Results 11 to 20 of about 4,151 (197)
Differential Regulation of GPCRs—Are GRK Expression Levels the Key? [PDF]
Frontiers in Cell and Developmental Biology, 2021 G protein-coupled receptors (GPCRs) comprise the largest family of transmembrane receptors and their signal transduction is tightly regulated by GPCR kinases (GRKs) and β-arrestins.
Edda S. F. Matthees +3 more
doaj +5 more sources
GRKs as Modulators of Neurotransmitter Receptors [PDF]
Cells, 2020 Many receptors for neurotransmitters, such as dopamine, norepinephrine, acetylcholine, and neuropeptides, belong to the superfamily of G protein-coupled receptors (GPCRs). A general model posits that GPCRs undergo two-step homologous desensitization: the
Eugenia V. Gurevich +1 more
doaj +3 more sources
GRK et arrestines : la piste thérapeutique ? [PDF]
médecine/sciences, 2006 La phosphorylation d’un recepteur couple aux proteines G (RCPG) par une kinase specifique, nommee GRK (G protein-coupled receptor kinase), est une premiere etape qui participe, avec l’action des arrestines, a l’arret de la transmission du signal, au cours d’un processus appele desensibilisation.
Métayé, Thierry +2 more
openaire +4 more sources
Quantitative Modeling of GRK-Mediated β2AR Regulation
PLoS Computational Biology, 2010 We developed a unified model of the GRK-mediated beta2 adrenergic receptor (beta2AR) regulation that simultaneously accounts for six different biochemical measurements of the system obtained over a wide range of agonist concentrations. Using a single deterministic model we accounted for (1) GRK phosphorylation in response to various full and partial ...
Sharat J. Vayttaden +5 more
openaire +5 more sources
Suitability of GRK Antibodies for Individual Detection and Quantification of GRK Isoforms in Western Blots [PDF]
International Journal of Molecular Sciences, 2021 G protein-coupled receptors (GPCRs) are regulated by GPCR kinases (GRKs) which phosphorylate intracellular domains of the active receptor. This results in the recruitment of arrestins, leading to desensitization and internalization of the GPCR. Aside from acting on GPCRs, GRKs regulate a variety of membrane, cytosolic, and nuclear proteins not only via
Mona Reichel +4 more
openaire +3 more sources
The Roles of GRKs in Hemostasis and Thrombosis [PDF]
International Journal of Molecular Sciences, 2020 Along with cancer, cardiovascular and cerebrovascular diseases remain by far the most common causes of death. Heart attacks and strokes are diseases in which platelets play a role, through activation on ruptured plaques and subsequent thrombus formation. Most platelet agonists activate platelets via G protein-coupled receptors (GPCRs), which make these
Xi Chen +3 more
openaire +2 more sources
The GRKs Reactome: Role in Cell Biology and Pathology [PDF]
International Journal of Molecular Sciences, 2021 G protein-coupled receptor kinases (GRKs) are protein kinases that function in concert with arrestins in the regulation of a diverse class of G protein-coupled receptors (GPCRs) signaling. Although GRKs and arrestins are key participants in the regulation of GPCR cascades, the complex regulatory mechanisms of GRK expression, its alternation, and their ...
Chaudhary, Preeti Kumari, Kim, Soochong
openaire +2 more sources
Hepatology, EarlyView., 2022 Hepatic endothelial Alk1 signaling protects from development of vascular malformations while maintaining organ‐specific endothelial differentiation and angiocrine portmanteau of the names Wingless and Int‐1 signaling. Abstract Background and Aims In hereditary hemorrhagic telangiectasia (HHT), severe liver vascular malformations are associated with ...
Christian David Schmid +20 more
wiley +1 more source