Results 81 to 90 of about 9,354 (195)
A human alpha-arrestin protein with a potential role in cargo protein trafficking within the endocytic system [PDF]
β-Arrestins are essential adaptors for G protein-coupled receptor (GPCR) trafficking. Evolutionary ancestors of the β-arrestins – dubbed α-arrestins – are present in yeast/fungi and, similar to β-arrestins, recognise cargo proteins and mediate their ...
Lake, David Jonathan
core
Nature Communications, 2017 Beta-arrestins have key roles in development and metabolic functions as euglycaemic control and insulin sentitivity. Here Zhuet al. show that beta-arrestin-2 regulates insulin secretion and glucose tolerance in mice by promoting CAMKII functions in beta ...
Lu Zhu +22 more
doaj +1 more source
Functional specialization of beta-arrestin interactions revealed by proteomic analysis
, 2007 Beta-arrestins are cytosolic proteins that form complexes with seven-transmembrane receptors after agonist stimulation and phosphorylation by the G protein-coupled receptor kinases. They play an essential role in receptor desensitization and endocytosis,
Yates, John R. +15 more
core +1 more source
Arrestins regulate cell spreading and motility via focal adhesion dynamics
, 2012 Arrestins bind G protein-coupled receptors and more than 100 non-receptor partners, regulating various signaling pathways and cellular functions. The interactions of many proteins (e.g., Src, JNK3, ERK½, Mdm2, etc.) with receptor-bound arrestin localize ...
Cleghorn, Whitney Marie
core
Arrestins in Host–Pathogen Interactions
, 2013 In the context of host-pathogen interaction, host cell receptors and signaling pathways are essential for both invading pathogens, which exploit them for their own profit, and the defending organism, which activates early mechanism of defense, known as innate immunity, to block the aggression.
Marullo, Stefano, Coureuil, Mathieu
openaire +4 more sources
RNAi targeting Caenorhabditis elegans α-arrestins has little effect on lifespan
, 2017 Background: α-arrestins are a family of proteins that are implicated in multiple biological processes, including metabolism and receptor desensitization.
Murat Artan +10 more
core +1 more source
Arrestins: multifunctional regulators of signaling pathways
, 2019 The four vertebrate arrestins comprise a family of proteins that are responsible for the desensitization and internalization of over 800 subtypes of G protein-coupled receptors (GPCRs). The arrestins also serve as independent signal transducers in both a
Perry-Hauser, Nicole Anna
core
Subcellular localization of alpha arrestins.
, 2012 Vasopressin receptor 2 HA-V2R-V5-stably transfected HEK293T cells were transiently transfected with expression constructs of alpha arrestins with C-terminal fusions of fluorescent protein mCherry.
Tien-Hsien Chang (112560) +4 more
core +1 more source
Arresting a Transient Receptor Potential (TRP) Channel
, 2010 β-Arrestins, originally discovered to desensitize activated G protein-coupled receptors, (aka seven-transmembrane receptors, 7TMRs) also mediate 7TMR internalization and G protein-independent signaling via these receptors.
Robert J. Lefkowitz +13 more
core +1 more source
, 2008 Arrestins mediate G protein-coupled receptor desensitization, internalization, and signaling. Dopamine D2 and D3 receptors have similar structures but distinct characteristics of interaction with arrestins.
Michal I. Bell +4 more
core