A genetically encoded nanobody sensor reveals conformational diversity in β-arrestins orchestrated by distinct seven transmembrane receptors [PDF]
Proceedings of the National Academy of Sciences of the United States of AmericaAnnu Dalal +2 more
exaly +3 more sources
Differential Regulation of GPCRs—Are GRK Expression Levels the Key?
Frontiers in Cell and Developmental Biology, 2021 G protein-coupled receptors (GPCRs) comprise the largest family of transmembrane receptors and their signal transduction is tightly regulated by GPCR kinases (GRKs) and β-arrestins.
Edda S. F. Matthees +3 more
doaj +1 more source
Frontiers in Endocrinology, 2023 β-arrestins, which have multiple cellular functions, were initially described as proteins that desensitize rhodopsin and other G protein-coupled receptors.
Tibor Szénási +4 more
doaj +1 more source
eLife, 2023 The vasopressin type 2 receptor (V2R) is an essential G protein-coupled receptor (GPCR) in renal regulation of water homeostasis. Upon stimulation, the V2R activates Gαs and Gαq/11, which is followed by robust recruitment of β-arrestins and receptor ...
Carole Daly +6 more
doaj +1 more source
Distinct and shared roles of β-arrestin-1 and β-arrestin-2 on the regulation of C3a receptor signaling in human mast cells. [PDF]
PLoS ONE, 2011 The complement component C3a induces degranulation in human mast cells via the activation of cell surface G protein coupled receptors (GPCR; C3aR).
Arpana Vibhuti +4 more
doaj +1 more source
β-arrestin regulates estradiol membrane-initiated signaling in hypothalamic neurons. [PDF]
, 2015 Estradiol (E2) action in the nervous system is the result of both direct nuclear and membrane-initiated signaling (EMS). E2 regulates membrane estrogen receptor-α (ERα) levels through opposing mechanisms of EMS-mediated trafficking and internalization ...
Abrams, Matthew C +2 more
core +8 more sources
Molecular evidence and clinical importance of β‐arrestins expression in patients with acromegaly [PDF]
Journal of Cellular and Molecular Medicine, 2018 Maria Caroline Alves Coelho +2 more
exaly +2 more sources
Quantification of beta adrenergic receptor subtypes in beta-arrestin knockout mouse airways. [PDF]
PLoS ONE, 2015 In allergic asthma Beta 2 adrenergic receptors (β2ARs) are important mediators of bronchorelaxation and, paradoxically, asthma development. This contradiction is likely due to the activation of dual signaling pathways that are downstream of G proteins or
Akhil Hegde +2 more
doaj +1 more source
Differential Involvement of ACKR3 C-Tail in β-Arrestin Recruitment, Trafficking and Internalization
Cells, 2021 Background: The atypical chemokine receptor 3 (ACKR3) belongs to the superfamily of G protein-coupled receptors (GPCRs). Unlike classical GPCRs, this receptor does not activate G proteins in most cell types but recruits β-arrestins upon activation. ACKR3
Aurélien Zarca +9 more
doaj +1 more source
Itch/β-arrestin2-dependent non-proteolytic ubiquitylation of SuFu controls Hedgehog signalling and medulloblastoma tumorigenesis [PDF]
, 2018 Suppressor of Fused (SuFu), a tumour suppressor mutated in medulloblastoma, is a central player of Hh signalling, a pathway crucial for development and deregulated in cancer.
Alfonsi, Romina +22 more
core +10 more sources