Results 21 to 30 of about 18,493 (159)
B-arrestin-2 Signaling Is Important to Preserve Cardiac Function During Aging
Frontiers in Physiology, 2021 Experiments reported here tested the hypothesis that β-arrestin-2 is an important element in the preservation of cardiac function during aging. We tested this hypothesis by aging β-arrestin-2 knock-out (KO) mice, and wild-type equivalent (WT) to 12 ...
Andrielle E. Capote +7 more
doaj +1 more source
β-Arrestin-dependent deactivation of mouse melanopsin.
PLoS ONE, 2014 In mammals, the expression of the unusual visual pigment, melanopsin, is restricted to a small subset of intrinsically photosensitive retinal ganglion cells (ipRGCs), whose signaling regulate numerous non-visual functions including sleep, circadian ...
Evan G Cameron, Phyllis R Robinson
doaj +1 more source
Surfactant protein-A modulates LPS-induced TLR4 localization and signaling via β-arrestin 2. [PDF]
PLoS ONE, 2013 The soluble C-type lectin surfactant protein (SP)-A mediates lung immune responses partially via its direct effects on alveolar macrophages (AM), the main resident leukocytes exposed to antigens. SP-A modulates the AM threshold of lipopolysaccharide (LPS)
Vicky Sender, Linda Lang, Cordula Stamme
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Differential Involvement of ACKR3 C-Tail in β-Arrestin Recruitment, Trafficking and Internalization
Cells, 2021 Background: The atypical chemokine receptor 3 (ACKR3) belongs to the superfamily of G protein-coupled receptors (GPCRs). Unlike classical GPCRs, this receptor does not activate G proteins in most cell types but recruits β-arrestins upon activation. ACKR3
Aurélien Zarca +9 more
doaj +1 more source
The Effects of Apelin and Elabela Ligands on Apelin Receptor Distinct Signaling Profiles
Frontiers in Pharmacology, 2021 Apelin and Elabela are endogenous peptide ligands for Apelin receptor (APJ), a widely expressed G protein-coupled receptor. They constitute a spatiotemporal dual ligand system to control APJ signal transduction and function.
Yunlu Jiang +11 more
doaj +1 more source
β-Arrestin1 and 2 differentially regulate PACAP-induced PAC1 receptor signaling and trafficking. [PDF]
PLoS ONE, 2018 A pituitary adenylate cyclase-activating polypeptide (PACAP)-specific receptor, PAC1R, is coupled with multiple signal transduction pathways including stimulation of adenylate cyclase, phospholipase C and extracellular-signal regulated kinase (ERK)1/2 ...
Yusuke Shintani +8 more
doaj +1 more source
Arrestin-biased AT1R agonism induces acute catecholamine secretion through TRPC3 coupling
Nature Communications, 2017 Angiotensin II type 1 receptor (AT1R)-mediated acute catecholamine release is modulated by β-arrestin. Here the authors show that β-arrestin-1 recruits the Ca2+channel TRPC3 and the PLCγ to the AT1R-β-arrestin complex, triggering G protein-independent ...
Chun-Hua Liu +26 more
doaj +1 more source
Journal of Pharmacological Sciences, 2013 .: β-Arrestin-biased agonists are a new class of drugs with promising therapeutic effects. The molecular mechanisms of β-arrestin-biased agonists are still not completely identified.
Islam A.A.E-H. Ibrahim +2 more
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β-Arrestin-1 expression and epithelial-to-mesenchymal transition in laryngeal carcinoma
The International Journal of Biological Markers, 2019 Aim: The novel primary end-point of the present study was to ascertain β-arrestin-1 expression in a cohort of consecutive patients with laryngeal squamous cell carcinoma (LSCC) with information available on their cigarette-smoking habits. A secondary end-
Gino Marioni +10 more
doaj +1 more source
Advanced Science, EarlyView.We report a new thiolate‐reactive α,α‐gem‐dibromo lactam warhead that activates transcription factor Nrf2 and demonstrates anti‐inflammatory activities, which have implications in cancer, neurodegeneration, and cardiovascular diseases. RNA‐seq illuminated detailed transcriptional profiles, and chemical reactions with cysteine‐containing compounds ...
Beau R. Brummel +16 more
wiley +1 more source