Results 91 to 100 of about 9,354 (195)

Angiotensin II-mediated Signaling in Astrocytes: Role of Beta-arrestins

, 2017
Hypertension is the major risk factor that plays a crucial role in damaging vital organs leading to cardiovascular diseases. It has been demonstrated that the brain renin-angiotensin system (RAS) plays a central role in the development and establishment ...
Lymperopoulos, Anastasios, Negussie, Shmuel, Clark, Michelle A.   +2 more
core   +1 more source

MRAP2 Inhibits β-Arrestin-2 Recruitment to the Prokineticin Receptor 2

Current Issues in Molecular Biology
Melanocortin receptor accessory protein 2 (MRAP2) is a membrane protein that binds multiple G protein-coupled receptors (GPCRs) involved in the control of energy homeostasis, including prokineticin receptors.
Roberta Lattanzi, Ida Casella, Maria Rosaria Fullone, Daniela Maftei, Martina Vincenzi, Rossella Miele   +5 more
doaj   +1 more source

beta-arrestin control of late endosomal sorting facilitates decoy receptor function and chemokine gradient formation.

, 2012
Item does not contain fulltextA crucial regulator of Cxcl12 is the decoy receptor Cxcr7, which controls the level of the chemokine in the tissue. The molecular mechanisms that enable Cxcr7 to function as an efficient molecular sink are not known.
Nowak, M., Raz, E., Mahabaleshwar, H., Brand, M., Tarbashevich, K.   +4 more
core   +1 more source

Methods to Determine Interaction Interfaces Between β-Arrestins and Their Protein Partners

, 2019
International audienceβ-arrestins are so-called hub proteins: they make complexes with many different partners, assembling functional complexes, and thereby fulfilling their biological function.
Crépieux, Pascale, Poupon, Anne, Anne Poupon, Aurélie Tréfier, Musnier, Astrid, Thomas Bourquard, Bourquard, Thomas, Astrid Musnier, Thomas Boulo, Flavie Landomiel, Landomiel, Flavie, Eric Reiter, Boulo, Thomas, Trefier, Aurélie, Pascale Crépieux, Reiter, Eric   +15 more
core   +1 more source

How Ligands Achieve Biased Signaling toward Arrestins

G protein-coupled receptors (GPCRs) mediate the effects of various endogenous and extracellular stimuli through multiple transducers, including heterotrimeric G proteins, GPCR kinases (GRKs), and arrestins.
Che, Tao, Jiang, Qianru
core   +1 more source

β-Arrestin condensates regulate G-protein-coupled receptor function. [PDF]

Nature
Anderson PJ, Xiao P, Zhong YN, Kaakati AN, Alfonso-DeSouza J, Patino A, Ahn A, Jassal C, Zhang T, Zhang C, Yu K, Qi L, Ding W, Liu S, Pani B, Krishnan A, Chen O, Strawn J, Snyder JC, Sun JP, Rajagopal S.   +20 more
europepmc   +1 more source

Arrestin-g pain [PDF]

Nature Chemical Biology, 2019
openaire   +2 more sources

Arrestins as programmable integrators of GPCR signaling: structural microstates, spatiotemporal logic, and therapeutic control. [PDF]

Cell Discov
He Q, Zhao LH, Xu HE.
europepmc   +1 more source

Location-biased β-arrestin conformations direct GPCR signaling. [PDF]

Sci Signal
Pham U, Chundi A, Stępniewski TM, Darbha S, Eiger DS, Gazula S, Gardner J, Hicks C, Selent J, Rajagopal S.   +9 more
europepmc   +1 more source

Is the arrestin of a primitive chordates, ascidian a common ancestor of vertebrate visual arrestin and β-arrestin?

Seibutsu Butsuri, 2001
M. Nakagawa, H. Orii, T. Horie, R. Yoshida, M. Tsuda   +4 more
openaire   +1 more source