β-arrestin-1 and β-arrestin-2 Restrain MRGPRX2-Triggered Degranulation and ERK1/2 Activation in Human Skin Mast Cells [PDF]
Frontiers in Allergy, 2022 As a novel receptor that efficiently elicits degranulation upon binding to one of its numerous ligands, MRGPRX2 has moved to the center of attention in mast cell (MC) research.
Zhao Wang +12 more
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The β-blocker Nebivolol Is a GRK/β-arrestin biased agonist. [PDF]
PLoS ONE, 2013 Nebivolol, a third generation β-adrenoceptor (β-AR) antagonist (β-blocker), causes vasodilation by inducing nitric oxide (NO) production. The mechanism via which nebivolol induces NO production remains unknown, resulting in the genesis of much of the ...
Catherine E Erickson +8 more
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Data on the evaluation of the relation between β-arrestin 2 and YAP phosphorylation in patient-derived colon cancer organoids [PDF]
Data in Brief, 2022 The data presented in this article is related to a rapid communication entitled “β-arrestin 2 suppresses the activation of YAP by promoting LATS kinase activity”.
Minsuh Kim +5 more
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Agonist dependency of the second phase access of β-arrestin 2 to the heteromeric µ-V1b receptor [PDF]
Scientific Reports, 2021 During the development of analgesic tolerance to morphine, the V1b vasopressin receptor has been proposed to bind to β-arrestin 2 and the µ-opioid receptor to enable their interaction.
Nuttawadee Ngamlertwong +5 more
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Investigation of adenosine A1 receptor-mediated β-arrestin 2 recruitment using a split-luciferase assay [PDF]
Frontiers in Pharmacology, 2023 Background: Adenosine A1 receptor (A1AR) plays a prominent role in neurological and cardiac diseases and inflammatory processes. Its endogenous ligand adenosine is known to be one of the key players in the sleep–wake cycle.
Luisa Saecker +2 more
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β-arrestin 2 Is a Prognostic Factor for Survival of Ovarian Cancer Patients Upregulating Cell Proliferation [PDF]
Frontiers in Endocrinology, 2020 Establishing reliable prognostic factors as well as specific targets for new therapeutic approaches is an urgent requirement in advanced ovarian cancer. For several tumor entities, the ubiquitously spread scaffold protein β-arrestin 2, a multifunctional ...
Bastian Czogalla +17 more
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LSD-stimulated behaviors in mice require β-arrestin 2 but not β-arrestin 1 [PDF]
Scientific Reports, 2021 Recent evidence suggests that psychedelic drugs can exert beneficial effects on anxiety, depression, and ethanol and nicotine abuse in humans. However, their hallucinogenic side-effects often preclude their clinical use.
Ramona M. Rodriguiz +6 more
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Tertiary butylhydroquinone alleviated liver steatosis and increased cell survival via β-arrestin-2/PI3K/AKT pathway [PDF]
Iranian Journal of Basic Medical Sciences, 2021 Objective(s): This study aimed to evaluate the effects and the underlying mechanisms of tertiary butylhydroquinone (TBHQ) on diabetic liver steatosis and cell survival. Materials and Methods: We performed streptozocin injection and used a high-sugar-high-
Tian Zhu +9 more
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β-arrestin 2 quenches TLR signaling to facilitate the immune evasion of EPEC [PDF]
Gut Microbes, 2020 The protein translocated intimin receptor (Tir) from enteropathogenic Escherichia coli shares sequence similarity with the host cellular immunoreceptor tyrosine-based inhibition motifs (ITIMs).
Zijuan Chen +11 more
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Molecular mechanism of β-arrestin-2 pre-activation by phosphatidylinositol 4,5-bisphosphate [PDF]
EMBO ReportsPhosphorylated residues of G protein-coupled receptors bind to the N-domain of arrestin, resulting in the release of its C-terminus. This induces further allosteric conformational changes, such as polar core disruption, alteration of interdomain loops ...
Kiae Kim, Ka Young Chung
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