Regulation of mitochondrial oxidative stress by β-arrestins in cultured human cardiac fibroblasts
Disease Models & Mechanisms, 2015 Oxidative stress in cardiac fibroblasts (CFs) promotes transformation to myofibroblasts and collagen synthesis leading to myocardial fibrosis, a precursor to heart failure (HF). NADPH oxidase 4 (Nox4) is a major source of cardiac reactive oxygen species (
Jennifer L. Philip +6 more
doaj +2 more sources
The Viral G Protein-Coupled Receptor ORF74 Hijacks β-Arrestins for Endocytic Trafficking in Response to Human Chemokines. [PDF]
PLoS ONE, 2015 Kaposi's sarcoma-associated herpesvirus-infected cells express the virally encoded G protein-coupled receptor ORF74. Although ORF74 is constitutively active, it binds human CXC chemokines that modulate this basal activity.
Sabrina M de Munnik +7 more
doaj +2 more sources
The Two β-Arrestins Regulate Distinct Metabolic Processes: Studies with Novel Mutant Mouse Models [PDF]
International Journal of Molecular Sciences, 2022 Jürgen Wess
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A genetically encoded nanobody sensor reveals conformational diversity in β-arrestins orchestrated by distinct seven transmembrane receptors [PDF]
Proceedings of the National Academy of Sciences of the United States of AmericaJosef Lazar +2 more
exaly +3 more sources
Delineating the interactions between the cannabinoid CB<sub>2</sub> receptor and its regulatory effectors; β-arrestins and GPCR kinases. [PDF]
Br J Pharmacol, 2022 Background and PurposeThe cannabinoid CB2 receptor (CB2) is a promising therapeutic target for modulating inflammation. However, little is known surrounding the mechanisms underpinning CB2 desensitisation and regulation, particularly the role of G ...
Patel M +6 more
europepmc +3 more sources
Differential Regulation of GPCRs—Are GRK Expression Levels the Key?
Frontiers in Cell and Developmental Biology, 2021 G protein-coupled receptors (GPCRs) comprise the largest family of transmembrane receptors and their signal transduction is tightly regulated by GPCR kinases (GRKs) and β-arrestins.
Edda S. F. Matthees +3 more
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Frontiers in Endocrinology, 2023 β-arrestins, which have multiple cellular functions, were initially described as proteins that desensitize rhodopsin and other G protein-coupled receptors.
Tibor Szénási +4 more
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eLife, 2023 The vasopressin type 2 receptor (V2R) is an essential G protein-coupled receptor (GPCR) in renal regulation of water homeostasis. Upon stimulation, the V2R activates Gαs and Gαq/11, which is followed by robust recruitment of β-arrestins and receptor ...
Carole Daly +6 more
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Distinct and shared roles of β-arrestin-1 and β-arrestin-2 on the regulation of C3a receptor signaling in human mast cells. [PDF]
PLoS ONE, 2011 The complement component C3a induces degranulation in human mast cells via the activation of cell surface G protein coupled receptors (GPCR; C3aR).
Arpana Vibhuti +4 more
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Quantification of beta adrenergic receptor subtypes in beta-arrestin knockout mouse airways. [PDF]
PLoS ONE, 2015 In allergic asthma Beta 2 adrenergic receptors (β2ARs) are important mediators of bronchorelaxation and, paradoxically, asthma development. This contradiction is likely due to the activation of dual signaling pathways that are downstream of G proteins or
Akhil Hegde +2 more
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