Results 81 to 90 of about 871,508 (182)

ACKR3 Regulation of Neuronal Migration Requires ACKR3 Phosphorylation, but Not β-Arrestin

Cell Reports, 2019
Summary: Phosphorylation of heptahelical receptors is thought to regulate G protein signaling, receptor endocytosis, and non-canonical signaling via recruitment of β-arrestins.
Friederike Saaber, Dagmar Schütz, Elke Miess, Philipp Abe, Srinidhi Desikan, Praveen Ashok Kumar, Sara Balk, Ke Huang, Jean Martin Beaulieu, Stefan Schulz, Ralf Stumm   +10 more
doaj   +1 more source

The nitty‐gritty of vascular permeability in cancer: targeting blood endothelium to control metastases

British Journal of Pharmacology, EarlyView.
Blood vascular permeability is a hallmark of cancer and acts as an active driver of metastatic dissemination. Metastasis accounts for the vast majority of cancer deaths, yet most work has focussed on tumour‐intrinsic traits and angiogenesis, while the specific contribution of endothelial barrier regulation to intravasation and extravasation remains ...
Pierre Boucher, Mérone Da Costa Oliveira, Adrien Levesque, Alexandre Rutault, Patrick Savoyaud, Nicolas Bréchot, Stéphane Germain   +6 more
wiley   +1 more source

The role of β-arrestins in the termination and transduction of G-protein-coupled receptor signals

, 2002
β-arrestins are versatile adapter proteins that form complexes with most G-protein-coupled receptors (GPCRs) following agonist binding and phosphorylation of receptors by G-protein-coupled receptor kinases (GRKs).
Luttrell, Louis M, Lefkowitz, Robert J
core   +1 more source

MRAP2 Inhibits β-Arrestin-2 Recruitment to the Prokineticin Receptor 2

Current Issues in Molecular Biology
Melanocortin receptor accessory protein 2 (MRAP2) is a membrane protein that binds multiple G protein-coupled receptors (GPCRs) involved in the control of energy homeostasis, including prokineticin receptors.
Roberta Lattanzi, Ida Casella, Maria Rosaria Fullone, Daniela Maftei, Martina Vincenzi, Rossella Miele   +5 more
doaj   +1 more source

In silico prediction of novel effective combinational treatment of chronic pain in individual patients: A joint white paper of the H2020 QSPainRelief consortium

British Journal of Pharmacology, EarlyView.
Abstract Opioids are prescribed widely for chronic pain despite well‐recognised risks and variable long‐term benefit, reflecting the lack of effective alternatives for many patients. Combination therapies offer a promising strategy to enhance efficacy whilst reducing side effects.
André Mouraux, Solenn Gousset, Beltrán Alvarez, Monica Baiula, Wouter Bakker, Andrea Bedini, Monir Bertayli, Divakar Budda, Robert Carr, Elisabetta Cuna, Óscar Díaz, Nina Donner, Jesús Giraldo, Geert‐Jan Groeneveld, Berfin Gülave, David Guydan, Hemme Hijma, Rafael Maldonado, Pedro Renault, Carlos Rinaudo, Jeroen Elaissaiss‐Schaap, Athan Spiros, Sara Stoeber, Petri Takkala, Daan van Valkengoed, Coen van Hasselt, Elizabeth (Liesbeth) C.M. de Lange   +26 more
wiley   +1 more source

Distinct phosphorylation sites on the ghrelin receptor, GHSR1a, establish a code that determines the functions of ß-arrestins

, 2016
The growth hormone secretagogue receptor, GHSR1a, mediates the biological activities of ghrelin, which includes the secretion of growth hormone, as well as the stimulation of appetite, food intake and maintenance of energy homeostasis.
R. Nogueiras (7691495), Andrew B. Tobin (7589429), M. Lodeiro (7691492), M. Bouzo-Lorenzo (7691486), A. J. Butcher (7691504), F. F. Casanueva (7691498), M. Castro (677347), Y. Pazos (7691501), I. Santo-Zas (7691489), J. P. Camiña (7691507)   +9 more
core   +5 more sources

Peripheral targets for neuropathic pain

British Journal of Pharmacology, EarlyView.
Neuropathic pain represents a significant clinical challenge, with still limited pharmacological approaches to symptomatic relief. This review focuses on molecular targets implicated in neuropathic pain, particularly those involved in peripheral mechanisms. Using the IUPHAR/BPS database of biological targets, their occurrence together with ‘neuropathic
Amirhossein Afsharipour, Cosmin I. Ciotu, Felix J. Resch, Michael J. M. Fischer   +3 more
wiley   +1 more source

β-arrestins are required for the modulation of Akt phosphorylation in response to ghrelin.

, 2013
A, Effect of siRNA depletion of β-arrestin 1 or β-arrestin 2 on ghrelin-induced Akt phosphorylation. HEK-GHSR1a cells transfected with β-arrestin 1 or β-arrestin 2 siRNA were serum-starved for 12 h and then stimulated with ghrelin (100 nM) at 37°C. After
Felipe F. Casanueva (130305), Maria Pardo (374230), Jesus P. Camiña (5653873), Marily Theodoropoulou (374229), Maria Lodeiro (374228)   +4 more
core   +1 more source

Beta-arrestins operate an on/off control switch for Focal Adhesion Kinase activity

, 2020
International audienceFocal adhesion kinase (FAK) regulates key biological processes downstream of G protein-coupled receptors (GPCRs) in normal and cancer cells, but the modes of kinase activation by these receptors remain unclear.
Alexander, Revu, Ann, Kobayashi, Hiroyuki, Lambert, Mireille, Asnacios, Atef, Scott, Mark, Beautrait, Alexandre, Scott, Mark, G H, Bouvier, Michel, Alexander, Revu Ann, Decosta, Eleonore, Lot, Isaure, Borrull, Aurélie, Saha, Kusumika, Marullo, Stefano, Enslen, Hervé, Abadie, Guillaume   +15 more
core   +1 more source

A new inhibitor of the β-arrestin/AP2 endocytic complex reveals interplay between GPCR internalization and signalling

Nature Communications, 2017
Beta-arrestins play central roles in the mechanisms regulating GPCR signalling and trafficking. Here the authors identify a selective inhibitor of the interaction between β-arrestin and the β2-adaptin subunit of the clathrin adaptor protein AP-2, which ...
Alexandre Beautrait, Justine S. Paradis, Brandon Zimmerman, Jenna Giubilaro, Ljiljana Nikolajev, Sylvain Armando, Hiroyuki Kobayashi, Lama Yamani, Yoon Namkung, Franziska M. Heydenreich, Etienne Khoury, Martin Audet, Philippe P. Roux, Dmitry B. Veprintsev, Stéphane A. Laporte, Michel Bouvier   +15 more
doaj   +1 more source