Results 31 to 40 of about 9,354 (195)

Ubiquitin-Mediated Regulation of Endocytosis by Proteins of the Arrestin Family

Biochemistry Research International, 2012
In metazoans, proteins of the arrestin family are key players of G-protein-coupled receptors (GPCRS) signaling and trafficking. Following stimulation, activated receptors are phosphorylated, thus allowing the binding of arrestins and hence an “arrest” of
Michel Becuwe, Antonio Herrador, Rosine Haguenauer-Tsapis, Olivier Vincent, Sébastien Léon   +4 more
doaj   +1 more source

β-Arrestin-dependent and -independent endosomal G protein activation by the vasopressin type 2 receptor

eLife, 2023
The vasopressin type 2 receptor (V2R) is an essential G protein-coupled receptor (GPCR) in renal regulation of water homeostasis. Upon stimulation, the V2R activates Gαs and Gαq/11, which is followed by robust recruitment of β-arrestins and receptor ...
Carole Daly, Akim Abdul Guseinov, Hyunggu Hahn, Adam Wright, Irina G Tikhonova, Alex Rojas Bie Thomsen, Bianca Plouffe   +6 more
doaj   +1 more source

Distinct G protein-coupled receptor phosphorylation motifs modulate arrestin affinity and activation and global conformation

Nature Communications, 2019
The cellular functions of arrestins are determined in part by the pattern of phosphorylation on the G protein-coupled receptors (GPCRs) to which arrestins bind.
Daniel Mayer, Fred F. Damberger, Mamidi Samarasimhareddy, Miki Feldmueller, Ziva Vuckovic, Tilman Flock, Brian Bauer, Eshita Mutt, Franziska Zosel, Frédéric H. T. Allain, Jörg Standfuss, Gebhard F. X. Schertler, Xavier Deupi, Martha E. Sommer, Mattan Hurevich, Assaf Friedler, Dmitry B. Veprintsev   +16 more
doaj   +1 more source

Reduced expression of G protein-coupled receptor kinases in schizophrenia but not in schizoaffective disorder

Neurobiology of Disease, 2011
Alterations of multiple G protein-mediated signaling pathways are detected in schizophrenia. G protein-coupled receptor kinases (GRKs) and arrestins terminate signaling by G protein-coupled receptors exerting a powerful influence on receptor functions ...
E.R. Bychkov, M.R. Ahmed, V.V. Gurevich, J.L. Benovic, E.V. Gurevich   +4 more
doaj   +1 more source

Quantification of beta adrenergic receptor subtypes in beta-arrestin knockout mouse airways. [PDF]

PLoS ONE, 2015
In allergic asthma Beta 2 adrenergic receptors (β2ARs) are important mediators of bronchorelaxation and, paradoxically, asthma development. This contradiction is likely due to the activation of dual signaling pathways that are downstream of G proteins or
Akhil Hegde, Ryan T Strachan, Julia K L Walker   +2 more
doaj   +1 more source

Differential Involvement of ACKR3 C-Tail in β-Arrestin Recruitment, Trafficking and Internalization

Cells, 2021
Background: The atypical chemokine receptor 3 (ACKR3) belongs to the superfamily of G protein-coupled receptors (GPCRs). Unlike classical GPCRs, this receptor does not activate G proteins in most cell types but recruits β-arrestins upon activation. ACKR3
Aurélien Zarca, Claudia Perez, Jelle van den Bor, Jan Paul Bebelman, Joyce Heuninck, Rianna J. F. de Jonker, Thierry Durroux, Henry F. Vischer, Marco Siderius, Martine J. Smit   +9 more
doaj   +1 more source

To Be Biased or Not to Be: A Play for G-Protein Coupled Receptors

International Journal of Translational Medicine
G protein-coupled receptors (GPCRs) are the largest family of diverse receptors in eukaryotic organisms, playing a critical role in modulating human physiology. It therefore comes as no surprise that about 36% of all currently available drugs target this
Nikitas G. Liolitsas, Evangelia Pantazaka, Evangelia Papadimitriou   +2 more
doaj   +1 more source

α-Arrestins Aly1 and Aly2 Regulate Intracellular Trafficking in Response to Nutrient Signaling

, 2010
Extracellular signals regulate trafficking events to reorganize proteins at the plasma membrane (PM); however, few effectors of this regulation have been identified.
Martha S. Cyert, Richard G. Gardner, Allyson F. O'Donnell, Alex Apffel   +3 more
core   +1 more source

Ascidian arrestin (Ci‐arr), the origin of the visual and nonvisual arrestins of vertebrate [PDF]

European Journal of Biochemistry, 2002
Arrestin is one of the key proteins for the termination of G protein signaling. Activated G protein‐coupled receptors (GPCRs) are specifically phosphorylated by G protein‐coupled receptor kinases (GRKs) and then bind to arrestins to preclude the receptor/G protein interaction, resulting in quenching of the following signal transduction.
Masashi, Nakagawa, Hidefumi, Orii, Norihiro, Yoshida, Eri, Jojima, Takeo, Horie, Reiko, Yoshida, Tatsuya, Haga, Motoyuki, Tsuda   +7 more
openaire   +2 more sources

Agonist-dependent internalization of the angiotensin II type one receptor (AT1): role of C-terminus phosphorylation in recruitment of β-arrestins

, 2004
β-Arrestins play a role in AT1 endocytosis by binding the cytoplasmic, C-terminus region T332–S338, the major site of angiotensin II (Ang II)-induced phosphorylation.
Baker, Kenneth M., Booz, George W., Dinh, Diem, Karoor, Vijaya, Kule, Chris E., Day, Jonathan N. E., Acker, Kathleen A., Thomas, Walter G.   +7 more
core   +1 more source