Results 41 to 50 of about 9,354 (195)

β-Arrestin regulation of myosin light chain phosphorylation promotes AT1aR-mediated cell contraction and migration. [PDF]

PLoS ONE, 2013
Over the last decade, it has been established that G-protein-coupled receptors (GPCRs) signal not only through canonical G-protein-mediated mechanisms, but also through the ubiquitous cellular scaffolds β-arrestin-1 and β-arrestin-2.
Elie Simard, Jeffrey J Kovacs, William E Miller, Jihee Kim, Michel Grandbois, Robert J Lefkowitz   +5 more
doaj   +1 more source

Accelerated evolution of dim-light vision-related arrestin in deep-diving amniotes

Frontiers in Ecology and Evolution, 2022
Arrestins are key molecules involved in the signaling of light-sensation initiated by visual pigments in retinal photoreceptor cells. Vertebrate photoreceptor cells have two types of arrestins, rod arrestin, which is encoded by SAG and is expressed in ...
Xin Guo, Yimeng Cui, David M. Irwin, Yang Liu   +3 more
doaj   +1 more source

Structure and functions of arrestins [PDF]

Protein Science, 1994
AbstractTransmembrane signal transductions in a variety of cell types that mediate signals as diverse as those carried by neurotransmitters, hormones, and sensory signals share basic biochemical mechanisms that include: (1) an extracellular perturbation (neurotransmitter, hormone, odor, light); (2) specific receptors; (3) coupling proteins, such as G ...
openaire   +2 more sources

Lack of beta-arrestin signaling in the absence of active G proteins

Nature Communications, 2018
Arrestins terminate signaling from GPCRs, but several lines of evidence suggest that they are also able to transduce signals independently of G proteins. Here, the authors systematically ablate G proteins in cell lines, and show that arrestins are unable
Manuel Grundmann, Nicole Merten, Davide Malfacini, Asuka Inoue, Philip Preis, Katharina Simon, Nelly Rüttiger, Nicole Ziegler, Tobias Benkel, Nina Katharina Schmitt, Satoru Ishida, Ines Müller, Raphael Reher, Kouki Kawakami, Ayumi Inoue, Ulrike Rick, Toni Kühl, Diana Imhof, Junken Aoki, Gabriele M. König, Carsten Hoffmann, Jesus Gomeza, Jürgen Wess, Evi Kostenis   +23 more
doaj   +1 more source

Discrete GPCR-triggered endocytic modes enable β-arrestins to flexibly regulate cell signaling

eLife, 2022
β-Arrestins are master regulators of cellular signaling that operate by desensitizing ligand-activated G-protein-coupled receptors (GPCRs) at the plasma membrane and promoting their subsequent endocytosis.
Benjamin Barsi-Rhyne, Aashish Manglik, Mark von Zastrow   +2 more
doaj   +1 more source

The effect of arrestin conformation on the recruitment of c-Raf1, MEK1, and ERK1/2 activation.

PLoS ONE, 2011
Arrestins are multifunctional signaling adaptors originally discovered as proteins that "arrest" G protein activation by G protein-coupled receptors (GPCRs).
Sergio Coffa, Maya Breitman, Susan M Hanson, Kari Callaway, Seunghyi Kook, Kevin N Dalby, Vsevolod V Gurevich   +6 more
doaj   +1 more source

Arrestins expressed in killifish photoreceptor cells [PDF]

, 1997
Two kinds of cDNA fragments (KfhArr-R and KfhArr-C) encoding the putative arrestins of killifish, Oryzias latipes, were isolated. The distributions of these transcripts were investigated by in situ hybridization, and it was demonstrated that KfhArr-R and
Satoh, Takunori, Fumio Tokunaga, Tokunaga, Fumio, Imanishi, Yoshikazu, Takunori Satoh, Hisatomi, Osamu, Osamu Hisatomi, Yoshikazu Imanishi   +7 more
core   +1 more source

α-Arrestins and Their Functions: From Yeast to Human Health

, 2022
α-Arrestins, also called arrestin-related trafficking adaptors (ARTs), constitute a large family of proteins conserved from yeast to humans. Despite their evolutionary precedence over their extensively studied relatives of the β-arrestin family, α ...
Zbieralski, Kacper, Donata Wawrzycka, Wawrzycka, Donata, Kacper Zbieralski   +3 more
core   +1 more source

GRKs and β-Arrestins: “Gatekeepers” of Mitochondrial Function in the Failing Heart

Frontiers in Pharmacology, 2019
Mitochondrial regulation of energy production, calcium homeostasis, and cell death are critical for cardiac function. Accordingly, the structural and functional abnormalities of these organelles (mitochondrial dysfunction) contribute to developing ...
Daniela Sorriento, Jessica Gambardella, Antonella Fiordelisi, Guido Iaccarino, Maddalena Illario   +4 more
doaj   +1 more source

A lipidated peptide derived from the C-terminal tail of the vasopressin 2 receptor shows promise as a new β-arrestin inhibitor

Pharmacological Research
β-arrestins play pivotal roles in seven transmembrane receptor (7TMR) signalling and trafficking. To study their functional role in regulating specific receptor systems, current research relies mainly on genetic tools, as few pharmacological options are ...
Rebecca L. Brouillette, Christine E. Mona, Michael Desgagné, Malihe Hassanzedeh, Émile Breault, Frédérique Lussier, Karine Belleville, Jean-Michel Longpré, Michel Grandbois, Pierre-Luc Boudreault, Élie Besserer-Offroy, Philippe Sarret   +11 more
doaj   +1 more source