Results 121 to 130 of about 29,855 (176)

Arrestin Beta-2 in Prostate Cancer and its Relationship with Trace Elements

مجلة كلية الطب
Background: Prostate cancer (PCa) is the most prevalent non-cutaneous malignancy and the second-leading cause of cancer-relatedmortality among males.
Inaam H. Kadhim, Rawaa H. Ali, Mohammed B. Ismail   +2 more
doaj   +1 more source

Heteroreceptor complexes and their allosteric receptor-receptor interactions in the central nervous system. Focus on examples from Dopamine D2 and Serotonin 5-HT1a receptors [PDF]

, 2018
GPCR interacting proteins (specially β- arrestin) and their receptor-protein interactions are also covered but their interactions with the allosteric receptor-receptor interactions in heteroreceptor complexes remain to be elucidated.
Corrales Ferro, Fidel
core   +1 more source

Control of the Mdm2-p53 signal loop by β-arrestin 2: The ins and outs. [PDF]

Oncotarget, 2021
Blondel-Tepaz E, Enslen H, Scott MGH.
europepmc   +1 more source

Modelling G protein-biased agonism using GLP-1 receptor C-terminal mutations

Molecular Metabolism
Background and aim: The glucagon-like peptide-1 receptor (GLP-1R) is a major therapeutic target for type 2 diabetes and obesity. Agonists showing bias in favour of G protein signalling over β-arrestin recruitment and GLP-1R internalisation, e.g ...
Hanh Duyen Tran, Yiming Zuo, Carissa Wong, Alice Pollard, Steve Bloom, Ben Jones   +5 more
doaj   +1 more source

A Novel Splice Variant of BCAS1 Inhibits β-Arrestin 2 to Promote the Proliferation and Migration of Glioblastoma Cells, and This Effect Was Blocked by Maackiain. [PDF]

Cancers (Basel), 2022
Kuo YH, Hung HS, Tsai CW, Chiu SC, Liu SP, Chiang YT, Shyu WC, Lin SZ, Fu RH.   +8 more
europepmc   +1 more source

Improved Split TEV GPCR β-arrestin-2 Recruitment Assays via Systematic Analysis of Signal Peptide and β-arrestin Binding Motif Variants. [PDF]

Biosensors (Basel), 2022
Wu Y, von Hauff IV, Jensen N, Rossner MJ, Wehr MC.   +4 more
europepmc   +1 more source

A β-Arrestin 2-Biased Dopamine Receptor Type 2 (DRD2) Agonist Is More Efficacious Than Cabergoline in Reducing Cell Proliferation in PRL-Secreting but Not in Non-Functioning Pituitary Tumor Cells. [PDF]

Cancers (Basel), 2023
Di Muro G, Mangili F, Esposito E, Barbieri AM, Catalano R, Treppiedi D, Marra G, Nozza E, Lania AGA, Ferrante E, Locatelli M, Arosio M, Peverelli E, Mantovani G.   +13 more
europepmc   +1 more source

Helix-bundle and C-terminal GPCR domains differentially influence GRK-specific functions and β-arrestin-mediated regulation

Nature Communications
G protein-coupled receptors (GPCRs) orchestrate diverse physiological responses via signaling through G proteins, GPCR kinases (GRKs), and arrestins.
Edda S. F. Matthees, Raphael S. Haider, Laura Klement, Mona Reichel, Nina K. Blum, Verena Weitzel, Thimea Trüpschuch, Carla Ziegler, Julia Drube, Stefan Schulz, Carsten Hoffmann   +10 more
doaj   +1 more source

β-arrestin-2 predicts the clinical response to β-blockers in cirrhotic portal hypertension patients: A prospective study. [PDF]

World J Hepatol, 2022
Lashen SA, Shamseya MM, Madkour MA, Abdel Salam RM, Mostafa SS.   +4 more
europepmc   +1 more source

β-arrestin-2 alleviates rheumatoid arthritis injury by suppressing NLRP3 inflammasome activation and NF- κB pathway in macrophages. [PDF]

Bioengineered, 2022
Cao F, Huang C, Cheng J, He Z.
europepmc   +1 more source