c-Src regulates Akt signaling in response to ghrelin via beta-arrestin signaling-independent and -dependent mechanisms. [PDF]
PLoS ONE, 2009 The aim of the present study was to identify the signaling mechanisms to ghrelin-stimulated activation of the serine/threonine kinase Akt. In human embryonic kidney 293 (HEK293) cells transfected with GHS-R1a, ghrelin leads to the activation of Akt ...
Maria Lodeiro +4 more
doaj +3 more sources
On the origins of arrestin and rhodopsin [PDF]
BMC Evolutionary Biology, 2008 Background G protein coupled receptors (GPCRs) are the most numerous proteins in mammalian genomes, and the most common targets of clinical drugs. However, their evolution remains enigmatic.
Alvarez Carlos E
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Mammalian α arrestins link activated seven transmembrane receptors to Nedd4 family e3 ubiquitin ligases and interact with β arrestins. [PDF]
PLoS ONE, 2012 The complement of fungal cell surface proteins is widely regulated by ubiquitination of membrane proteins, which results in their endocytosis and vacuolar degradation.
Fortune F Shea +4 more
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Distinct and shared roles of β-arrestin-1 and β-arrestin-2 on the regulation of C3a receptor signaling in human mast cells. [PDF]
PLoS ONE, 2011 The complement component C3a induces degranulation in human mast cells via the activation of cell surface G protein coupled receptors (GPCR; C3aR).
Arpana Vibhuti +4 more
doaj +3 more sources
Arrestins: structural disorder creates rich functionality
Protein & Cell, 2018 Arrestins are soluble relatively small 44–46 kDa proteins that specifically bind hundreds of active phosphorylated GPCRs and dozens of non-receptor partners.
Vsevolod V. Gurevich +2 more
doaj +2 more sources
True Arrestins and Arrestin-Fold Proteins
, 2013 International audienceArrestin-clan proteins are folded alike, a feature responsible for their recent grouping in a single clan. In human, it includes the well-characterized visual and β-arrestins, the arrestin domain-containing proteins (ARRDCs ...
Laurence Aubry, Gérard Klein
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Regulation of cardiac fibroblast-mediated maladaptive ventricular remodeling by β-arrestins.
PLoS ONE, 2019 Cardiac fibroblasts (CF) play a critical role in post-infarction remodeling which can ultimately lead to pathological fibrosis and heart failure.
Jennifer L Philip +4 more
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Arrestin development: a role for β-arrestins in viral myocarditis. [PDF]
Am J Physiol Heart Circ PhysiolDasgupta S +2 more
europepmc +3 more sources
, 2016 The growth hormone secretagogue receptor, GHSR1a, mediates the biological activities of ghrelin, which includes the secretion of growth hormone, as well as the stimulation of appetite, food intake and maintenance of energy homeostasis.
R. Nogueiras (7691495) +9 more
core +7 more sources
The arrestin superfamily: cone arrestins are a fourth family [PDF]
FEBS Letters, 1995 Arrestins constitute a superfamily of regulatory proteins that down‐regulate phosphorylated G‐protein membrane receptors, including rod and cone photoreceptors and adrenergic receptors. The potential role of arrestin in color visual processes led us to identify a cDNA encoding a cone‐like arrestin in Xenopus laevis, the principle amphibian biological ...
Craft, Cheryl M., Whitmore, Donald H.
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