Results 1 to 10 of about 7,477 (214)
On the origins of arrestin and rhodopsin [PDF]
BMC Evolutionary Biology, 2008 Background G protein coupled receptors (GPCRs) are the most numerous proteins in mammalian genomes, and the most common targets of clinical drugs. However, their evolution remains enigmatic.
Alvarez Carlos E
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Cells, 2022 Atypical chemokine receptors (ACKRs) have emerged as a subfamily of chemokine receptors regulating the local bioavailability of their ligands through scavenging, concentration, or transport.
Marc Parmentier +2 more
exaly +3 more sources
GRKs and β-Arrestins: “Gatekeepers” of Mitochondrial Function in the Failing Heart
Frontiers in Pharmacology, 2019 Mitochondrial regulation of energy production, calcium homeostasis, and cell death are critical for cardiac function. Accordingly, the structural and functional abnormalities of these organelles (mitochondrial dysfunction) contribute to developing ...
Jessica Gambardella +2 more
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Arrestin development: a role for β-arrestins in viral myocarditis. [PDF]
Am J Physiol Heart Circ PhysiolDasgupta S +2 more
europepmc +3 more sources
Light intensity-dependent arrestin switching for inactivation of a light-sensitive GPCR, bistable opsin [PDF]
iScienceSummary: Inactivation of most light-sensitive G protein-coupled receptor (GPCR) opsins involves arrestin binding to terminate cell responses. In the zebrafish pineal organ, UV sensitive parapinopsin 1 (PP1)-expressing cells exhibit color opponency ...
Baoguo Shen +8 more
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Historical Perspective of the G Protein-Coupled Receptor Kinase Family
Cells, 2021 Agonist activation of G protein-coupled receptors promotes sequential interaction of the receptor with heterotrimeric G proteins, G protein-coupled receptor kinases (GRKs), and arrestins. GRKs play a central role in mediating the switch from G protein to
Jeffrey L. Benovic
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The arrestin superfamily: cone arrestins are a fourth family [PDF]
FEBS Letters, 1995 Arrestins constitute a superfamily of regulatory proteins that down‐regulate phosphorylated G‐protein membrane receptors, including rod and cone photoreceptors and adrenergic receptors. The potential role of arrestin in color visual processes led us to identify a cDNA encoding a cone‐like arrestin in Xenopus laevis, the principle amphibian biological ...
Craft, Cheryl M., Whitmore, Donald H.
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Cardiomyocyte β-arrestins mediate inflammation and cGAS-STING activation in CVB3 viral myocarditis [PDF]
American Journal of Physiology - Heart and Circulatory PhysiologyLucero EY +10 more
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Frontiers in Endocrinology, 2023 β-arrestins, which have multiple cellular functions, were initially described as proteins that desensitize rhodopsin and other G protein-coupled receptors.
Tibor Szénási +4 more
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, 2013 Programmed cell death (apoptosis) is a coordinated set of events eventually leading to the massive activation of specialized proteases (caspases) that cleave numerous substrates, orchestrating fairly uniform biochemical changes than culminate in cellular suicide. Apoptosis can be triggered by a variety of stimuli, from external signals or growth factor
Seunghyi, Kook +2 more
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