Results 91 to 100 of about 17,943 (269)

Characterisation and expression of β1-, β2- and β3-adrenergic receptors in the fathead minnow (Pimephales promelas) [PDF]

, 2011
This is the author’s version of a work that was accepted for publication in General and Comparative Endocrinology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control ...
Eccles, PD, Giltrow, E, Hutchinson, TH, Rand-Weaver, M, Sumpter, JP   +4 more
core   +1 more source

Compartmentalisation in cAMP signalling: A phase separation perspective

British Journal of Pharmacology, EarlyView.
Cells rely on precise spatiotemporal control of signalling pathways to ensure functional specificity. The compartmentalisation of cyclic AMP (cAMP) and protein kinase A (PKA) signalling enables distinct cellular responses within a crowded cytoplasmic space.
Milda Folkmanaite, Manuela Zaccolo
wiley   +1 more source

G protein-coupled receptors: what a difference a 'partner' makes [PDF]

, 2014
G protein-coupled receptors (GPCRs) are important cell signaling mediators, involved in essential physiological processes. GPCRs respond to a wide variety of ligands from light to large macromolecules, including hormones and small peptides. Unfortunately,
Abu-Helo, Aiyar, Ardura, Attramadal, Babu, Baker, Bartlett, Behrens, Benovic, Benoît Roux, Bermak, Beuming, Björk, Bofill-Cardona, Bomberger, Bornert, Bouschet, Bradbury, Brady, Bretscher, Buck, Buhlmann, Bukau, Bécamel, Cabrera-Vera, Cai, Cao, Caron, Chabre, Chakraborty, Chan, Chen, Cheung, Christopoulos, Christopoulos, Chung, Claing, Clark, Clark, Clark, Colley, Cone, Cook, Cottrell, Cowen, Craig, Dackor, Dackor, Dores, Dunn, Dupré, Dupré, Dwyer, Décaillot, Egea, Ellgaard, Ellis, Evans, Evron, Fam, Ferguson, Ferreira, Fiedler, Fluhmann, Force, Fraser, Fredriksson, Gage, Gardner, Gerke, Gimelbrant, Girard, Goadsby, Graeme Cottrell, Gullapalli, Hamm, Han, Hay, Heydorn, Hilairet, Hilairet, Humrich, Jones, Kadmiel, Kadmiel, Kakiuchi, Kang, Kappeler, Kelley, Kennedy, Kjeldgaard, Kristiansen, Kuang, Kurten, Laburthe, Leclerc, Lee-Kwon, Levitt, Li, Lin, Lohse, Lu, Lucas, Luebke, Lukov, Lutz-Bucher, Ma, Mahon, Mahon, Mahon, Mai, Mancias, Marchese, Marenholz, McClintock, McClintock, McLatchie, Metherell, Miret, Montecucchi, Morello, Mountjoy, Muff, Murphy, Murrell, Málaga-Diéguez, Naghashpour, Nakajima, Nickols, Nikitenko, Nisar, Nishimura, Njuki, Noon, Noorwez, Oh, Oh, Okuse, Oliver, Overgaard, O’Neill, Paquet, Park, Parmentier, Petaja-Repo, Pfeffer, Pittman, Ponting, Prado, Premont, Pálfy, Ritter, Rivero-Müller, Rochdi, Roh, Romero, Rosenblatt, Saito, Sapolsky, Sarkar, Schmidt, Sebag, Sebag, Shenoy, Shieh, Simonin, Sorensen, Spehr, Stamnes, Strasser, Svenningsson, Svenningsson, Tan, Tsujikawa, Turner, Voeltz, Vos, Walther, Wang, Wang, Wang, Wang, Wang, Warner-Schmidt, Warner-Schmidt, Webb, Whistler, Wootten, Yamniuk, Yang, Zobiack   +190 more
core   +3 more sources

The potential for biased signalling in the P2Y receptor family of GPCRs

British Journal of Pharmacology, EarlyView.
The purinergic receptor family is primarily activated by nucleotides, and contains members of both the G protein coupled‐receptor (GPCR) superfamily (P1 and P2Y) and ligand‐gated ion channels (P2X). The P2Y receptors are widely expressed in the human body, and given the ubiquitous nature of nucleotides, purinergic signalling is involved with a plethora
Claudia M. Sisk, Simon Pitchford, Graham Ladds   +2 more
wiley   +1 more source

GPCR Signaling Regulation: The Role of GRKs and Arrestins

Frontiers in Pharmacology, 2019
Every animal species expresses hundreds of different G protein-coupled receptors (GPCRs) that respond to a wide variety of external stimuli. GPCRs-driven signaling pathways are involved in pretty much every physiological function and in many pathologies.
Vsevolod V. Gurevich, Eugenia V. Gurevich   +1 more
doaj   +1 more source

Role of G protein-coupled receptor kinases in cell migration [PDF]

, 2014
G protein-coupled receptor kinases (GRKs) are emerging as important integrative nodes in cell migration processes. Recent evidence links GRKs (particularly the GRK2 isoform) to the complex modulation of diverse aspects of cell motility.
Mayor, Federico, Nogués, Laura, Penela, Petronila   +2 more
core   +2 more sources

PDE4D and PDE3B orchestrate distinct cAMP microdomains in 3T3‐L1 adipocytes

British Journal of Pharmacology, EarlyView.
Basal conditions: •Ins/PDE3B lowers cytoplasmic cAMP (cyt‐cAMP) without affecting plasma membrane cAMP (pm‐cAMP). •Insulin decreases lipid droplet cAMP (LD‐cAMP) independent of PDE3B. •FGF1/PDE4D modestly reduces both cyt‐ and pm‐cAMP, while PDE4D alone can modulate LD‐cAMP. ISO stimulation: •Ins/PDE3B has minimal impact on cyt‐cAMP.
Johannes Krier, David Spähn, David Arturo Juarez Lopez, Judith L. Nono, Judith Seigner, Lisa Jacob, Siegfried Ussar, Robert Lukowski, Andreas L. Birkenfeld, Gencer Sancar   +9 more
wiley   +1 more source

β-Arrestin-Mediated Signaling Improves the Efficacy of Therapeutics

Journal of Pharmacological Sciences, 2012
β-Arrestins (β-arrestin-1 and β-arrestin-2) were first identified as proteins that have the ability to desensitize G protein-coupled receptors (GPCRs). However, it has recently been found that β-arrestins can activate signaling pathways independent of G ...
Islam A.A.E.-H. Ibrahim, Hitoshi Kurose
doaj   +1 more source

Cannabigerol reverses mechanical allodynia through α2A‐adrenergic modulation of thalamocortical signaling in chemotherapy‐induced neuropathy

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Chemotherapy‐induced peripheral neuropathy (CIPN) is a prevalent and treatment‐resistant side effect of platinum‐based chemotherapy, characterised by mechanical allodynia. Cannabigerol (CBG), a non‐psychoactive cannabinoid, has shown antinociceptive potential, but its site and mechanism of action remain unclear.
Quinn W. Wade, Nathan Morris, Diana E. Sepulveda, Alonso Cortez‐Resendiz, Christopher Brandl, Jennifer E. Lausch, Mariya Starostina, Nicholas M. Graziane   +7 more
wiley   +1 more source

β-Arrestin-Dependent Dopaminergic Regulation of Calcium Channel Activity in the Axon Initial Segment

Cell Reports, 2016
G-protein-coupled receptors (GPCRs) initiate a variety of signaling cascades, depending on effector coupling. β-arrestins, which were initially characterized by their ability to “arrest” GPCR signaling by uncoupling receptor and G protein, have recently ...
Sungchil Yang, Roy Ben-Shalom, Misol Ahn, Alayna T. Liptak, Richard M. van Rijn, Jennifer L. Whistler, Kevin J. Bender   +6 more
doaj   +1 more source