Results 31 to 40 of about 871,508 (182)

Biased signaling of the angiotensin II type 1 receptor can be mediated through distinct mechanisms. [PDF]

PLoS ONE, 2010
Seven transmembrane receptors (7TMRs) can adopt different active conformations facilitating a selective activation of either G protein or β-arrestin-dependent signaling pathways.
Marie Mi Bonde, Jonas Tind Hansen, Samra Joke Sanni, Stig Haunsø, Steen Gammeltoft, Christina Lyngsø, Jakob Lerche Hansen   +6 more
doaj   +1 more source

β-arrestins and endocrine-related GPCRs

, 2021
International audienceG protein-coupled receptors (GPCRs) allow target cells to respond to a wide array of hormones. Mounting evidences point to GPCRs being functionally coupled to multiple transduction mechanisms, some of them not involving ...
Yvinec, Romain, Crépieux, Pascale, Poupon, Anne, de Pascali, Francesco, Bozon, Véronique, Jean-Alphonse, Frédéric, Pellissier, Lucie P., Anne Poupon, Bruneau, Gilles, Frédéric Jean-Alphonse, Francesco De Pascali, Gilles Bruneau, Lucie P. Pellissier, Pauline Raynaud, Romain Yvinec, Eric Reiter, Tahir, Shifa, Shifa Tahir, Véronique Bozon, Pascale Crépieux, Raynaud, Pauline, Reiter, Eric   +21 more
core   +1 more source

β-arrestin1 and 2 exhibit distinct phosphorylation-dependent conformations when coupling to the same GPCR in living cells

Nature Communications, 2022
Here the authors present improved intramolecular sensors for β-arrestin2 and 1, which enable assessment of conformational changes of both isoforms in living cells.
Raphael S. Haider, Edda S. F. Matthees, Julia Drube, Mona Reichel, Ulrike Zabel, Asuka Inoue, Andy Chevigné, Cornelius Krasel, Xavier Deupi, Carsten Hoffmann   +9 more
doaj   +1 more source

Nedd4 E3 ligase and beta-arrestins regulate ubiquitination, trafficking, and stability of the mGlu7 receptor

eLife, 2019
The metabotropic glutamate receptor 7 (mGlu7) is a class C G protein-coupled receptor that modulates excitatory neurotransmitter release at the presynaptic active zone. Although post-translational modification of cellular proteins with ubiquitin is a key
Sanghyeon Lee, Sunha Park, Hyojin Lee, Seulki Han, Jae-man Song, Dohyun Han, Young Ho Suh   +6 more
doaj   +1 more source

β-Arrestin-Mediated Signaling Improves the Efficacy of Therapeutics

Journal of Pharmacological Sciences, 2012
β-Arrestins (β-arrestin-1 and β-arrestin-2) were first identified as proteins that have the ability to desensitize G protein-coupled receptors (GPCRs). However, it has recently been found that β-arrestins can activate signaling pathways independent of G ...
Islam A.A.E.-H. Ibrahim, Hitoshi Kurose
doaj   +1 more source

G Protein-Coupled Receptor Kinase 2 Selectively Enhances β-Arrestin Recruitment to the D₂ Dopamine Receptor through Mechanisms That Are Independent of Receptor Phosphorylation

Biomolecules, 2023
The D2 dopamine receptor (D2R) signals through both G proteins and β-arrestins to regulate important physiological processes, such as movement, reward circuitry, emotion, and cognition.
Marta Sánchez-Soto, Noelia M. Boldizsar, Kayla A. Schardien, Nora S. Madaras, Blair K. A. Willette, Laura R. Inbody, Christopher Dasaro, Amy E. Moritz, Julia Drube, Raphael S. Haider, R. Benjamin Free, Carsten Hoffman, David R. Sibley   +12 more
doaj   +1 more source

Homo- and Hetero-oligomerization of β-Arrestins in Living Cells

, 2005
International audienceArrestins are important proteins, which regulate the function of serpentine heptahelical receptors and contribute to multiple signaling pathways downstream of receptors.
Muntaner, Olivier, Bouvier, Michel, Labbé-Jullié, Catherine, Tramier, Marc, Issafras, Hassan, Burtey, Anne, Benmerah, Alexandre, Marullo, Stefano, Storez, Hélène, Scott, Mark G.H., Piolot, Tristan, Coppey-Moisan, Maité   +11 more
core   +1 more source

A lipidated peptide derived from the C-terminal tail of the vasopressin 2 receptor shows promise as a new β-arrestin inhibitor

Pharmacological Research
β-arrestins play pivotal roles in seven transmembrane receptor (7TMR) signalling and trafficking. To study their functional role in regulating specific receptor systems, current research relies mainly on genetic tools, as few pharmacological options are ...
Rebecca L. Brouillette, Christine E. Mona, Michael Desgagné, Malihe Hassanzedeh, Émile Breault, Frédérique Lussier, Karine Belleville, Jean-Michel Longpré, Michel Grandbois, Pierre-Luc Boudreault, Élie Besserer-Offroy, Philippe Sarret   +11 more
doaj   +1 more source

Single‐Cell Transcriptomics and Metabolomics Reveal Glutamate Dehydrogenase as a Central Regulator of Nitrogen Metabolic Remodeling During Alkalinity Adaptation in Crustaceans

Advanced Science, EarlyView.
Single‐cell transcriptomics reveals the cellular response of Macrobrachium hainanense to carbonate alkalinity stress. Alkalinity stress impairs branchial ammonia excretion, induces mitochondrial dysfunction, and drives cell‐type‐specific changes in gills and hemocytes.
Yiting Jin, Zhimin Lv, Chao Bian, Qibin Yang, Na Zhou, Jianguang Qin, Shengming Sun   +6 more
wiley   +1 more source

β-Arrestin-Dependent Dopaminergic Regulation of Calcium Channel Activity in the Axon Initial Segment

Cell Reports, 2016
G-protein-coupled receptors (GPCRs) initiate a variety of signaling cascades, depending on effector coupling. β-arrestins, which were initially characterized by their ability to “arrest” GPCR signaling by uncoupling receptor and G protein, have recently ...
Sungchil Yang, Roy Ben-Shalom, Misol Ahn, Alayna T. Liptak, Richard M. van Rijn, Jennifer L. Whistler, Kevin J. Bender   +6 more
doaj   +1 more source