Results 11 to 20 of about 46,183 (248)

Receptor-Arrestin Interactions: The GPCR Perspective

Biomolecules, 2021
Arrestins are a small family of four proteins in most vertebrates that bind hundreds of different G protein-coupled receptors (GPCRs). Arrestin binding to a GPCR has at least three functions: precluding further receptor coupling to G proteins ...
Mohammad Seyedabadi, Eugenia V Gurevich, Vsevolod V Gurevich   +2 more
exaly   +3 more sources

Distinct membrane binding properties of the two non-visual arrestins [PDF]

Communications Biology
Membrane interactions play a crucial role in regulating arrestin activation and its binding to phosphorylated G protein-coupled receptors (GPCRs).
Thomas D. Killeen, Katelyn Tepper, Kyle W. Miller, Yasmin Aydin, Ya Zhuo, Shuaitong Zhao, Jason M. Conley, Rachel Tat, Candice S. Klug, Adriano Marchese, Valerică Raicu, Qiuyan Chen   +11 more
doaj   +2 more sources

Signaling bias of the protease-activated receptor-1 is dictated by distinct GRK5 and β-arrestin-2 determinants [PDF]

Cell Reports
Summary: G protein-coupled receptors (GPCRs) exhibit signaling bias or preferential activation of heterotrimeric G proteins versus GPCR kinase (GRK)-mediated β-arrestin signaling.
Monica L. Gonzalez Ramirez, Lennis B. Orduña-Castillo, Carolyne Bardeleben, Huaping Qin, Ying Lin, Cierra A. Birch, Irina Kufareva, JoAnn Trejo   +7 more
doaj   +2 more sources

Arrestin development: a role for β-arrestins in viral myocarditis. [PDF]

Am J Physiol Heart Circ Physiol
Dasgupta S, Dempster T, DeLeon-Pennell KY.   +2 more
europepmc   +3 more sources

The β-blocker Nebivolol Is a GRK/β-arrestin Biased Agonist [PDF]

, 2013
Nebivolol, a third generation β-adrenoceptor (β-AR) antagonist (β-blocker), causes vasodilation by inducing nitric oxide (NO) production. The mechanism via which nebivolol induces NO production remains unknown, resulting in the genesis of much of the ...
Andresen, Bradley T., Bastepe, Murat, Blessing, Christopher P., Erickson, Catherine E., Gul, Rukhsana, Holowka, David, Jackson, Edwin K., Liu, Tammy, Nguyen, Jenny, Pulakat, Lakshmi   +9 more
core   +14 more sources

β-arrestin-1 and β-arrestin-2 Restrain MRGPRX2-Triggered Degranulation and ERK1/2 Activation in Human Skin Mast Cells

Frontiers in Allergy, 2022
As a novel receptor that efficiently elicits degranulation upon binding to one of its numerous ligands, MRGPRX2 has moved to the center of attention in mast cell (MC) research.
Zhao Wang, Zhao Wang, Zhao Wang, Zhuoran Li, Zhuoran Li, Gürkan Bal, Gürkan Bal, Kristin Franke, Kristin Franke, Torsten Zuberbier, Torsten Zuberbier, Magda Babina, Magda Babina   +12 more
doaj   +1 more source

ClickArr: a novel, high-throughput assay for evaluating β-arrestin isoform recruitment

Frontiers in Pharmacology, 2023
Background: Modern methods for quantifying signaling bias at G protein–coupled receptors (GPCRs) rely on using a single β-arrestin isoform. However, it is increasingly appreciated that the two β-arrestin isoforms have unique roles, requiring the ability ...
Alexander R. French, Alexander R. French, Yazan J. Meqbil, Yazan J. Meqbil, Richard M. van Rijn, Richard M. van Rijn, Richard M. van Rijn   +6 more
doaj   +1 more source

The arrestin superfamily: cone arrestins are a fourth family [PDF]

FEBS Letters, 1995
Arrestins constitute a superfamily of regulatory proteins that down‐regulate phosphorylated G‐protein membrane receptors, including rod and cone photoreceptors and adrenergic receptors. The potential role of arrestin in color visual processes led us to identify a cDNA encoding a cone‐like arrestin in Xenopus laevis, the principle amphibian biological ...
Craft, Cheryl M., Whitmore, Donald H.
openaire   +2 more sources

Exploration of beta-arrestin isoform signaling pathways in delta opioid receptor agonist-induced convulsions

Frontiers in Pharmacology, 2022
The δ-opioid receptor (δOR) has been considered as a therapeutic target in multiple neurological and neuropsychiatric disorders particularly as δOR agonists are deemed safer alternatives relative to the more abuse-liable µ-opioid receptor drugs. Clinical
Arryn T. Blaine, Arryn T. Blaine, Yiming Miao, Jinling Yuan, Sophia Palant, Rebecca J. Liu, Zhong-Yin Zhang, Zhong-Yin Zhang, Zhong-Yin Zhang, Richard. M. van Rijn, Richard. M. van Rijn, Richard. M. van Rijn, Richard. M. van Rijn   +12 more
doaj   +1 more source

CXCR7 controls competition for recruitment of β-arrestin 2 in cells expressing both CXCR4 and CXCR7. [PDF]

PLoS ONE, 2014
Chemokine CXCL12 promotes growth and metastasis of more than 20 different human cancers, as well as pathogenesis of other common diseases. CXCL12 binds two different receptors, CXCR4 and CXCR7, both of which recruit and signal through the cytosolic ...
Nathaniel L Coggins, Danielle Trakimas, S Laura Chang, Anna Ehrlich, Paramita Ray, Kathryn E Luker, Jennifer J Linderman, Gary D Luker   +7 more
doaj   +1 more source