Results 1 to 10 of about 35,154 (135)
Cell-based and isoform-selective G protein-coupled receptor kinase assays for comprehensive inhibitor evaluation [PDF]
Communications BiologyG protein-coupled receptor (GPCR) signaling is regulated by four ubiquitously expressed GPCR kinase isoforms (GRKs), namely GRK2, GRK3, GRK5, and GRK6. Overexpression of individual GRKs occurs in diseases like cancer and heart failure, prompting a search
Nina K. Blum +11 more
doaj +2 more sources
Differential Regulation of GPCRs—Are GRK Expression Levels the Key?
Frontiers in Cell and Developmental Biology, 2021 G protein-coupled receptors (GPCRs) comprise the largest family of transmembrane receptors and their signal transduction is tightly regulated by GPCR kinases (GRKs) and β-arrestins.
Carsten Hoffmann, Julia Drube
exaly +3 more sources
Intracellular and Extracellular Roles of Granzyme K
Frontiers in Immunology, 2021 Granzymes are a family of serine proteases stored in granules inside cytotoxic cells of the immune system. Granzyme K (GrK) has been only limitedly characterized and knowledge on its molecular functions is emerging.
Annemieke C. Bouwman +5 more
doaj +1 more source
Journal of Natural Resources and Environmental Management, 2021 Pertumbuhan perkebunan kelapa sawit di Indonesia mengalami peningkatan yang cukup pesat. Dampak negatif yang ditimbulkan akibat pertumbuhan perkebunan kelapa sawit ini adalah kerusakan lingkungan dan peningkatan emisi gas rumah kaca (GRK). Penelitian ini
Danang Harimurti
doaj +1 more source
Granzyme K activates protease-activated receptor-1. [PDF]
PLoS ONE, 2011 Granzyme K (GrK) is a trypsin-like serine protease that is elevated in patients with sepsis and acute lung inflammation. While GrK was originally believed to function exclusively as a pro-apoptotic protease, recent studies now suggest that GrK may ...
Dawn M Cooper +4 more
doaj +1 more source
Frontiers in Oncology, 2021 Angiogenesis is crucial for normal development and homeostasis, but also plays a role in many diseases including cardiovascular diseases, autoimmune diseases, and cancer.
Shuang Li +12 more
doaj +1 more source
Metode Pembelajaran Mesin untuk Memprediksi Emisi Manure Management
Jurnal Nasional Teknik Elektro dan Teknologi Informasi, 2022 Indonesia berkomitmen menurunkan emisi gas rumah kaca (GRK) melalui skema nationally determined contribution (NDC). Target yang hendak dicapai untuk menurunkan emisi GRK yaitu 29% melalui skema business as usual (BAU) atau 41% dengan bantuan ...
Widi Hastomo +3 more
doaj +1 more source
Distinct Phosphorylation Patterns of AT1R by Biased Ligands and GRK Subtypes [PDF]
International Journal of Molecular SciencesJingyuan Li, Haitao Zhang
exaly +2 more sources
Photocatalytic Isomerization of (E)-Anethole to (Z)-Anethole
Molecules, 2022 Natural product (E)-anethole was isomerized to (Z)-anethole in a photocatalytic reaction. For this purpose, a self-designed cheap photoreactor was constructed.
Marvin Korff +4 more
doaj +1 more source
GRK Inhibition Potentiates Glucagon-Like Peptide-1 Action
Frontiers in Endocrinology, 2021 The glucagon-like peptide-1 receptor (GLP-1R) is a G-protein-coupled receptor (GPCR) whose activation results in suppression of food intake and improvement of glucose metabolism. Several receptor interacting proteins regulate the signaling of GLP-1R such
Seunghun P. Lee +7 more
doaj +1 more source