Results 111 to 120 of about 871,508 (182)
The FASEB Journal, Volume 40, Issue 19, 15 October 2026.Beta‐Arrestin‐2 but not Beta‐Arrestin‐1 can accumulate in the nucleolus and come in close contact with the Nucleolar Organizing Regions during two distinct processes: P2X7 receptor stimulation (A) and cell division (B). Both seem to be due to loss of nuclear membrane barrier that keeps Beta‐arrestin‐2 out of the nucleus.
Tuğba Gümüştaş +4 more
wiley +1 more source
Angewandte Chemie, Volume 138, Issue 42, 12 October 2026.Durch einen strukturbasierten Designansatz wurden photoschaltbare Derivate des von der FDA zugelassenen Arzneistoffes Suvorexant entwickelt, gedockt, synthetisiert und pharmakologisch an den Orexin‐1‐ und 2‐Rezeptoren (OX1R und OX2R) charakterisiert.
Marcus Angermann +10 more
wiley +1 more source
Nature CommunicationsG protein-coupled receptors (GPCRs) orchestrate diverse physiological responses via signaling through G proteins, GPCR kinases (GRKs), and arrestins.
Edda S. F. Matthees +10 more
doaj +1 more source
Hepatic β-arrestins: potential roles in liver health and disease. [PDF]
Mol Biol Rep, 2023 Eissa AM, Hassanin MH, Ibrahim IAAEH.
europepmc +1 more source
Angewandte Chemie International Edition, Volume 65, Issue 42, 12 October 2026.Following a structure‐based design approach, photoswitchable derivatives of the FDA‐approved drug suvorexant were designed, docked, synthesized, and characterized pharmacologically at the orexin 1 and 2 receptors (OX1R and OX2R). Optimized “photorexant” showed up to an 11‐fold difference in IC50 between photoisomers, enabled dynamic and reversible ...
Marcus Angermann +10 more
wiley +1 more source
Interplay of β-arrestins and Nedd4 E3 ligase regulates ubiquitination and trafficking of mGluR7 [PDF]
, 2018 학위논문 (석사)-- 서울대학교 대학원 : 의과대학 의과학과, 2018. 2. 서영호.Metabotropic glutamate receptor 7A belongs to group III of metabotropic glutamate receptors as a G protein-coupled receptor.
이효진
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An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, Volume 600, Issue 19, Page 2876-2898, October 2026.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Emerging paradigms of β-arrestin-dependent seven transmembrane receptor signaling
, 2011 β-arrestins, originally discovered to desensitize activated seven transmembrane receptors (7TMRs; also known as G protein-coupled receptors [GPCRs]), are now well established mediators of receptor endocytosis, ubiquitylation and G protein-independent ...
Robert J. Lefkowitz +5 more
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Ciliary Membrane Lipid Homeostasis in Health and Disease
Advanced Science, Volume 13, Issue 58, 19 October 2026.This review systematically delineates the distinct lipid landscapes of ciliary membranes, including the spatial organization of phosphoinositides, cholesterol, and sphingolipids. It elucidates how these lipids orchestrate ciliogenesis, signal transduction, and membrane dynamics in cilia beating, and highlights how their dysregulation drives ...
Zhenzhou Huang +3 more
wiley +1 more source
Arrestins: multifunctional regulators of signaling pathways
, 2019 The four vertebrate arrestins comprise a family of proteins that are responsible for the desensitization and internalization of over 800 subtypes of G protein-coupled receptors (GPCRs). The arrestins also serve as independent signal transducers in both a
Perry-Hauser, Nicole Anna
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