Results 71 to 80 of about 9,354 (195)

Mast cell tryptase controls paracellular permeability of the intestine: role of protease-activated receptor 2 and beta-arrestins

, 2005
Tight junctions between intestinal epithelial cells prevent ingress of luminal macromolecules and bacteria and protect against inflammation and infection.
Darmoul, D., Singh, P., Yang, P.-C., Nigel W. Bunnett, Amadesi, Silvia, Grady, E. F., Toshiyuki Saito, Mary Perdue, Bunnett, N. W., Ping-Chang Yang, Anne-Marie Coelho, Graeme S. Cottrell, Silvia Amadesi, Eileen F. Grady, Claire Jacob, Saito, T., Jacob, C., Dalila Darmoul, Cottrell, Graeme S., Coelho, A.-M., Pamela Singh, Perdue, M.   +21 more
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Different internalization properties of the alpha1a- and alpha1b-adrenergic receptor subtypes: the potential role of receptor interaction with beta-arrestins and AP50.

, 2008
The internalization properties of the alpha1a- and alpha1b-adrenergic receptors (ARs) subtypes transiently expressed in human embryonic kidney (HEK) 293 cells were compared using biotinylation experiments and confocal microscopy.
Abuin, L., Cotecchia, S., Stanasila, L., Dey, J.   +3 more
core   +1 more source

Therapeutic Targets for Treatment of Heart Failure: Focus on GRKs and β-Arrestins Affecting βAR Signaling

Frontiers in Pharmacology, 2018
Heart failure (HF) is a heart disease that is classified into two main types: HF with reduced ejection fraction (HFrEF) and HF with preserved ejection fraction (HFpEF). Both types of HF lead to significant risk of mortality and morbidity. Pharmacological
Supachoke Mangmool, Warisara Parichatikanond, Hitoshi Kurose   +2 more
doaj   +1 more source

Comparative interactome analysis of α-arrestin families in human and Drosophila

eLife
The α-arrestins form a large family of evolutionally conserved modulators that control diverse signaling pathways, including both G-protein-coupled receptor (GPCR)-mediated and non-GPCR-mediated pathways, across eukaryotes.
Kyung-Tae Lee, Inez KA Pranoto, Soon-Young Kim, Hee-Joo Choi, Ngoc Bao To, Hansong Chae, Jeong-Yeon Lee, Jung-Eun Kim, Young V Kwon, Jin-Wu Nam   +9 more
doaj   +1 more source

Homo- and Hetero-oligomerization of β-Arrestins in Living Cells

, 2005
International audienceArrestins are important proteins, which regulate the function of serpentine heptahelical receptors and contribute to multiple signaling pathways downstream of receptors.
Muntaner, Olivier, Bouvier, Michel, Labbé-Jullié, Catherine, Tramier, Marc, Issafras, Hassan, Burtey, Anne, Benmerah, Alexandre, Marullo, Stefano, Storez, Hélène, Scott, Mark G.H., Piolot, Tristan, Coppey-Moisan, Maité   +11 more
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Regulation of immune receptor functional responses by G protein-coupled receptor kinases (GRKs) and arrestins [PDF]

, 2001
Biological systems consistently diminish their responses to persistent or stable stimuli, in a process termed desensitisation or adaptation. This study focuses on the process called “homologous desensitisation” that indicates the rapid and reversible ...
Mariggió, Stefania Pasqua
core   +1 more source

SNX9 family mediates βarrestin-independent GPCR endocytosis

Communications Biology
Agonist-stimulated GPCR endocytosis typically occurs via the multi-faceted adaptor proteins known as βarrestins. However, endocytosis of several GPCRs occurs independently of β-arrestins, suggesting an additional mode of GPCR endocytosis, but the ...
Valeria L. Robleto, Ya Zhuo, Joseph M. Crecelius, Sara Benzow, Adriano Marchese   +4 more
doaj   +1 more source

Distinct functional outputs of PTEN signalling are controlled by dynamic association with β-arrestins

, 2011
The tumour suppressor PTEN (phosphatase and tensin deleted on chromosome 10) regulates major cellular functions via lipid phosphatase-dependent and -independent mechanisms.
George S Baillie, Larissa Kotelevets, Boularan, C., Julie A Pitcher, Camand, E., Kotelevets, L., Chastre, E., Pitcher, J.A., Scott, M.G.H., Lima-Fernandes, E., Achour, L., Emeline Camand, Enslen, H., Baillie, G.S., Lamia Achour, Evelyne Lima-Fernandes, Marullo, S., Benmerah, A., Stefano Marullo, Mark G H Scott, Etienne-Manneville, S., Cédric Boularan, Eric Chastre, Gibson, L.C.D., Hervé Enslen, Alexandre Benmerah, Lucien C D Gibson, Sandrine Etienne-Manneville   +27 more
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Expression of β-arrestins in toxic and cold thyroid nodules [PDF]

, 2000
β-Arrestins mediate agonist dependent desensitization of G protein-coupled receptors. Somatic TSH receptor mutations were identified in the majority of hot thyroid nodules.
Ralf Paschke, Holzapfel, Hans-Peter, Hans-Peter Holzapfel, Carsten Voigt, Voigt, Carsten, Paschke, Ralf   +5 more
core   +1 more source

Structural basis of arrestin-3 activation and signaling

Nature Communications, 2017
While arrestins are mainly associated with GPCR signaling, arrestin-3 can signal independently of receptor interaction. Here the authors present the structure of arrestin-3 bound to inositol hexakisphosphate (IP6) and propose a model for arrestin-3 ...
Qiuyan Chen, Nicole A. Perry, Sergey A. Vishnivetskiy, Sandra Berndt, Nathaniel C. Gilbert, Ya Zhuo, Prashant K. Singh, Jonas Tholen, Melanie D. Ohi, Eugenia V. Gurevich, Chad A. Brautigam, Candice S. Klug, Vsevolod V. Gurevich, T. M. Iverson   +13 more
doaj   +1 more source