Results 41 to 50 of about 9,301 (185)

β-Arrestin-Mediated Signaling Improves the Efficacy of Therapeutics

Journal of Pharmacological Sciences, 2012
β-Arrestins (β-arrestin-1 and β-arrestin-2) were first identified as proteins that have the ability to desensitize G protein-coupled receptors (GPCRs). However, it has recently been found that β-arrestins can activate signaling pathways independent of G ...
Islam A.A.E.-H. Ibrahim, Hitoshi Kurose
doaj   +1 more source

The Viral G Protein-Coupled Receptor ORF74 Hijacks β-Arrestins for Endocytic Trafficking in Response to Human Chemokines. [PDF]

PLoS ONE, 2015
Kaposi's sarcoma-associated herpesvirus-infected cells express the virally encoded G protein-coupled receptor ORF74. Although ORF74 is constitutively active, it binds human CXC chemokines that modulate this basal activity.
Sabrina M de Munnik, Albert J Kooistra, Jody van Offenbeek, Saskia Nijmeijer, Chris de Graaf, Martine J Smit, Rob Leurs, Henry F Vischer   +7 more
doaj   +1 more source

A lipidated peptide derived from the C-terminal tail of the vasopressin 2 receptor shows promise as a new β-arrestin inhibitor

Pharmacological Research
β-arrestins play pivotal roles in seven transmembrane receptor (7TMR) signalling and trafficking. To study their functional role in regulating specific receptor systems, current research relies mainly on genetic tools, as few pharmacological options are ...
Rebecca L. Brouillette, Christine E. Mona, Michael Desgagné, Malihe Hassanzedeh, Émile Breault, Frédérique Lussier, Karine Belleville, Jean-Michel Longpré, Michel Grandbois, Pierre-Luc Boudreault, Élie Besserer-Offroy, Philippe Sarret   +11 more
doaj   +1 more source

G protein-coupled receptors: what a difference a 'partner' makes [PDF]

, 2014
G protein-coupled receptors (GPCRs) are important cell signaling mediators, involved in essential physiological processes. GPCRs respond to a wide variety of ligands from light to large macromolecules, including hormones and small peptides. Unfortunately,
Abu-Helo, Aiyar, Ardura, Attramadal, Babu, Baker, Bartlett, Behrens, Benovic, Benoît Roux, Bermak, Beuming, Björk, Bofill-Cardona, Bomberger, Bornert, Bouschet, Bradbury, Brady, Bretscher, Buck, Buhlmann, Bukau, Bécamel, Cabrera-Vera, Cai, Cao, Caron, Chabre, Chakraborty, Chan, Chen, Cheung, Christopoulos, Christopoulos, Chung, Claing, Clark, Clark, Clark, Colley, Cone, Cook, Cottrell, Cowen, Craig, Dackor, Dackor, Dores, Dunn, Dupré, Dupré, Dwyer, Décaillot, Egea, Ellgaard, Ellis, Evans, Evron, Fam, Ferguson, Ferreira, Fiedler, Fluhmann, Force, Fraser, Fredriksson, Gage, Gardner, Gerke, Gimelbrant, Girard, Goadsby, Graeme Cottrell, Gullapalli, Hamm, Han, Hay, Heydorn, Hilairet, Hilairet, Humrich, Jones, Kadmiel, Kadmiel, Kakiuchi, Kang, Kappeler, Kelley, Kennedy, Kjeldgaard, Kristiansen, Kuang, Kurten, Laburthe, Leclerc, Lee-Kwon, Levitt, Li, Lin, Lohse, Lu, Lucas, Luebke, Lukov, Lutz-Bucher, Ma, Mahon, Mahon, Mahon, Mai, Mancias, Marchese, Marenholz, McClintock, McClintock, McLatchie, Metherell, Miret, Montecucchi, Morello, Mountjoy, Muff, Murphy, Murrell, Málaga-Diéguez, Naghashpour, Nakajima, Nickols, Nikitenko, Nisar, Nishimura, Njuki, Noon, Noorwez, Oh, Oh, Okuse, Oliver, Overgaard, O’Neill, Paquet, Park, Parmentier, Petaja-Repo, Pfeffer, Pittman, Ponting, Prado, Premont, Pálfy, Ritter, Rivero-Müller, Rochdi, Roh, Romero, Rosenblatt, Saito, Sapolsky, Sarkar, Schmidt, Sebag, Sebag, Shenoy, Shieh, Simonin, Sorensen, Spehr, Stamnes, Strasser, Svenningsson, Svenningsson, Tan, Tsujikawa, Turner, Voeltz, Vos, Walther, Wang, Wang, Wang, Wang, Wang, Warner-Schmidt, Warner-Schmidt, Webb, Whistler, Wootten, Yamniuk, Yang, Zobiack   +190 more
core   +4 more sources

Characterizing and predicting the functional and conformational diversity of seven-transmembrane proteins [PDF]

, 2011
The activation of seven-transmembrane receptors (7TMRs) allows cells to sense their environment and convert extracellular signals (like hormone binding) into intracellular signals (through G protein-coupled and/or β arrestin-coupled pathways).
Abrol, Ravinder, Bray, Jenelle K., Goddard, William A., III, Griffith, Adam R., Kim, Soo-Kyung   +4 more
core   +1 more source

β-Arrestin-Dependent Dopaminergic Regulation of Calcium Channel Activity in the Axon Initial Segment

Cell Reports, 2016
G-protein-coupled receptors (GPCRs) initiate a variety of signaling cascades, depending on effector coupling. β-arrestins, which were initially characterized by their ability to “arrest” GPCR signaling by uncoupling receptor and G protein, have recently ...
Sungchil Yang, Roy Ben-Shalom, Misol Ahn, Alayna T. Liptak, Richard M. van Rijn, Jennifer L. Whistler, Kevin J. Bender   +6 more
doaj   +1 more source

Discovery of functionally selective C5aR2 ligands: novel modulators of C5a signalling. [PDF]

, 2016
The complement cascade is comprised of a highly sophisticated network of innate immune proteins that are activated in response to invading pathogens or tissue injury. The complement activation peptide, C5a, binds two seven transmembrane receptors, namely
Blaskovich, M.A., Clark, R.J., Cooper, M.A., Croker, D.E., Floudas, C.A., Halai, R., Kaeslin, G., Monk, P.N., Morikis, D., Schofield, Z., Woodruff, T.M., Wu, M.C.   +11 more
core   +1 more source

β‐Adrenergic Signaling Promotes Anti‐Tumor Immunity in TP53‐mutant Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
β‐adrenergic stimulation enhances anti‐tumor immunity in TP53‐deficient oral squamous cell carcinoma by inducing tumor‐derived secretion of CXCL10, which attracts and activates cytotoxic CD8+ T cells. The findings demonstrate that β‐adrenergic signaling alters tumor–immune interactions via CXCL10‐mediated paracrine activation, revealing a neuro‐immune ...
Frederico O. Gleber‐Netto, Deborah Silverman, Tongxin Xie, Shamima Akhter, Nicole R. Vaughn, Adewale Adebayo, Kala Chand Debnath, Shorook Naara, Shajedul Islam, Erik Knutsen, Emily Lorin Ashkin, Simone Anfossi, Sara Leahey, Patrick Hwu, Sebastien Talbot, Erica K Sloan, Robert Saddawi‐Konefka, Roberto Rangel, Jeffrey N. Myers, George A. Calin, Moran Amit   +20 more
wiley   +1 more source

Regulation of mitochondrial oxidative stress by β-arrestins in cultured human cardiac fibroblasts

Disease Models & Mechanisms, 2015
Oxidative stress in cardiac fibroblasts (CFs) promotes transformation to myofibroblasts and collagen synthesis leading to myocardial fibrosis, a precursor to heart failure (HF). NADPH oxidase 4 (Nox4) is a major source of cardiac reactive oxygen species (
Jennifer L. Philip, Md. Abdur Razzaque, Mei Han, Jinju Li, Tiju Theccanat, Xianyao Xu, Shahab A. Akhter   +6 more
doaj   +1 more source

Beta-Arrestins and Receptor Signaling in the Vascular Endothelium

Biomolecules, 2020
The vascular endothelium is the innermost layer of blood vessels and is a key regulator of vascular tone. Endothelial function is controlled by receptor signaling through G protein-coupled receptors, receptor tyrosine kinases and receptor serine ...
Claudia Lee, Gayathri Viswanathan, Issac Choi, Chanpreet Jassal, Taylor Kohlmann, Sudarshan Rajagopal   +5 more
doaj   +1 more source