The FASEB Journal, Volume 40, Issue 9, 15 May 2026.scRNA‐seq of human adipose and diabetic wounds revealed a CCL2+ ADSC subpopulation with high stemness and ECM‐enriched pathways. These cells serve as a signaling hub via TGFB1‐TGFBR1, IL34‐CSF1R, and CCL2‐ACKR1. Their exosomes (CCL2‐Exos), carrying CCL2, TGFB1, and IL34, accelerate diabetic wound healing in mice by promoting angiogenesis, collagen ...
Songyun Zhao +10 more
wiley +1 more source
Comparative interactome analysis of α-arrestin families in human and Drosophila
eLifeThe α-arrestins form a large family of evolutionally conserved modulators that control diverse signaling pathways, including both G-protein-coupled receptor (GPCR)-mediated and non-GPCR-mediated pathways, across eukaryotes.
Kyung-Tae Lee +9 more
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Scaffolding of Mitogen-Activated Protein Kinase Signaling by β-Arrestins. [PDF]
Int J Mol Sci, 2022 Kim K, Han Y, Duan L, Chung KY.
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Determining the Effects of Differential Expression of GRKs and β-arrestins on CLR-RAMP Agonist Bias. [PDF]
Front Physiol, 2022 Pearce A +5 more
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<i>β</i>-Arrestins: Structure, Function, Physiology, and Pharmacological Perspectives. [PDF]
Pharmacol Rev, 2023 Wess J +4 more
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The Two β-Arrestins Regulate Distinct Metabolic Processes: Studies with Novel Mutant Mouse Models. [PDF]
Int J Mol Sci, 2022 Wess J.
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Molecular mechanism of β-arrestin-2 pre-activation by phosphatidylinositol 4,5-bisphosphate
EMBO ReportsPhosphorylated residues of G protein-coupled receptors bind to the N-domain of arrestin, resulting in the release of its C-terminus. This induces further allosteric conformational changes, such as polar core disruption, alteration of interdomain loops ...
Kiae Kim, Ka Young Chung
doaj +1 more source
Functional and structural insights into interactions between β-Arrestin 1 and Gαs or Gαi1
Nature CommunicationsG proteins and arrestins are key transducers for G protein-coupled receptor (GPCR) signaling, mediating distinct downstream pathways. Recent evidence suggests that G proteins and β-arrestins (βarrs) can directly or functionally interact.
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Delineating the interactions between the cannabinoid CB<sub>2</sub> receptor and its regulatory effectors; β-arrestins and GPCR kinases. [PDF]
Br J Pharmacol, 2022 Patel M +6 more
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Glycogen Synthase Kinase-3 is an Intermediate Modulator of Serotonin Neurotransmission [PDF]
, 2011 Abigail M. Polter, Xiaohua Li
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