Results 71 to 80 of about 871,508 (182)

Agonist-dependent internalization of the angiotensin II type one receptor (AT1): role of C-terminus phosphorylation in recruitment of β-arrestins

, 2004
β-Arrestins play a role in AT1 endocytosis by binding the cytoplasmic, C-terminus region T332–S338, the major site of angiotensin II (Ang II)-induced phosphorylation.
Baker, Kenneth M., Booz, George W., Dinh, Diem, Karoor, Vijaya, Kule, Chris E., Day, Jonathan N. E., Acker, Kathleen A., Thomas, Walter G.   +7 more
core   +1 more source

Functional competence of a partially engaged GPCR–β-arrestin complex

Nature Communications, 2016
β-arrestins initially contact with the phosphorylated carboxyl-terminus of GPCRs before engaging with the GPCR core. Here, the authors use a chimeric GPCR partially and fully engaged with β-arrestin1 and show that the core interaction is dispensable for ...
Punita Kumari, Ashish Srivastava, Ramanuj Banerjee, Eshan Ghosh, Pragya Gupta, Ravi Ranjan, Xin Chen, Bhagyashri Gupta, Charu Gupta, Deepika Jaiman, Arun K. Shukla   +10 more
doaj   +1 more source

Compartmentalisation in cAMP signalling: A phase separation perspective

British Journal of Pharmacology, EarlyView.
Cells rely on precise spatiotemporal control of signalling pathways to ensure functional specificity. The compartmentalisation of cyclic AMP (cAMP) and protein kinase A (PKA) signalling enables distinct cellular responses within a crowded cytoplasmic space.
Milda Folkmanaite, Manuela Zaccolo
wiley   +1 more source

The potential for biased signalling in the P2Y receptor family of GPCRs

British Journal of Pharmacology, EarlyView.
The purinergic receptor family is primarily activated by nucleotides, and contains members of both the G protein coupled‐receptor (GPCR) superfamily (P1 and P2Y) and ligand‐gated ion channels (P2X). The P2Y receptors are widely expressed in the human body, and given the ubiquitous nature of nucleotides, purinergic signalling is involved with a plethora
Claudia M. Sisk, Simon Pitchford, Graham Ladds   +2 more
wiley   +1 more source

PDE4D and PDE3B orchestrate distinct cAMP microdomains in 3T3‐L1 adipocytes

British Journal of Pharmacology, EarlyView.
Basal conditions: •Ins/PDE3B lowers cytoplasmic cAMP (cyt‐cAMP) without affecting plasma membrane cAMP (pm‐cAMP). •Insulin decreases lipid droplet cAMP (LD‐cAMP) independent of PDE3B. •FGF1/PDE4D modestly reduces both cyt‐ and pm‐cAMP, while PDE4D alone can modulate LD‐cAMP. ISO stimulation: •Ins/PDE3B has minimal impact on cyt‐cAMP.
Johannes Krier, David Spähn, David Arturo Juarez Lopez, Judith L. Nono, Judith Seigner, Lisa Jacob, Siegfried Ussar, Robert Lukowski, Andreas L. Birkenfeld, Gencer Sancar   +9 more
wiley   +1 more source

α-Arrestins and Their Functions: From Yeast to Human Health

, 2022
α-Arrestins, also called arrestin-related trafficking adaptors (ARTs), constitute a large family of proteins conserved from yeast to humans. Despite their evolutionary precedence over their extensively studied relatives of the β-arrestin family, α ...
Zbieralski, Kacper, Donata Wawrzycka, Wawrzycka, Donata, Kacper Zbieralski   +3 more
core   +1 more source

Molecular function and targeting of β-arrestins in cancer

, 2012
In the selection leading to cancer, cancer cells make use of the normal extracellular signaling to gain a growth advantage over normal cells. These signals are, in part, generated by plasma membrane receptors.
Huiyuan Zheng (18661996)
core   +1 more source

SNX9 family mediates βarrestin-independent GPCR endocytosis

Communications Biology
Agonist-stimulated GPCR endocytosis typically occurs via the multi-faceted adaptor proteins known as βarrestins. However, endocytosis of several GPCRs occurs independently of β-arrestins, suggesting an additional mode of GPCR endocytosis, but the ...
Valeria L. Robleto, Ya Zhuo, Joseph M. Crecelius, Sara Benzow, Adriano Marchese   +4 more
doaj   +1 more source

The effect of arrestin conformation on the recruitment of c-Raf1, MEK1, and ERK1/2 activation.

PLoS ONE, 2011
Arrestins are multifunctional signaling adaptors originally discovered as proteins that "arrest" G protein activation by G protein-coupled receptors (GPCRs).
Sergio Coffa, Maya Breitman, Susan M Hanson, Kari Callaway, Seunghyi Kook, Kevin N Dalby, Vsevolod V Gurevich   +6 more
doaj   +1 more source

Cannabigerol reverses mechanical allodynia through α2A‐adrenergic modulation of thalamocortical signaling in chemotherapy‐induced neuropathy

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Chemotherapy‐induced peripheral neuropathy (CIPN) is a prevalent and treatment‐resistant side effect of platinum‐based chemotherapy, characterised by mechanical allodynia. Cannabigerol (CBG), a non‐psychoactive cannabinoid, has shown antinociceptive potential, but its site and mechanism of action remain unclear.
Quinn W. Wade, Nathan Morris, Diana E. Sepulveda, Alonso Cortez‐Resendiz, Christopher Brandl, Jennifer E. Lausch, Mariya Starostina, Nicholas M. Graziane   +7 more
wiley   +1 more source