Results 31 to 40 of about 7,477 (214)

Reduced expression of G protein-coupled receptor kinases in schizophrenia but not in schizoaffective disorder

Neurobiology of Disease, 2011
Alterations of multiple G protein-mediated signaling pathways are detected in schizophrenia. G protein-coupled receptor kinases (GRKs) and arrestins terminate signaling by G protein-coupled receptors exerting a powerful influence on receptor functions ...
E.R. Bychkov, M.R. Ahmed, V.V. Gurevich, J.L. Benovic, E.V. Gurevich   +4 more
doaj   +1 more source

Ascidian arrestin (Ci‐arr), the origin of the visual and nonvisual arrestins of vertebrate [PDF]

European Journal of Biochemistry, 2002
Arrestin is one of the key proteins for the termination of G protein signaling. Activated G protein‐coupled receptors (GPCRs) are specifically phosphorylated by G protein‐coupled receptor kinases (GRKs) and then bind to arrestins to preclude the receptor/G protein interaction, resulting in quenching of the following signal transduction.
Masashi, Nakagawa, Hidefumi, Orii, Norihiro, Yoshida, Eri, Jojima, Takeo, Horie, Reiko, Yoshida, Tatsuya, Haga, Motoyuki, Tsuda   +7 more
openaire   +2 more sources

Lack of beta-arrestin signaling in the absence of active G proteins

Nature Communications, 2018
Arrestins terminate signaling from GPCRs, but several lines of evidence suggest that they are also able to transduce signals independently of G proteins. Here, the authors systematically ablate G proteins in cell lines, and show that arrestins are unable
Manuel Grundmann, Nicole Merten, Davide Malfacini, Asuka Inoue, Philip Preis, Katharina Simon, Nelly Rüttiger, Nicole Ziegler, Tobias Benkel, Nina Katharina Schmitt, Satoru Ishida, Ines Müller, Raphael Reher, Kouki Kawakami, Ayumi Inoue, Ulrike Rick, Toni Kühl, Diana Imhof, Junken Aoki, Gabriele M. König, Carsten Hoffmann, Jesus Gomeza, Jürgen Wess, Evi Kostenis   +23 more
doaj   +1 more source

Arrestins: structural disorder creates rich functionality

Protein & Cell, 2018
Arrestins are soluble relatively small 44–46 kDa proteins that specifically bind hundreds of active phosphorylated GPCRs and dozens of non-receptor partners.
Vsevolod V. Gurevich, Eugenia V. Gurevich, Vladimir N. Uversky   +2 more
doaj   +1 more source

β-Arrestin regulation of myosin light chain phosphorylation promotes AT1aR-mediated cell contraction and migration. [PDF]

PLoS ONE, 2013
Over the last decade, it has been established that G-protein-coupled receptors (GPCRs) signal not only through canonical G-protein-mediated mechanisms, but also through the ubiquitous cellular scaffolds β-arrestin-1 and β-arrestin-2.
Elie Simard, Jeffrey J Kovacs, William E Miller, Jihee Kim, Michel Grandbois, Robert J Lefkowitz   +5 more
doaj   +1 more source

Discrete GPCR-triggered endocytic modes enable β-arrestins to flexibly regulate cell signaling

eLife, 2022
β-Arrestins are master regulators of cellular signaling that operate by desensitizing ligand-activated G-protein-coupled receptors (GPCRs) at the plasma membrane and promoting their subsequent endocytosis.
Benjamin Barsi-Rhyne, Aashish Manglik, Mark von Zastrow   +2 more
doaj   +1 more source

Structure and functions of arrestins [PDF]

Protein Science, 1994
AbstractTransmembrane signal transductions in a variety of cell types that mediate signals as diverse as those carried by neurotransmitters, hormones, and sensory signals share basic biochemical mechanisms that include: (1) an extracellular perturbation (neurotransmitter, hormone, odor, light); (2) specific receptors; (3) coupling proteins, such as G ...
openaire   +2 more sources

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Accelerated evolution of dim-light vision-related arrestin in deep-diving amniotes

Frontiers in Ecology and Evolution, 2022
Arrestins are key molecules involved in the signaling of light-sensation initiated by visual pigments in retinal photoreceptor cells. Vertebrate photoreceptor cells have two types of arrestins, rod arrestin, which is encoded by SAG and is expressed in ...
Xin Guo, Yimeng Cui, David M. Irwin, Yang Liu   +3 more
doaj   +1 more source

Untangling Inositol (Pyro)Phosphate Biology Through Emerging Technologies

Advanced Science, EarlyView.
Inositol (pyro)phosphates represent a vital class of intracellular messengers that govern multiple biological processes. The last decade has experienced a surge of interest in the functions of this class of signaling molecules, primarily due to the introduction of several innovative analytical technologies.
Adolfo Saiardi, Mengsi Lu, Yue Zhang, Anuj Shukla, An‐Li Andrea Ko, Henning J. Jessen   +5 more
wiley   +1 more source