Results 121 to 130 of about 871,508 (182)

Progress report on new epilepsy treatments: A summary of the Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XVIII). II. Treatments in more advanced clinical development

Epilepsia, Volume 67, Issue 10, Page 5075-5125, October 2026.
Abstract This article summarizes data for 13 investigational treatments for which at least preliminary seizure outcome data in patients with epilepsy were reported at the Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices held in Madrid, Spain, on May 3–6, 2026.
Meir Bialer, Cecilie Johannessen Landmark, Matthias J. Koepp, Emilio Perucca, Piero Perucca, Torbjörn Tomson, H. Steve White, Elaine Wirrell   +7 more
wiley   +1 more source

Catalytic activation of beta-arrestins allows novel trafficking and signaling functions [PDF]

, 2017
This thesis examines the trafficking and signaling functions of beta-arrestins, a highly conserved class of proteins that are critical regulators of G protein coupled receptor function (GPCRs), a large family of seven-transmembrane signaling receptors ...
Eichel, Kelsie
core  

Prognostic value of β-Arrestins in combination with glucocorticoid receptor in epithelial ovarian cancer. [PDF]

Front Oncol, 2023
Ryu JW, Shin HY, Kim HS, Han GH, Kim JW, Lee HN, Cho H, Chung JY, Kim JH.   +8 more
europepmc   +1 more source

Senescent Cell‐Derived Extracellular Vesicles in Therapy‐Induced Senescence: Immune Remodelling and Emerging Links to Mitochondrial Stress in Cancer

Journal of Extracellular Biology, Volume 5, Issue 10, October 2026.
ABSTRACT Cancer therapy can induce cellular senescence and remodel the tumour microenvironment through the senescence‐associated secretory phenotype (SASP), including its membrane‐enclosed component, senescent cell‐derived extracellular vesicles (senEVs). This review summarizes senEV biogenesis, cargo‐dependent functions, and immune‐remodelling effects
Yongrui Qian, Zirui Weng, Na Li, Yun Zhou, Hailong Pei   +4 more
wiley   +1 more source

β-arrestins and G protein-coupled receptor kinases in viral entry: A graphical review. [PDF]

Cell Signal, 2023
Maginnis MS.
europepmc   +1 more source

G Protein‐Coupled Receptor in High‐Altitude Diseases: Mechanistic Insights and Therapeutic Opportunities

MedComm, Volume 7, Issue 10, October 2026.
High‐altitude hypobaric hypoxia activates multiorgan GPCR signaling networks that regulate ventilatory responses, cerebral endothelial barrier integrity, erythropoiesis and red blood cell metabolism, pulmonary vascular remodeling, and cardiac adaptation. Dysregulated GPCR pathways contribute to acute and chronic high‐altitude diseases, while clinically
Qing Zhao, Changliang Liu, Lu Dai, Kun Zheng, Kun Liang, Chuanling Pan, Lianhua Liu, Ling Chen, Xuefei He, Hui Yan, Lei Chen, Huaping Zheng, Cheng Deng, Fengming Luo   +13 more
wiley   +1 more source

Comparative interactome analysis of α-arrestin families in human and Drosophila

eLife
The α-arrestins form a large family of evolutionally conserved modulators that control diverse signaling pathways, including both G-protein-coupled receptor (GPCR)-mediated and non-GPCR-mediated pathways, across eukaryotes.
Kyung-Tae Lee, Inez KA Pranoto, Soon-Young Kim, Hee-Joo Choi, Ngoc Bao To, Hansong Chae, Jeong-Yeon Lee, Jung-Eun Kim, Young V Kwon, Jin-Wu Nam   +9 more
doaj   +1 more source

Naltrexone, Naloxone, Morphine, and Fentanyl Pharmacologically Chaperone a Mutant μ‐Opioid Receptor via an Endoplasmic Reticulum Exit Site‐Dependent Pathway

Pharmacology Research &Perspectives, Volume 14, Issue 5, October 2026.
ABSTRACT Opioid receptor antagonists increase the plasma membrane density of μ‐opioid receptors (MOR) in vivo, thereby inducing “supersensitivity” to opioid agonists. This phenomenon increases the risk of overdose in patients that were being treated with naltrexone (Ntx), a popular MOR antagonist.
Stephen N. Grant, Matthew J. Mulcahy, Henry A. Lester   +2 more
wiley   +1 more source

Scaffolding of Mitogen-Activated Protein Kinase Signaling by β-Arrestins. [PDF]

Int J Mol Sci, 2022
Kim K, Han Y, Duan L, Chung KY.
europepmc   +1 more source

Glucagon‐Like Peptide‐1 Agonists and Blood Pressure Regulation: Molecular Mechanisms and Cardiovascular Implications

Pharmacology Research &Perspectives, Volume 14, Issue 5, October 2026.
ABSTRACT Incretin effect helps in regulating glucose homeostasis and maintaining glycaemic control within the human body. This effect is achieved by the two naturally occurring incretin hormones: glucose‐dependent insulinotropic polypeptide (GIP) and glucagon‐like peptide‐1 (GLP‐1).
Nora H. J. Alharbi
wiley   +1 more source