Results 11 to 20 of about 18,493 (159)

Prognostic value of β-Arrestins in combination with glucocorticoid receptor in epithelial ovarian cancer

Frontiers in Oncology, 2023
Hormones may be key factors driving cancer development, and epidemiological findings suggest that steroid hormones play a crucial role in ovarian tumorigenesis.
Ji-Won Ryu, Ha-Yeon Shin, Hyo-Sun Kim, Gwan Hee Han, Jeong Won Kim, Hae-Nam Lee, Hanbyoul Cho, Hanbyoul Cho, Hanbyoul Cho, Joon-Yong Chung, Jae-Hoon Kim, Jae-Hoon Kim, Jae-Hoon Kim   +12 more
doaj   +1 more source

Distinct and shared roles of β-arrestin-1 and β-arrestin-2 on the regulation of C3a receptor signaling in human mast cells. [PDF]

PLoS ONE, 2011
The complement component C3a induces degranulation in human mast cells via the activation of cell surface G protein coupled receptors (GPCR; C3aR).
Arpana Vibhuti, Kshitij Gupta, Hariharan Subramanian, Qiang Guo, Hydar Ali   +4 more
doaj   +1 more source

β-Arrestin regulation of myosin light chain phosphorylation promotes AT1aR-mediated cell contraction and migration. [PDF]

PLoS ONE, 2013
Over the last decade, it has been established that G-protein-coupled receptors (GPCRs) signal not only through canonical G-protein-mediated mechanisms, but also through the ubiquitous cellular scaffolds β-arrestin-1 and β-arrestin-2.
Elie Simard, Jeffrey J Kovacs, William E Miller, Jihee Kim, Michel Grandbois, Robert J Lefkowitz   +5 more
doaj   +1 more source

Quantification of beta adrenergic receptor subtypes in beta-arrestin knockout mouse airways. [PDF]

PLoS ONE, 2015
In allergic asthma Beta 2 adrenergic receptors (β2ARs) are important mediators of bronchorelaxation and, paradoxically, asthma development. This contradiction is likely due to the activation of dual signaling pathways that are downstream of G proteins or
Akhil Hegde, Ryan T Strachan, Julia K L Walker   +2 more
doaj   +1 more source

Select G-Protein-Coupled Receptors Modulate Agonist-Induced Signaling via a ROCK, LIMK, and β-Arrestin 1 Pathway

Cell Reports, 2013
G-protein-coupled receptors (GPCRs) are typically present in a basal, inactive state but, when bound to an agonist, activate downstream signaling cascades. In studying arrestin regulation of opioid receptors in dorsal root ganglia (DRG) neurons, we find that agonists of delta opioid receptors (δORs) activate cofilin through Rho-associated coiled-coil ...
Mittal, N, Roberts, K, Pal, K, Bentolila, LA, Fultz, E, Minasyan, A, Cahill, C, Pradhan, A, Conner, D, DeFea, K, Evans, C, Walwyn, W   +11 more
openaire   +6 more sources

GPR54 regulates ERK1/2 activity and hypothalamic gene expression in a Gα(q/11) and β-arrestin-dependent manner. [PDF]

PLoS ONE, 2010
G protein-coupled receptor 54 (GPR54) is a G(q/11)-coupled 7 transmembrane-spanning receptor (7TMR). Activation of GPR54 by kisspeptin (Kp) stimulates PIP(2) hydrolysis, Ca(2+) mobilization and ERK1/2 MAPK phosphorylation.
Jacob M Szereszewski, Macarena Pampillo, Maryse R Ahow, Stefan Offermanns, Moshmi Bhattacharya, Andy V Babwah   +5 more
doaj   +1 more source

Endothelial β‐arrestins regulate mechanotransduction by the type II bone morphogenetic protein receptor in primary cilia

Pulmonary Circulation, 2022
Modulation of endothelial cell behavior and phenotype by hemodynamic forces involves many signaling components, including cell surface receptors, intracellular signaling intermediaries, transcription factors, and epigenetic elements.
Saejeong Park, Zhiyuan Ma, Georgia Zarkada, Irinna Papangeli, Sarin Paluri, Nour Nazo, Felix Rivera‐Molina, Derek Toomre, Sudarshan Rajagopal, Hyung J. Chun   +9 more
doaj   +1 more source

A method for biomarker measurements in peripheral blood mononuclear cells isolated from anxious and depressed mice: β-arrestin 1 protein levels in depression and treatment

Frontiers in Pharmacology, 2013
A limited number of biomarkers in the central and peripheral systems which are known may be useful for diagnosing major depressive disorders and predicting the effectiveness of antidepressant treatments.
Indira eMENDEZ-DAVID, Zeina eEL-ALI, Rene eHEN, Bruno eFALISSARD, Emmanuelle eCORRUBLE, Alain M GARDIER, Saadia eKERDINE-ROMER, Denis Joseph DAVID   +7 more
doaj   +1 more source

The endocytosis of oxidized LDL via the activation of the angiotensin II type 1 receptor

iScience, 2021
Summary: Arrestin-dependent activation of a G-protein-coupled receptor (GPCR) triggers endocytotic internalization of the receptor complex. We analyzed the interaction between the pattern recognition receptor (PRR) lectin-like oxidized low-density ...
Toshimasa Takahashi, Yibin Huang, Koichi Yamamoto, Go Hamano, Akemi Kakino, Fei Kang, Yuki Imaizumi, Hikari Takeshita, Yoichi Nozato, Satoko Nozato, Serina Yokoyama, Motonori Nagasawa, Tatsuo Kawai, Masao Takeda, Taku Fujimoto, Kazuhiro Hongyo, Futoshi Nakagami, Hiroshi Akasaka, Yoichi Takami, Yasushi Takeya, Ken Sugimoto, Herbert Y. Gaisano, Tatsuya Sawamura, Hiromi Rakugi   +23 more
doaj   +1 more source

β-Arrestin-Mediated Signaling Improves the Efficacy of Therapeutics

Journal of Pharmacological Sciences, 2012
β-Arrestins (β-arrestin-1 and β-arrestin-2) were first identified as proteins that have the ability to desensitize G protein-coupled receptors (GPCRs). However, it has recently been found that β-arrestins can activate signaling pathways independent of G ...
Islam A.A.E.-H. Ibrahim, Hitoshi Kurose
doaj   +1 more source