Results 131 to 140 of about 871,508 (182)

An Acidic Tubulointerstitial Microenvironment Delays Cell‐Cycle Progression in Proximal Tubule Cells and Fibroblasts and Synergizes With Lactate to Drive Phenotypic Alterations

Acta Physiologica, Volume 242, Issue 10, October 2026.
ABSTRACT Background Chronic kidney disease (CKD) is characterized by progressive tubulointerstitial inflammation and fibrosis, particularly affecting the proximal tubule. Both proximal tubular epithelial cells and interstitial fibroblasts contribute to CKD progression through cell‐cycle arrest and phenotypic transitions.
Marie‐Christin Schulz, Virginie Dubourg, Lea Schaude, Natalie Schröder, Eva Janßen, Isabelle Görlich, Stefanie Ruhs, Michael Kopf, Michael Gekle   +8 more
wiley   +1 more source

Decoding functional specialization in G protein‐coupled receptors (GPCRs) through evolution‐guided residue profiling

British Journal of Pharmacology, Volume 183, Issue 20, Page 6007-6027, October 2026.
Background and Purpose G protein‐coupled receptors (GPCRs) are integral membrane proteins that mediate physiological processes by enabling cells to detect and respond to diverse stimuli. Although many subfamily‐specific functional hotspots have been described, the family‐wide determinants of common and subfamily‐specific functions remain incomplete ...
Berkay Selçuk, Gunnar Schulte, Igor B. Zhulin, Ogün Adebali   +3 more
wiley   +1 more source

Determining the Effects of Differential Expression of GRKs and β-arrestins on CLR-RAMP Agonist Bias. [PDF]

Front Physiol, 2022
Pearce A, Redfern-Nichols T, Harris M, Poyner DR, Wigglesworth M, Ladds G.   +5 more
europepmc   +1 more source

Cannabinoid CB1 allosteric ligands suppress inflammatory pain in male mice without tolerance, motor impairment, memory deficits or respiratory depression

British Journal of Pharmacology, Volume 183, Issue 20, Page 6132-6153, October 2026.
Abstract Background and Purpose Positive allosteric modulators (PAMs) engage sites distinct from the orthosteric CB1 cannabinoid receptor binding site. GAT211, a racemic ligand, contains GAT228 (R) and GAT229 (S) enantiomers. Whether enantiomer‐mediated differences in allosteric activation or positive allosteric modulation translate into differences in
Ifeoluwa D. Solomon, Sumanta Garai, Ganesh A. Thakur, Andrea G. Hohmann   +3 more
wiley   +1 more source

Molecular function and targeting of β-arrestins in cancer [Elektronisk resurs]

, 2012
In the selection leading to cancer, cancer cells make use of the normal extracellular signaling to gain a growth advantage over normal cells. These signals are, in part, generated by plasma membrane receptors.
Zheng, H
core  

A calorimetric study of β-sultams and β-lactams [PDF]

The hydrolytic degradation of a series of β-sultams and β-lactams was investigated using isothermal microcalorimetry (IMC), to determine kinetic and enthalpic data.
Naz, Summia
core   +2 more sources

Predictors of in vitro response to somatostatin and dopamine receptor‐targeted treatments are lacking in clinically non‐functioning pituitary tumors

Journal of Neuroendocrinology, Volume 38, Issue 10, October 2026.
Abstract Clinically non‐functioning pituitary neuroendocrine tumors (NF‐PitNETs) lack effective medical therapies, and the role of somatostatin receptor ligands (SRLs) and dopamine agonists (DAs) in this setting is controversial. We evaluated the in vitro response of NF‐PitNETs to multiple SRL and/or DA treatments, focusing on the role of receptor ...
Claudia Campana, Jessica Amarù, Diego Criminelli Rossi, Anna Arecco, Paolo Nozza, Mara Boschetti, Gianluigi Zona, Diego Ferone, Marica Arvigo, Federico Gatto   +9 more
wiley   +1 more source

<i>β</i>-Arrestins: Structure, Function, Physiology, and Pharmacological Perspectives. [PDF]

Pharmacol Rev, 2023
Wess J, Oteng AB, Rivera-Gonzalez O, Gurevich EV, Gurevich VV.   +4 more
europepmc   +1 more source

TLR4 signaling cascades leading to increases in albumin permeability, nephrin ectodomain shedding, and apoptosis in MPC‐5 podocytes

Physiological Reports, Volume 14, Issue 20, October 2026.
Activation of TLR4 receptors in cultured podocytes evokes multiple functional responses which occur over different time scales, including an increase in albumin permeability (1), shedding of nephrin ectodomains (2) and apoptosis (3). Each of these responses requires a distinct set of intracellular signaling pathways.
Eun Young Kim, Stuart E. Dryer
wiley   +1 more source

Molecular mechanism of β-arrestin-2 pre-activation by phosphatidylinositol 4,5-bisphosphate

EMBO Reports
Phosphorylated residues of G protein-coupled receptors bind to the N-domain of arrestin, resulting in the release of its C-terminus. This induces further allosteric conformational changes, such as polar core disruption, alteration of interdomain loops ...
Kiae Kim, Ka Young Chung
doaj   +1 more source