Results 51 to 60 of about 9,354 (195)
Arrestin Development: Emerging Roles for β-arrestins in Developmental Signaling Pathways [PDF]
Developmental Cell, 2009 Arrestins were identified as mediators of G protein-coupled receptor (GPCR) desensitization and endocytosis. However, it is now clear that they scaffold many intracellular signaling networks to modulate the strength and duration of signaling by diverse types of receptors--including those relevant to the Hedgehog, Wnt, Notch, and TGFbeta pathways--and ...
Kovacs, Jeffrey J. +4 more
openaire +2 more sources
FYVE-dependent endosomal targeting of an arrestin-related protein in amoeba. [PDF]
PLoS ONE, 2010 BACKGROUND: Visual and β-arrestins are scaffolding proteins involved in the regulation of receptor-dependent intracellular signaling and their trafficking.
Dorian Guetta +4 more
doaj +1 more source
Experimental and Molecular MedicineArrestins are multifunctional proteins that regulate G-protein-coupled receptor (GPCR) desensitization, signaling, and internalization. The arrestin family consists of four subtypes: visual arrestin1, β-arrestin1, β-arrestin2, and visual arrestin-4 ...
Teresa R. Kee +7 more
doaj +1 more source
eLife, 2019 The metabotropic glutamate receptor 7 (mGlu7) is a class C G protein-coupled receptor that modulates excitatory neurotransmitter release at the presynaptic active zone. Although post-translational modification of cellular proteins with ubiquitin is a key
Sanghyeon Lee +6 more
doaj +1 more source
Mécanismes de l'internalisation du récepteur CCK2 : bases pharmacologiques et structurales [PDF]
, 2011 Le récepteur CCK2 est un récepteur couplé aux protéines G (RCPG) possédant deux ligands naturels, la cholécystokinine et la gastrine, retrouvées au niveau du système nerveux central et du système gastro-intestinal. Le récepteur CCK2 est impliqué dans de
Magnan, Rémi
core
Frontiers in Pharmacology, 2019 Arrestin translocation and signaling have come to the fore of the G protein-coupled receptor molecular pharmacology field. Some receptor–arrestin interactions are relatively well understood and considered responsible for specific therapeutic or adverse ...
Mikkel Søes Ibsen +9 more
doaj +1 more source
Uncovering missing pieces: duplication and deletion history of arrestins in deuterostomes
BMC Evolutionary Biology, 2017 Background The cytosolic arrestin proteins mediate desensitization of activated G protein-coupled receptors (GPCRs) via competition with G proteins for the active phosphorylated receptors.
Henrike Indrischek +4 more
doaj +1 more source
The Viral G Protein-Coupled Receptor ORF74 Hijacks β-Arrestins for Endocytic Trafficking in Response to Human Chemokines. [PDF]
PLoS ONE, 2015 Kaposi's sarcoma-associated herpesvirus-infected cells express the virally encoded G protein-coupled receptor ORF74. Although ORF74 is constitutively active, it binds human CXC chemokines that modulate this basal activity.
Sabrina M de Munnik +7 more
doaj +1 more source
β-Arrestins in the Immune System [PDF]
, 2013 β-Arrestins regulate G protein-coupled receptors through receptor desensitization while also acting as signaling scaffolds to facilitate numerous effector pathways. Recent studies have provided evidence that β-arrestins play a key role in inflammatory responses.
Dianhua, Jiang +3 more
openaire +2 more sources
β-Arrestin-Mediated Signaling Improves the Efficacy of Therapeutics
Journal of Pharmacological Sciences, 2012 β-Arrestins (β-arrestin-1 and β-arrestin-2) were first identified as proteins that have the ability to desensitize G protein-coupled receptors (GPCRs). However, it has recently been found that β-arrestins can activate signaling pathways independent of G ...
Islam A.A.E.-H. Ibrahim, Hitoshi Kurose
doaj +1 more source