Results 21 to 30 of about 4,151 (197)
GRKs and Epac1 Interaction in Cardiac Remodeling and Heart Failure [PDF]
Cells, 2021 β-adrenergic receptors (β-ARs) play a major role in the physiological regulation of cardiac function through signaling routes tightly controlled by G protein-coupled receptor kinases (GRKs). Although the acute stimulation of β-ARs and the subsequent production of cyclic AMP (cAMP) have beneficial effects on cardiac function, chronic stimulation of β ...
Lezoualc'H, Frank +2 more
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Biomolecules, 2023 The D2 dopamine receptor (D2R) signals through both G proteins and β-arrestins to regulate important physiological processes, such as movement, reward circuitry, emotion, and cognition.
Marta Sánchez-Soto +12 more
doaj +1 more source
Rational Cohomology Algebra of Mapping Spaces between Complex Grassmannians
International Journal of Mathematics and Mathematical Sciences, 2020 We consider the complex Grassmannian Grk,n of k-dimensional subspaces of ℂn. There is a natural inclusion in,r:Grk,n↪Grk,n+r. Here, we use Sullivan models to compute the rational cohomology algebra of the component of the inclusion in,r in the space of ...
Paul Antony Otieno +2 more
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Fantastische Technik im Mittelalter? Zu (Glücks-)Rädern in zwei mittelhochdeutschen Artusromanen
Zeitschrift für Fantastikforschung, 2020 Recent works in the field of German medieval literature argue that the category of ›the fantastic‹ needs to be defined in demarcation to the medieval category of ›the marvelous‹, and, thus, the focus of text analyses should lay on forms and functions of ›
Hanna Myriam Häger
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Intravesical Bladder Treatment and Deep Learning Applications to Improve Irritative Voiding Symptoms Caused by Interstitial Cystitis: A Literature Review [PDF]
International Neurourology Journal, 2023 Our comprehension of interstitial cystitis/painful bladder syndrome (IC/PBS) has evolved over time. The term painful bladder syndrome, preferred by the International Continence Society, is characterized as “a syndrome marked by suprapubic pain during ...
Yongwon Cho, Seunghyun Youn
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GRKs and arrestins: regulators of migration and inflammation [PDF]
Journal of Leukocyte Biology, 2006 AbstractIn the immune system, signaling by G protein-coupled receptors (GPCRs) is crucial for the activity of multiple mediators, including chemokines, leukotrienes, and neurotransmitters. GPCR kinases (GRKs) and arrestins control GPCR signaling by mediating desensitization and thus, regulating further signal propagation through G proteins.
Anne, Vroon +2 more
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Frontiers in Immunology, 2022 G-protein coupled receptor kinases (GRKs) participate in the regulation of chemokine receptors by mediating receptor desensitization. They can be recruited to agonist-activated G-protein coupled receptors (GPCRs) and phosphorylate their intracellular ...
Katharina M. Glaser +4 more
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The Structure of G Protein-coupled Receptor Kinase (GRK)-6 Defines a Second Lineage of GRKs [PDF]
Journal of Biological Chemistry, 2006 We describe the 2.6-A crystal structure of human G protein-coupled receptor kinase (GRK)-6, a key regulator of dopaminergic signaling and lymphocyte chemotaxis. GRK6 is a member of the GRK4 subfamily of GRKs, which is represented in most, if not all, metazoans.
David T, Lodowski +3 more
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Relative Gottlieb Groups of Embeddings between Complex Grassmannians
International Journal of Mathematics and Mathematical Sciences, 2021 Let Grk,n be the complex Grassmann manifold of k-linear subspaces in ℂn. We compute rational relative Gottlieb groups of the embedding i:Grk,n⟶Grk,n+r and show that the G-sequence is exact if r≥kn−k.
J. B. Gatsinzi
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GRKs as Key Modulators of Opioid Receptor Function [PDF]
Cells, 2020 Understanding the link between agonist-induced phosphorylation of the mu-opioid receptor (MOR) and the associated physiological effects is critical for the development of novel analgesic drugs and is particularly important for understanding the mechanisms responsible for opioid-induced tolerance and addiction.
Laura Lemel +2 more
openaire +3 more sources