, 2013 Programmed cell death (apoptosis) is a coordinated set of events eventually leading to the massive activation of specialized proteases (caspases) that cleave numerous substrates, orchestrating fairly uniform biochemical changes than culminate in cellular suicide. Apoptosis can be triggered by a variety of stimuli, from external signals or growth factor
Seunghyi, Kook +2 more
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Heterologous phosphorylation–induced formation of a stability lock permits regulation of inactive receptors by beta-arrestins [PDF]
, 2018 -Arrestins are key regulators and signal transducers of G protein– coupled receptors (GPCRs). The interaction between receptors and -arrestins is generally believed to require both receptor activity and phosphorylation by GPCR kinases.
Pál Gyombolai +16 more
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Desensitization, internalization, and signaling functions of beta-arrestins demonstrated by RNA interference. [PDF]
, 2003 Beta-arrestins bind to activated G protein-coupled receptor kinase-phosphorylated receptors, which leads to their desensitization with respect to G proteins, internalization via clathrin-coated pits, and signaling via a growing list of "scaffolded ...
Garrison, Tiffany Runyan +4 more
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, 2015 Arrestins specifically bind active phosphorylated G protein-coupled receptors (GPCRs). Receptor binding induces the release of the arrestin C-tail, which in non-visual arrestins contains high-affinity binding sites for clathrin and its adaptor AP2. Thus, serving as a physical link between the receptor and key components of the internalization machinery
Vsevolod V, Gurevich +1 more
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X‐Arrestin: a new retinal arrestin mapping to the X chromosome [PDF]
FEBS Letters, 1993 We have been using a differential cDNA cloning approach to isolate human retina‐specific and retina‐enriched genes [1]. A 1,314 bp cDNA was isolated by this approach, representing a highly retina‐specific message encoding a 388 amino acid protein showing 58%, 50%, and 49% homology to bovine β‐arrestin, and bovine and human retinal arrestin (S‐antigen),
Murakami, Akira +4 more
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Differential Regulation of GPCRs—Are GRK Expression Levels the Key?
Frontiers in Cell and Developmental Biology, 2021 G protein-coupled receptors (GPCRs) comprise the largest family of transmembrane receptors and their signal transduction is tightly regulated by GPCR kinases (GRKs) and β-arrestins.
Edda S. F. Matthees +3 more
doaj +1 more source
Distinct cellular and subcellular distributions of G protein-coupled receptor kinase and arrestin isoforms in the striatum. [PDF]
PLoS ONE, 2012 G protein-coupled receptor kinases (GRKs) and arrestins mediate desensitization of G protein-coupled receptors (GPCR). Arrestins also mediate G protein-independent signaling via GPCRs.
Evgeny Bychkov +4 more
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Multiple Scaffolding Functions of β-Arrestins in the Degradation of G Protein-coupled Receptor Kinase 2 [PDF]
, 2011 G protein-coupled receptor kinase 2 (GRK2) plays a fundamental role in the regulation of G protein-coupled receptors (GPCRs), and changes in GRK2 expression levels can have an important impact on cell functions.
Federico Mayor +9 more
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Regulation of the Cardiac Potassium Channel Kir2.1 by the alpha-arrestins
, 2020 1. Kir2.1 is a mammalian potassium channel that is linked to numerous cardiac arrhythmias when it is unable to function or be trafficked correctly. 2.
Ceara K. McAtee (8729687) +5 more
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Endothelin-converting enzyme-1 regulates endosomal sorting of calcitonin receptor-like receptor and beta-arrestins [PDF]
, 2007 Although cell surface metalloendopeptidases degrade neuropeptides in the extracellular fluid to terminate signaling, the function of peptidases in endosomes is unclear.
Muller, Laurent +27 more
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