Results 61 to 70 of about 9,354 (195)

Regulation of the orexin 1 receptor by beta-arrestins [PDF]

, 2004
The orexin 1 receptor was identified as an orphan G protein-coupled receptor (GPCR) in 1998 (Sakurai et ah, 1998). There is great interest in the orexin receptor system since it is involved in the control of feeding and energy metabolism (Sakurai et al ...
Milasta, Sandra
core  

-Arrestins as Important Regulators of Glucose and Energy Homeostasis

, 2022
-Arrestin-1 and -2 (also known as arrestin-2 and -3, respectively) are ubiquitously expressed cytoplasmic proteins that dampen signaling through G protein-coupled receptors. However, -arrestins can also act as signaling molecules in their own right.
Pydi S. P., Meister J., Rossi M., Wess J., Barella L. F., Zhu L.   +5 more
core   +1 more source

GPCR Signaling Regulation: The Role of GRKs and Arrestins

Frontiers in Pharmacology, 2019
Every animal species expresses hundreds of different G protein-coupled receptors (GPCRs) that respond to a wide variety of external stimuli. GPCRs-driven signaling pathways are involved in pretty much every physiological function and in many pathologies.
Vsevolod V. Gurevich, Eugenia V. Gurevich   +1 more
doaj   +1 more source

Beta-Arrestins and Receptor Signaling in the Vascular Endothelium

Biomolecules, 2020
The vascular endothelium is the innermost layer of blood vessels and is a key regulator of vascular tone. Endothelial function is controlled by receptor signaling through G protein-coupled receptors, receptor tyrosine kinases and receptor serine ...
Claudia Lee, Gayathri Viswanathan, Issac Choi, Chanpreet Jassal, Taylor Kohlmann, Sudarshan Rajagopal   +5 more
doaj   +1 more source

Structural Determinants of Arrestin Functions [PDF]

, 2013
Arrestins are a small protein family with only four members in mammals. Arrestins demonstrate an amazing versatility, interacting with hundreds of different G protein-coupled receptor (GPCR) subtypes, numerous nonreceptor signaling proteins, and components of the internalization machinery, as well as cytoskeletal elements, including regular ...
Vsevolod V, Gurevich, Eugenia V, Gurevich   +1 more
openaire   +2 more sources

β-Arrestin-Dependent Dopaminergic Regulation of Calcium Channel Activity in the Axon Initial Segment

Cell Reports, 2016
G-protein-coupled receptors (GPCRs) initiate a variety of signaling cascades, depending on effector coupling. β-arrestins, which were initially characterized by their ability to “arrest” GPCR signaling by uncoupling receptor and G protein, have recently ...
Sungchil Yang, Roy Ben-Shalom, Misol Ahn, Alayna T. Liptak, Richard M. van Rijn, Jennifer L. Whistler, Kevin J. Bender   +6 more
doaj   +1 more source

RNAi targeting Caenorhabditis elegans α-arrestins marginally affects lifespan

, 2017
Background: α-arrestins are a family of proteins that are implicated in multiple biological processes, including metabolism and receptor desensitization.
Murat Artan, Dae-Eun Jeong, Hae-Eun H. Park, Sangsoon Park, Dongyeop Lee, Seung-Jae V. Lee, Heehwa G. Son, Seon Woo A. An, Yujin Lee, Wooseon Hwang, Yoonji Jung   +10 more
core   +1 more source

Scaffolding of Mitogen-Activated Protein Kinase Signaling by β-Arrestins

, 2022
β-arrestins were initially identified to desensitize and internalize G-protein-coupled receptors (GPCRs). Receptor-bound β-arrestins also initiate a second wave of signaling by scaffolding mitogen-activated protein kinase (MAPK) signaling ...
Yeonjin Han, Ka Young Chung, Longhan Duan, Kiae Kim   +3 more
core   +1 more source

ArreSTick motif controls β-arrestin-binding stability and extends phosphorylation-dependent β-arrestin interactions to non-receptor proteins

Cell Reports
Summary: The binding and function of β-arrestins are regulated by specific phosphorylation motifs present in G protein-coupled receptors (GPCRs).
András Dávid Tóth, Eszter Soltész-Katona, Katalin Kis, Viktor Guti, Sharon Gilzer, Susanne Prokop, Roxána Boros, Ádám Misák, András Balla, Péter Várnai, Lilla Turiák, András Ács, László Drahos, Asuka Inoue, László Hunyady, Gábor Turu   +15 more
doaj   +1 more source

Light intensity-dependent arrestin switching for inactivation of a light-sensitive GPCR, bistable opsin

iScience
Summary: Inactivation of most light-sensitive G protein-coupled receptor (GPCR) opsins involves arrestin binding to terminate cell responses. In the zebrafish pineal organ, UV sensitive parapinopsin 1 (PP1)-expressing cells exhibit color opponency ...
Baoguo Shen, Seiji Wada, Tomohiro Sugihara, Takashi Nagata, Haruka Nishioka, Emi Kawano-Yamashita, Takeaki Ozawa, Mitsumasa Koyanagi, Akihisa Terakita   +8 more
doaj   +1 more source