The Atypical Chemerin Receptor GPR1 Displays Different Modes of Interaction with β-Arrestins in Humans and Mice with Important Consequences on Subcellular Localization and Trafficking [PDF]
Cells, 2022 Atypical chemokine receptors (ACKRs) have emerged as a subfamily of chemokine receptors regulating the local bioavailability of their ligands through scavenging, concentration, or transport.
Valentin Lepage +2 more
exaly +4 more sources
Endothelial β‐arrestins regulate mechanotransduction by the type II bone morphogenetic protein receptor in primary cilia [PDF]
Pulmonary Circulation, 2022 Modulation of endothelial cell behavior and phenotype by hemodynamic forces involves many signaling components, including cell surface receptors, intracellular signaling intermediaries, transcription factors, and epigenetic elements.
Saejeong Park +9 more
doaj +2 more sources
ACKR4 Recruits GRK3 Prior to β-Arrestins but Can Scavenge Chemokines in the Absence of β-Arrestins [PDF]
Frontiers in Immunology, 2020 Chemokines are essential for guiding cell migration. Atypical chemokine receptors (ACKRs) contribute to the cell migration process by binding, internalizing and degrading local chemokines, which enables the formation of confined gradients.
Christoph Matti +9 more
doaj +2 more sources
Discrete GPCR-triggered endocytic modes enable β-arrestins to flexibly regulate cell signaling [PDF]
eLife, 2022 β-Arrestins are master regulators of cellular signaling that operate by desensitizing ligand-activated G-protein-coupled receptors (GPCRs) at the plasma membrane and promoting their subsequent endocytosis.
Benjamin Barsi-Rhyne +2 more
doaj +2 more sources
The multifaceted functions of β-arrestins and their therapeutic potential in neurodegenerative diseases [PDF]
Experimental and Molecular MedicineArrestins are multifunctional proteins that regulate G-protein-coupled receptor (GPCR) desensitization, signaling, and internalization. The arrestin family consists of four subtypes: visual arrestin1, β-arrestin1, β-arrestin2, and visual arrestin-4 ...
Teresa R. Kee +7 more
doaj +2 more sources
Carvedilol targets β-arrestins to rewire innate immunity and improve oncolytic adenoviral therapy [PDF]
Communications Biology, 2022 Hoare et al describe a drug-repurposing approach and report that carvedilol, a β-arrestin-biased β-blocker, exhibits synergistic anti-ovarian cancer effects with oncolytic adenovirus.
Joseph I. Hoare +9 more
doaj +2 more sources
GRKs and β-Arrestins: “Gatekeepers” of Mitochondrial Function in the Failing Heart [PDF]
Frontiers in Pharmacology, 2019 Mitochondrial regulation of energy production, calcium homeostasis, and cell death are critical for cardiac function. Accordingly, the structural and functional abnormalities of these organelles (mitochondrial dysfunction) contribute to developing ...
Daniela Sorriento +4 more
doaj +2 more sources
Regulation of cardiac fibroblast-mediated maladaptive ventricular remodeling by β-arrestins. [PDF]
PLoS ONE, 2019 Cardiac fibroblasts (CF) play a critical role in post-infarction remodeling which can ultimately lead to pathological fibrosis and heart failure.
Jennifer L Philip +4 more
doaj +2 more sources
Therapeutic Targets for Treatment of Heart Failure: Focus on GRKs and β-Arrestins Affecting βAR Signaling [PDF]
Frontiers in Pharmacology, 2018 Heart failure (HF) is a heart disease that is classified into two main types: HF with reduced ejection fraction (HFrEF) and HF with preserved ejection fraction (HFpEF). Both types of HF lead to significant risk of mortality and morbidity. Pharmacological
Supachoke Mangmool +2 more
doaj +2 more sources
Key Metabolic Functions of β-Arrestins: Studies with Novel Mouse Models [PDF]
Trends in Endocrinology and Metabolism, 2021 Sai P Pydi +2 more
exaly +2 more sources