Results 21 to 30 of about 9,301 (185)

β-Arrestin regulation of myosin light chain phosphorylation promotes AT1aR-mediated cell contraction and migration. [PDF]

PLoS ONE, 2013
Over the last decade, it has been established that G-protein-coupled receptors (GPCRs) signal not only through canonical G-protein-mediated mechanisms, but also through the ubiquitous cellular scaffolds β-arrestin-1 and β-arrestin-2.
Elie Simard, Jeffrey J Kovacs, William E Miller, Jihee Kim, Michel Grandbois, Robert J Lefkowitz   +5 more
doaj   +1 more source

Select G-Protein-Coupled Receptors Modulate Agonist-Induced Signaling via a ROCK, LIMK, and β-Arrestin 1 Pathway

Cell Reports, 2013
G-protein-coupled receptors (GPCRs) are typically present in a basal, inactive state but, when bound to an agonist, activate downstream signaling cascades. In studying arrestin regulation of opioid receptors in dorsal root ganglia (DRG) neurons, we find that agonists of delta opioid receptors (δORs) activate cofilin through Rho-associated coiled-coil ...
Mittal, N, Roberts, K, Pal, K, Bentolila, LA, Fultz, E, Minasyan, A, Cahill, C, Pradhan, A, Conner, D, DeFea, K, Evans, C, Walwyn, W   +11 more
openaire   +6 more sources

The α-arrestin ARRDC3 mediates ALIX ubiquitination and G protein-coupled receptor lysosomal sorting. [PDF]

, 2015
The sorting of G protein-coupled receptors (GPCRs) to lysosomes is critical for proper signaling and cellular responses. We previously showed that the adaptor protein ALIX regulates lysosomal degradation of protease-activated receptor-1 (PAR1), a GPCR ...
Dores, Michael R, J Grimsey, Neil, Lin, Huilan, Mendez, Francisco, Trejo, JoAnn   +4 more
core   +1 more source

Endocrinology and the brain: Corticotropin-Releasing Hormone signaling [PDF]

, 2017
Corticotropin-releasing hormone (CRH) is a key player of basal and stress activated responses in the hypothalamic-pituitary-adrenal axis (HPA) and in extrahypothalamic circuits, where it functions as a neuromodulator to orchestrate humoral and behavioral
Armando, Natalia Giannina, Dos Santos Claro, Paula Ayelen, Inda, María Carolina, Silberstein Cuña, Susana Iris   +3 more
core   +2 more sources

Ubiquitin-mediated regulation of endocytosis by proteins of the arrestin family [PDF]

, 2013
This is an open access article distributed under the Creative Commons Attribution License.-- et al.In metazoans, proteins of the arrestin family are key players of G-protein-coupled receptors (GPCRS) signaling and trafficking.
Becuwe, Michel, Herrador, Antonio, Vincent, Olivier   +2 more
core   +2 more sources

Mammalian α arrestins link activated seven transmembrane receptors to Nedd4 family e3 ubiquitin ligases and interact with β arrestins. [PDF]

PLoS ONE, 2012
The complement of fungal cell surface proteins is widely regulated by ubiquitination of membrane proteins, which results in their endocytosis and vacuolar degradation.
Fortune F Shea, Jennie L Rowell, Yechaowei Li, Tien-Hsien Chang, Carlos E Alvarez   +4 more
doaj   +1 more source

Differential β-arrestin2 requirements for constitutive and agonist-induced internalization of the CB1 cannabinoid receptor [PDF]

, 2013
CB1 cannabinoid receptor (CB1R) undergoes both constitutive and agonist-induced internalization, but the underlying mechanisms of these processes and the role of beta-arrestins in the regulation of CB1R function are not completely understood.
Ahn, Bakshi, Bari, Brailoiu, Coutts, Daigle, Daigle, Dale, Derkinderen, DeWire, Eszter Boros, Fan, Ferguson, Ferguson, Freund, Gaborik, Graham, Guan, Gyombolai, Gábor Turu, Holliday, Hsieh, Hunyady, Jin, Keren, Kleyer, Kouznetsova, Krupnick, Leterrier, Leterrier, László Hunyady, Marullo, McDonald, McDonald, Nguyen, Oakley, Oakley, Pacher, Paing, Parent, Pál Gyombolai, Rinaldi-Carmona, Roche, Rozenfeld, Rozenfeld, Sanchez, Shenoy, Singh, Szekeres, Tohgo, Toth, Turu, Turu, Turu, Turu, Valjent, Varnai, Vines, Ward, Ward, Wei, Woo, Wu, Zhang, Zhao   +64 more
core   +1 more source

Phosphorylation-deficient G-protein-biased μ-opioid receptors improve analgesia and diminish tolerance but worsen opioid side effects [PDF]

, 2019
Opioid analgesics are powerful pain relievers; however, over time, pain control diminishes as analgesic tolerance develops. The molecular mechanisms initiating tolerance have remained unresolved to date.
Bailey, A, Bateman, JT, Christie, MJ, Kliewer, A, Levitt, ES, Schmiedel, F, Schulz, S, Sianati, S, Williams, JT   +8 more
core   +2 more sources

Unraveling the molecular architecture of a G protein-coupled receptor/β-arrestin/Erk module complex [PDF]

, 2015
International audienceβ-arrestins serve as signaling scaffolds downstream of G protein-coupled receptors, and thus play a crucial role in a plethora of cellular processes.
Azé, Jérôme, Bourquard, Thomas, Crépieux, Pascale, Landomiel, Flavie, Poupon, Anne, Reiter, Eric, Ritchie, David W.   +6 more
core   +4 more sources

Biased signaling of the angiotensin II type 1 receptor can be mediated through distinct mechanisms. [PDF]

PLoS ONE, 2010
Seven transmembrane receptors (7TMRs) can adopt different active conformations facilitating a selective activation of either G protein or β-arrestin-dependent signaling pathways.
Marie Mi Bonde, Jonas Tind Hansen, Samra Joke Sanni, Stig Haunsø, Steen Gammeltoft, Christina Lyngsø, Jakob Lerche Hansen   +6 more
doaj   +1 more source