Results 121 to 130 of about 12,251 (147)

c‐Jun N‐terminal kinase 3 as a permissive regulator of β‐cell incretin responsiveness

Journal of Diabetes Investigation, Volume 17, Issue 6, Page 915-916, June 2026.
Yuji Yamazaki
wiley   +1 more source

Single‐Cell Sequencing Reveals That CCL2+ Adipose‐Derived Stem Cells Promote Diabetic Wound Healing Through the CCL2‐ACKR1 Signaling Axis

The FASEB Journal, Volume 40, Issue 9, 15 May 2026.
scRNA‐seq of human adipose and diabetic wounds revealed a CCL2+ ADSC subpopulation with high stemness and ECM‐enriched pathways. These cells serve as a signaling hub via TGFB1‐TGFBR1, IL34‐CSF1R, and CCL2‐ACKR1. Their exosomes (CCL2‐Exos), carrying CCL2, TGFB1, and IL34, accelerate diabetic wound healing in mice by promoting angiogenesis, collagen ...
Songyun Zhao, Wanying Chen, Kaibo Liu, Jiaheng Xie, Yanming Chen, Hao Dai, Zhongqiu Lu, Longwang Chen, Yucang He, Hua Yu, Liqun Li   +10 more
wiley   +1 more source

Arrestin Beta-2 in Prostate Cancer and its Relationship with Trace Elements

مجلة كلية الطب
Background: Prostate cancer (PCa) is the most prevalent non-cutaneous malignancy and the second-leading cause of cancer-relatedmortality among males.
Inaam H. Kadhim, Rawaa H. Ali, Mohammed B. Ismail   +2 more
doaj   +1 more source

β-arrestin/connexin 43 complex anchors ERKs outside the nucleus: a pre-requisite for bisphosphonate anti-apoptotic effect mediated by CX43/ERK in osteocytes [PDF]

, 2016
Bisphosphonates (BPs) anti-fracture ef cacy may be due in part to inhibition of osteocyte apoptosis. This effect requires opening of con- nexin (Cx) 43 hemichannels and phosphoryla- tion of the extracellular signal regulated kinases (ERKs).
Bellido, Teresita, Gortazar, Arancha R., Plotkin, Lilian I.   +2 more
core  

Molecular mechanism of β-arrestin-2 pre-activation by phosphatidylinositol 4,5-bisphosphate

EMBO Reports
Phosphorylated residues of G protein-coupled receptors bind to the N-domain of arrestin, resulting in the release of its C-terminus. This induces further allosteric conformational changes, such as polar core disruption, alteration of interdomain loops ...
Kiae Kim, Ka Young Chung
doaj   +1 more source

Helix-bundle and C-terminal GPCR domains differentially influence GRK-specific functions and β-arrestin-mediated regulation

Nature Communications
G protein-coupled receptors (GPCRs) orchestrate diverse physiological responses via signaling through G proteins, GPCR kinases (GRKs), and arrestins.
Edda S. F. Matthees, Raphael S. Haider, Laura Klement, Mona Reichel, Nina K. Blum, Verena Weitzel, Thimea Trüpschuch, Carla Ziegler, Julia Drube, Stefan Schulz, Carsten Hoffmann   +10 more
doaj   +1 more source

β-arrestin1 at the cross-road of endothelin-1 signaling in cancer [PDF]

, 2016

core   +1 more source

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Membrane phosphoinositides regulate GPCR-β-arrestin complex assembly and dynamics

Cell, 2022
John Janetzko, Brian K Kobilka
exaly  

GPCR-mediated β-arrestin activation deconvoluted with single-molecule precision

Cell, 2022
Wesley B Asher, Daniel S Terry, Alem W Kahsai   +2 more
exaly  

Plasma membrane preassociation drives β-arrestin coupling to receptors and activation

Cell, 2023
Maria Makarova, Davide Calebiro
exaly