Results 31 to 40 of about 9,301 (185)

Novel mechanisms of G-protein-coupled receptors functions: AT1 angiotensin receptor acts as a signaling hub and focal point of receptor cross-talk [PDF]

, 2018
AT1 angiotensin receptor (AT1R), a prototypical G protein-coupled receptor (GPCR), is the main receptor, which mediates the effects of the renin-angiotensin system (RAS).
Balla, András, Hunyady, László, Turu, Gábor, Tóth, András D.   +3 more
core   +1 more source

Identification of chemokine receptors as potential modulators of endocrine resistance in oestrogen receptor–positive breast cancers [PDF]

, 2014
Introduction Endocrine therapies target oestrogenic stimulation of breast cancer (BC) growth, but resistance remains problematic. Our aims in this study were (1) to identify genes most strongly associated with resistance to endocrine therapy by ...
A Boudot, A Levoye, AE Gururaj, AH Evans, AK Dunbier, Anita Dunbier, Aradhana Rani, AS Coutts, B Györffy, BC Nair, CA Moore, CM Chan, DG Duda, EA Musgrove, F Andre, GJ Sabnis, H Shankar, H Zheng, J Kang, J Xu, JM Burns, K Hattermann, K Sauvé, KE Luker, LA Martin, LA Martin, LA Martin, Lesley-Ann Martin, LV Rhodes, M Dowsett, Mitch Dowsett, MJ Ellis, MR Hara, MT Weigel, N Lapteva, OE Hawkins, Qiong Gao, R Santen, RD Berahovich, Ricardo Ribas, RK Singh, S Ali, S Masamura, S Masri, S Rajagopal, SE Ghayad, SM DeWire, Sunil Pancholi, TJ Frederick, TN Hartmann, V Lakshmikanthan, Y Shi, YC Su, Z Liang, Zara Ghazoui   +54 more
core   +1 more source

β-arrestin1 and 2 exhibit distinct phosphorylation-dependent conformations when coupling to the same GPCR in living cells

Nature Communications, 2022
Here the authors present improved intramolecular sensors for β-arrestin2 and 1, which enable assessment of conformational changes of both isoforms in living cells.
Raphael S. Haider, Edda S. F. Matthees, Julia Drube, Mona Reichel, Ulrike Zabel, Asuka Inoue, Andy Chevigné, Cornelius Krasel, Xavier Deupi, Carsten Hoffmann   +9 more
doaj   +1 more source

The α-Arrestin ARRDC3 Regulates the Endosomal Residence Time and Intracellular Signaling of the β2-Adrenergic Receptor. [PDF]

, 2016
Arrestin domain-containing protein 3 (ARRDC3) is a member of the mammalian α-arrestin family, which is predicted to share similar tertiary structure with visual-/β-arrestins and also contains C-terminal PPXY motifs that mediate interaction with E3 ...
Benovic, Jeffrey L., Bowman, Shanna L., Du, Yang, Irannejad, Roshanak, Puthenveedu, Manojkumar A., Tian, Xufan, von Zastrow, Mark   +6 more
core   +2 more sources

Differential Signaling Profiles of MC4R Mutations with Three Different Ligands [PDF]

, 2020
The melanocortin 4 receptor (MC4R) is a key player in hypothalamic weight regulation and energy expenditure as part of the leptin-melanocortin pathway. Mutations in this G protein coupled receptor (GPCR) are the most common cause for monogenetic obesity,
Annibale, Paolo, Biebermann, Heike, Dimitriou, Ioanna Maria, Krude, Heiko, Kühnen, Peter, Lohse, Martin J., Paisdzior, Sarah, Scheerer, Patrick, Schöpe, Paul Curtis   +8 more
core   +3 more sources

Nedd4 E3 ligase and beta-arrestins regulate ubiquitination, trafficking, and stability of the mGlu7 receptor

eLife, 2019
The metabotropic glutamate receptor 7 (mGlu7) is a class C G protein-coupled receptor that modulates excitatory neurotransmitter release at the presynaptic active zone. Although post-translational modification of cellular proteins with ubiquitin is a key
Sanghyeon Lee, Sunha Park, Hyojin Lee, Seulki Han, Jae-man Song, Dohyun Han, Young Ho Suh   +6 more
doaj   +1 more source

Antagonism of the proinflammatory and pronociceptive actions of canonical and biased agonists of protease-activated receptor-2 [PDF]

, 2016
Diverse proteases cleave protease-activated receptor-2 (PAR2) on primary sensory neurons and epithelial cells to evoke pain and inflammation. Trypsin and tryptase activate PAR2 by a canonical mechanism that entails cleavage within the extracellular N ...
Barlow, N., Bron, R., Bunnett, N. W., Edgington-Mitchell, L., Fairlie, D. P., Lieu, T., Lohman, R. -J., Mclean, P., Poole, D. P., Savage, E., Zhao, P.   +10 more
core   +2 more sources

G Protein-Coupled Receptor Kinase 2 Selectively Enhances β-Arrestin Recruitment to the D₂ Dopamine Receptor through Mechanisms That Are Independent of Receptor Phosphorylation

Biomolecules, 2023
The D2 dopamine receptor (D2R) signals through both G proteins and β-arrestins to regulate important physiological processes, such as movement, reward circuitry, emotion, and cognition.
Marta Sánchez-Soto, Noelia M. Boldizsar, Kayla A. Schardien, Nora S. Madaras, Blair K. A. Willette, Laura R. Inbody, Christopher Dasaro, Amy E. Moritz, Julia Drube, Raphael S. Haider, R. Benjamin Free, Carsten Hoffman, David R. Sibley   +12 more
doaj   +1 more source

Dynamin function is important for chemokine receptor-induced cell migration. [PDF]

, 2015
The HIV viral entry co-receptors CCR5 and CXCR4 function physiologically as typical chemokine receptors. Activation leads to cytosolic signal transduction that results in a variety of cellular responses such as cytoskeletal rearrangement and chemotaxis ...
Arai, Bachelerie, Borroni, Casoli, Chua, De Camilli, Delgado-Martin, Drury, Ferguson, Gallo, Germena, Harper, Harper, Hill, Homey, Kawada, Kerr, Lagane, Lee, Loetscher, Magalhaes, Mariani, McCluskey, McGeachie, Meiser, Mueller, Mueller, Mueller, Rajagopal, Rajagopal, Sabroe, Scott, Shpetner, Tadagaki, Thelen, Tomizawa, Zhang, Zlotnik, Zlotnik   +38 more
core   +1 more source

Contribution of a tyrosine-based motif to cellular trafficking of wild-type and truncated NPY Y(1) receptors. [PDF]

, 2011
peer reviewedThe human NPY Y(1) receptor undergoes fast agonist-induced internalization via clathrin-coated pits then recycles back to the cell membrane.
Bucher, Bernard, Cherrier, Thomas, Galzi, Jean-Luc, Glasser, Nicole, Lecat, Sandra, Mely, Yves, Noulet, Fanny, Ouedraogo, Moussa, Ronde, Philippe, Takeda, Kenneth   +9 more
core   +4 more sources