Results 51 to 60 of about 871,508 (182)

Methods to Determine Interaction Interfaces Between β-Arrestins and Their Protein Partners

, 2019
International audienceβ-arrestins are so-called hub proteins: they make complexes with many different partners, assembling functional complexes, and thereby fulfilling their biological function.
Crépieux, Pascale, Poupon, Anne, Anne Poupon, Aurélie Tréfier, Musnier, Astrid, Thomas Bourquard, Bourquard, Thomas, Astrid Musnier, Thomas Boulo, Flavie Landomiel, Landomiel, Flavie, Eric Reiter, Boulo, Thomas, Trefier, Aurélie, Pascale Crépieux, Reiter, Eric   +15 more
core   +1 more source

ArreSTick motif controls β-arrestin-binding stability and extends phosphorylation-dependent β-arrestin interactions to non-receptor proteins

Cell Reports
Summary: The binding and function of β-arrestins are regulated by specific phosphorylation motifs present in G protein-coupled receptors (GPCRs).
András Dávid Tóth, Eszter Soltész-Katona, Katalin Kis, Viktor Guti, Sharon Gilzer, Susanne Prokop, Roxána Boros, Ádám Misák, András Balla, Péter Várnai, Lilla Turiák, András Ács, László Drahos, Asuka Inoue, László Hunyady, Gábor Turu   +15 more
doaj   +1 more source

Phase 1, open‐label, randomized study of the elecoglipron pharmacokinetic profile in healthy participants under fed and fasted conditions

British Journal of Clinical Pharmacology, EarlyView.
Aims Elecoglipron (AZD5004/ECC5004) is an oral small‐molecule glucagon‐like peptide‐1 receptor agonist (GLP‐1 RA) in development for weight management in people living with obesity or overweight and type 2 diabetes. This study aimed to characterize the pharmacokinetics (PK) profiles of two formulations of elecoglipron under fed and fasted conditions ...
Jianfeng Xu, Amina Haggag, Laurie Butcher, Haihui Liu, Wen Chen, Xuefeng Sun, Aruni Jha, Hongtao Yu, Anis Khan, Victoria E. R. Parker, Christer Tannergren, Xiaoliang Pan, Jianfeng Xu, Jingye Zhou   +13 more
wiley   +1 more source

β-arrestins and biased signaling in gonadotropin receptors

, 2018
International audienceGonadotropin receptors include the follicle stimulating hormone receptor (FSHR) and the luteinizing hormone/choriogonadotropin receptor (LHCGR), both belong to the G protein- coupled receptor (GPCR) superfamily and being essential ...
de Pascali, Francesco, Reiter, Eric
core   +1 more source

Mortality risk stratification for Takotsubo syndrome: Evaluating CRP measurement alongside the InterTAK prognostic score

ESC Heart Failure, Volume 12, Issue 2, Page 1427-1436, April 2025.
Abstract Background and objectives Initially described as a benign acute cardiomyopathy, Takotsubo syndrome has been linked to elevated mortality rates. Emerging evidence suggests that unresolved myocardial inflammation may contribute to this adverse prognosis.
Loïc Faucher, Kensuke Matsushita, Shinnosuke Kikuchi, Taraneh Tatarcheh, Benjamin Marchandot, Amandine Granier, Said Amissi, Antonin Trimaille, Laurence Jesel, Patrick Ohlmann, Kiyoshi Hibi, Valérie Schini‐Kerth, Olivier Morel   +12 more
wiley   +1 more source

β-arrestin2 in infiltrated macrophages inhibits excessive inflammation after myocardial infarction. [PDF]

PLoS ONE, 2013
Beta-arrestins (β-arrestin1 and β-arrestin2) are known as cytosolic proteins that mediate desensitization and internalization of activated G protein-coupled receptors.
Kenji Watari, Michio Nakaya, Motohiro Nishida, Kyeong-Man Kim, Hitoshi Kurose   +4 more
doaj   +1 more source

Development of a Zebrafish Embryo‐Based Test System for Thyroid Hormone System Disruption: 3Rs in Ecotoxicological Research

Environmental Toxicology and Chemistry, EarlyView.
Abstract There is increasing concern regarding pollutants disrupting the vertebrate thyroid hormone (TH) system, which is crucial for development. Thus, identification of TH system–disrupting chemicals (THSDCs) is an important requirement in the Organisation for Economic Co‐operation and Development (OECD) testing framework.
Lisa Gölz, Melanie Blanc‐Legendre, Maximilian Rinderknecht, Laura Behnstedt, Sara Coordes, Luisa Reger, Sacha Sire, Xavier Cousin, Thomas Braunbeck, Lisa Baumann   +9 more
wiley   +1 more source

The Role of β-Arrestin Proteins in Organization of Signaling and Regulation of the AT1 Angiotensin Receptor

Frontiers in Endocrinology, 2019
AT1 angiotensin receptor plays important physiological and pathophysiological roles in the cardiovascular system. Renin-angiotensin system represents a target system for drugs acting at different levels.
Gábor Turu, Gábor Turu, András Balla, András Balla, László Hunyady, László Hunyady   +5 more
doaj   +1 more source

β-arrestin1 regulates astrocytic reactivity via Drp1-dependent mitochondrial fission: implications in postoperative delirium

Journal of Neuroinflammation, 2023
Postoperative delirium (POD) is a frequent and debilitating complication, especially amongst high risk procedures, such as orthopedic surgery. This kind of neurocognitive disorder negatively affects cognitive domains, such as memory, awareness, attention,
Fuzhou Hua, Hong Zhu, Wen Yu, Qingcui Zheng, Lieliang Zhang, Weidong Liang, Yue Lin, Fan Xiao, Pengcheng Yi, Yanhong Xiong, Yao Dong, Hua Li, Lanran Fang, Hailin Liu, Jun Ying, Xifeng Wang   +15 more
doaj   +1 more source

The Endothelial CXCR Family in Vascular Health and Disease

iNew Medicine, EarlyView.
ABSTRACT Endothelial cells (ECs) form the dynamic interface between blood and tissue, serving as key regulators of vascular homeostasis, inflammation, and repair. Among the molecular systems governing endothelial behavior, the C‐X‐C motif chemokine receptor (CXCR) family—originally characterized in immunology for its roles in leukocyte trafficking and ...
Zhiming Wu, Yandi Wu, Suowen Xu, Yu Huang, Li Wang   +4 more
wiley   +1 more source