan [version 4; referees: 2 approved, 1 approved with reservations]

F1000Research, 2017
Background: α-arrestins are a family of proteins that are implicated in multiple biological processes, including metabolism and receptor desensitization.
Sangsoon Park, Yoonji Jung, Seon Woo A. An, Heehwa G. Son, Wooseon Hwang, Dongyeop Lee, Murat Artan, Hae-Eun H. Park, Dae-Eun Jeong, Yujin Lee, Seung-Jae V. Lee   +10 more
doaj   +3 more sources

Historical Perspective of the G Protein-Coupled Receptor Kinase Family

Cells, 2021
Agonist activation of G protein-coupled receptors promotes sequential interaction of the receptor with heterotrimeric G proteins, G protein-coupled receptor kinases (GRKs), and arrestins. GRKs play a central role in mediating the switch from G protein to
Jeffrey L. Benovic
doaj   +1 more source

Interactions between β-arrestin proteins and the cytoskeletal system, and their relevance to neurodegenerative disorders

Frontiers in Endocrinology, 2023
β-arrestins, which have multiple cellular functions, were initially described as proteins that desensitize rhodopsin and other G protein-coupled receptors.
Tibor Szénási, Gábor Turu, Gábor Turu, László Hunyady, László Hunyady   +4 more
doaj   +1 more source

TORC1 Signaling Controls the Stability and Function of α-Arrestins Aly1 and Aly2

Biomolecules, 2022
Nutrient supply dictates cell signaling changes, which in turn regulate membrane protein trafficking. To better exploit nutrients, cells relocalize membrane transporters via selective protein trafficking.
Ray W. Bowman, Eric M. Jordahl, Sydnie Davis, Stefanie Hedayati, Hannah Barsouk, Nejla Ozbaki-Yagan, Annette Chiang, Yang Li, Allyson F. O’Donnell   +8 more
doaj   +1 more source

RNAi targeting Caenorhabditis elegans α-arrestins has small or no effects on lifespan [version 2; referees: 2 approved, 1 approved with reservations]

F1000Research, 2017
Background: α-arrestins are a family of proteins that are implicated in multiple biological processes, including metabolism and receptor desensitization.
Sangsoon Park, Yoonji Jung, Seon Woo A. An, Heehwa G. Son, Wooseon Hwang, Dongyeop Lee, Murat Artan, Hae-Eun H. Park, Dae-Eun Jeong, Yujin Lee, Seung-Jae V. Lee   +10 more
doaj   +1 more source

Endothelial β‐arrestins regulate mechanotransduction by the type II bone morphogenetic protein receptor in primary cilia

Pulmonary Circulation, 2022
Modulation of endothelial cell behavior and phenotype by hemodynamic forces involves many signaling components, including cell surface receptors, intracellular signaling intermediaries, transcription factors, and epigenetic elements.
Saejeong Park, Zhiyuan Ma, Georgia Zarkada, Irinna Papangeli, Sarin Paluri, Nour Nazo, Felix Rivera‐Molina, Derek Toomre, Sudarshan Rajagopal, Hyung J. Chun   +9 more
doaj   +1 more source

Therapeutic Potential of Targeting ß-Arrestin

Frontiers in Pharmacology, 2019
ß-arrestins are multifunctional proteins that modulate heptahelical 7 transmembrane receptors, also known as G protein-coupled receptors (GPCRs), a superfamily of receptors that regulate most physiological processes.
Richard A. Bond, Emilio Y. Lucero Garcia-Rojas, Akhil Hegde, Julia K. L. Walker   +3 more
doaj   +1 more source