Results 11 to 20 of about 35,270 (239)
GRKs as Modulators of Neurotransmitter Receptors [PDF]
Cells, 2020 Many receptors for neurotransmitters, such as dopamine, norepinephrine, acetylcholine, and neuropeptides, belong to the superfamily of G protein-coupled receptors (GPCRs). A general model posits that GPCRs undergo two-step homologous desensitization: the
Eugenia V. Gurevich +1 more
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Suitability of GRK Antibodies for Individual Detection and Quantification of GRK Isoforms in Western Blots [PDF]
International Journal of Molecular Sciences, 2021 G protein-coupled receptors (GPCRs) are regulated by GPCR kinases (GRKs) which phosphorylate intracellular domains of the active receptor. This results in the recruitment of arrestins, leading to desensitization and internalization of the GPCR. Aside from acting on GPCRs, GRKs regulate a variety of membrane, cytosolic, and nuclear proteins not only via
Mona Reichel +4 more
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The Roles of GRKs in Hemostasis and Thrombosis [PDF]
International Journal of Molecular Sciences, 2020 Along with cancer, cardiovascular and cerebrovascular diseases remain by far the most common causes of death. Heart attacks and strokes are diseases in which platelets play a role, through activation on ruptured plaques and subsequent thrombus formation. Most platelet agonists activate platelets via G protein-coupled receptors (GPCRs), which make these
Xi Chen +3 more
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The GRKs Reactome: Role in Cell Biology and Pathology [PDF]
International Journal of Molecular Sciences, 2021 G protein-coupled receptor kinases (GRKs) are protein kinases that function in concert with arrestins in the regulation of a diverse class of G protein-coupled receptors (GPCRs) signaling. Although GRKs and arrestins are key participants in the regulation of GPCR cascades, the complex regulatory mechanisms of GRK expression, its alternation, and their ...
Chaudhary, Preeti Kumari, Kim, Soochong
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Dinamika Rekayasa, 2022 Pemetaan potensi energi terbarukan penting dilakukan untuk mengetahui potensi energi terbarukan dan potensi reduksi emisi gas rumah kaca (GRK) desa belum berlistrik di Provinsi Papua Barat yang berjumlah 29 desa.
Elias Kondorura Bawan +1 more
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Biomolecules, 2023 The D2 dopamine receptor (D2R) signals through both G proteins and β-arrestins to regulate important physiological processes, such as movement, reward circuitry, emotion, and cognition.
Marta Sánchez-Soto +12 more
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GRKs and Epac1 Interaction in Cardiac Remodeling and Heart Failure [PDF]
Cells, 2021 β-adrenergic receptors (β-ARs) play a major role in the physiological regulation of cardiac function through signaling routes tightly controlled by G protein-coupled receptor kinases (GRKs). Although the acute stimulation of β-ARs and the subsequent production of cyclic AMP (cAMP) have beneficial effects on cardiac function, chronic stimulation of β ...
Lezoualc'H, Frank +2 more
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PLoS Genetics, 2023 Animals alter their behavior in manners that depend on environmental conditions as well as their developmental and metabolic states. For example, C. elegans is quiescent during larval molts or during conditions of satiety.
Kristen Davis +6 more
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