Results 101 to 110 of about 871,508 (182)

Innovations in Obesity Treatment: Beyond Adipose Tissue Dysfunction

Obesity Reviews, EarlyView.
Obesity drives chronic inflammation, insulin resistance, type 2 diabetes, and cancer development through adipocyte dysfunction. Addressing this multisystemic disorder requires integrated strategies beyond diet and exercise, such as thermogenesis activation via menthol or capsinoids and appetite control through GLP‐1/GIP agonists and neuromodulation to ...
Jesica Martínez‐Godfrey, Irene Pomares‐Bri, Paula de Juan‐Maciá, Mariló Olivares‐Vicente, Enrique Barrajón‐Catalán, Vicente Micol, Enrique Roche, María Herranz‐López   +7 more
wiley   +1 more source

True arrestins and arrestin-fold proteins: a structure-based appraisal.

, 2013
International audienceArrestin-clan proteins are folded alike, a feature responsible for their recent grouping in a single clan. In human, it includes the well-characterized visual and β-arrestins, the arrestin domain-containing proteins (ARRDCs ...
Klein, Gérard, Laurence Aubry, Aubry, Laurence, Gérard Klein   +3 more
core   +1 more source

Epigenetic Dysregulation of Somatostatin Receptors (SSTR) 1–5 and Therapeutic Implications in Neuroendocrine and Non‐Neuroendocrine Malignancies

International Journal of Cancer, Volume 159, Issue 11, Page 2633-2652, 1 December 2026.
ABSTRACT Somatostatin receptors (SSTR) mediate the antiproliferative, antisecretory, and proapoptotic effects of somatostatin and its synthetic analogs. Their surface expression on neuroendocrine tumor (NET) cells is required for somatostatin analog therapy and radiopharmaceutical therapy (RPT).
Neeraj Kumari, Pablo Hoffmann, Laura Reichl, Maximilian Schmutz, Nina Fischer, Thi Tuong Vi Dang, Fulvia Ferrazzi, Pascal Johann, Michaela Kuhlen, Constantin Lapa, Rainer Claus   +10 more
wiley   +1 more source

V1b vasopressin receptor trafficking and signaling: Role of arrestins, G proteins and Src kinase

, 2018
International audienceThe signaling pathway of G protein-coupled receptors is strongly linked to their trafficking profile. Little is known about the molecular mechanisms involved in the vasopressin receptor V1b subtype (V1b R) trafficking and its impact
Ayoub, Mohammed Akli, Hemery, Floriane, Mendre, Christiane, Li, Juan, Laguette, Nadine, Ventura, Maria Angeles, Ayoub, M. A., Durroux, Thierry, Ventura, Maria-Angeles, Corbani, Maithé, Perkovska, Sanja, Orcel, Hélène, Mouillac, Bernard, Méjean, Catherine   +13 more
core   +1 more source

Arrestins in host-pathogen interactions. [PDF]

, 2013
International audienceIn the context of host-pathogen interaction, host cell receptors and signaling pathways are essential for both invading pathogens, which exploit them for their own profit, and the defending organism, which activates early mechanism ...
Marullo, Stefano, Mathieu Coureuil, Coureuil, Mathieu, Stefano Marullo   +3 more
core   +1 more source

Adrenergic Contraction of Human Prostate Tissues Is Maintained Under the Rab GTPase Inhibitors Nexhinib20 and CID1067700

Pharmacology Research &Perspectives, Volume 14, Issue 6, December 2026.
ABSTRACT α1‐Adrenoceptors are an important drug target in benign prostatic hyperplasia (BPH) and have been intensively studied at the expression level, but their posttranslational regulation in the prostate is widely unknown. Here we examined modulation of prostate smooth muscle contractions by inhibitors for RabGTPases, which are involved in ...
Luca Troffer, Peibin Cen, Michael Brandstetter, Yajie Xu, Patrick Keller, Leo Stadelmeier, Philipp Weinhold, Alexander Tamalunas, Christian G. Stief, Martin Hennenberg   +9 more
wiley   +1 more source

Non-canonical internalization mechanisms of mGlu receptors

Cell Reports
Summary: Cell surface G protein-coupled receptors (GPCRs) are tightly regulated through constitutive and agonist-induced internalization. While the mechanisms of constitutive internalization remain elusive, agonist-induced internalization very often ...
Marta Cimadevila, Junke Liu, Damien Maurel, Isabelle Brabet, Marine Hoscar, Julia Drube, Carsten Hoffmann, Asuka Inoue, Philippe Rondard, Pierre-André Lafon, Laurent Prézeau, Jean-Philippe Pin   +11 more
doaj   +1 more source

GPCRs and β-arrestins - an on-off relationship. [PDF]

Cell Res, 2023
Thomsen ARB.
europepmc   +1 more source

Renin‐Angiotensin Signaling and Vascular Function: Insights into Health and Disease

Acta Physiologica, Volume 242, Issue 11, November 2026.
ABSTRACT The renin‐angiotensin system (RAS) is an essential regulator of vascular structure and function, and dysregulation of angiotensin II (Ang II) signaling plays a critical role in the development of hypertension and associated vascular complications.
Giovanni Bertoldi, Swapnil K. Sonkusare
wiley   +1 more source

Mechanisms of XCR1 Membrane Trafficking and Constitutive Endocytosis

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 5, November 2026.
ABSTRACT Chemokines orchestrate immune cell trafficking through receptor‐mediated signalling and are implicated in inflammatory, autoimmune and neuropathic disorders. The XCL1–XCR1 axis is of particular interest because XCR1 is selectively expressed on mature conventional type 1 dendritic cells (cDC1s), where it supports communication with activated ...
Qiao Li, Fabian Pfersdorf, Fernando Salgado‐Polo, Martin Gustavsson   +3 more
wiley   +1 more source