Results 51 to 60 of about 938,653 (156)

Preliminary study on the effect of parenteral naloxone, alone and in association with calcium gluconate, on bone healing in an ovine "drill hole" model system

BMC Musculoskeletal Disorders, 2007
Background Several diseases affect bone healing and physiology. Many drugs that are commonly used in orthopaedics as "analgesics" or anti-inflammatory agents impair bone healing.
Langhoff Jens D, Varasano Vincenzo, Valbonetti Luca, Mariscoli Massimo, Petrizzi Lucio, Von Rechenberg Brigitte   +5 more
doaj   +1 more source

Step into action: how reminders shape engagement in fitness apps

Economica, Volume 93, Issue 372, Page 1225-1259, October 2026.
Abstract Regular exercise offers well‐documented health benefits, and mobile applications are increasingly used to promote physical activity. In this study, we conduct a large‐scale randomized controlled trial with 20,187 users of the WeWard app in France to evaluate the effectiveness of different message framings and intervention durations on app ...
Beatrice Braut, Claire Mollier, Sarah Zaccagni   +2 more
wiley   +1 more source

The Skin‐Lightening Efficacy and Mechanisms of Botanical Extracts: A Comprehensive Review

Journal of Cosmetic Dermatology, Volume 25, Issue 10, October 2026.
ABSTRACT Background Skin pigmentation is regulated by a complex network involving melanogenesis, melanosome transfer, oxidative stress, environmental stimuli, and epidermal turnover. Botanical extracts and phytochemicals have attracted increasing interest as potential skin‐lightening agents. This review evaluates their efficacy, mechanisms, and safety.
Siting Yang, Mingning Ding, Chenglong Ye, Jingning Shen, Lihua Zhang, Anquan Yang, Lihao Gu   +6 more
wiley   +1 more source

Proopiomelanocortin (POMC)–β‐Endorphin System in the Rat Colon: Expression, Up Regulation by Stress, and Correlation With Stress‐Induced Visceral Analgesia

Neurogastroenterology &Motility, Volume 38, Issue 10, October 2026.
This study identified a functional proopiomelanocortin–β‐endorphin system in the rat colon. Peripheral CRF and repeated water avoidance stress increased colonic POMC expression, which was associated with reduced visceral pain. These findings suggest that, outside the pituitary, a CRF‐ and stress‐sensitive enteric POMC–β‐endorphin system may help ...
Pu‐Qing Yuan, Muriel Larauche, Vincent Wu, Yvette Taché   +3 more
wiley   +1 more source

TRPV4/NCX1 coupling regulates Ca2+‐dependent cholecystokinin secretion from enteroendocrine cells to involve the pathogenesis of irritable bowel syndrome‐diarrhea in male mice

Physiological Reports, Volume 14, Issue 20, October 2026.
ACh regulates the increase of intracellular Ca2+ signaling through TRPV4/NCX1 coupling, inducing CCK release, and participates in the pathogenesis of IBS‐D. Abstract Although stress can stimulate the vagus nerve via the brain–gut axis to induce enterohormone secretion from enteroendocrine cells (EECs), little is currently known about the roles of ion ...
Jianxin Wang, Xiongying Chen, Shuo Tong, Chengxin Qu, Wei Lu, Hui Dong   +5 more
wiley   +1 more source

Concentrations of free radicals and beta-endorphins in repeat breeder cows [PDF]

, 2007
Repeat breeding (RB) is one of the major problems that affect the reproductive efficiency and economy of milk production in dairy animals. So far, the etiopathogenesis of this pathology has not been defined completely.
RIZZO, ANNALISA, TRISOLINI C, MINOIA G, SCIORSCI, Raffaele Luigi, MANCA R   +4 more
core  

Comorbidity Mechanism and Management of Chronic Low Back Pain and Major Depressive Disorder: From Neural Circuit Remodeling to Precision Medicine

Brain and Behavior, Volume 16, Issue 9, September 2026.
ABSTRACT Objective This review systematically elaborates multi‐system interactive mechanisms underlying comorbid chronic low back pain (CLBP) and major depressive disorder (MDD), synthesizes recent advances in diagnosis, treatment, and management, and proposes precision medicine directions to address clinical challenges, including missed diagnosis ...
Lin Faqu, Lin Chenjuan, Xiang Xiangyin, Li Xin   +3 more
wiley   +1 more source

Electroacupuncture ameliorates inflammatory pain through CB2 receptor-dependent activation of the AMPK signaling pathway

Chinese Medicine
Background Chronic inflammatory pain is a pervasive condition, and electroacupuncture (EA) is an effective treatment, but its mechanisms are not fully understood. AMP-activated protein kinase (AMPK), a key energy sensor, is involved in pain relief and EA’
Yuye Lan, Xianghong Jing, Ziyu Zhou, Yiqing Rao, Kaichen Wang, Renjie Qin, Yisong Wu, Jingjing Sun, Ke Zhang, Xinyue Liu, Zixiao Wang, Jiahao Xu, Minzhen zhao, Xiao Cui Yuan, Yongmin Liu, Hong Zhang, Xuefei Hu, Huilin Pan, Tengfei Hou, Man Li   +19 more
doaj   +1 more source

Smoking Abstinence Elicits Hyperalgesia: Neural Mechanism, Clinical Implications, and Pharmacological Managements

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
The cycle between nicotine use and pain modulation. Cigarette smoking leads to nicotine entering the body, which binds to nicotinic acetylcholine receptors (nAChRs) in the brain, triggering the release of different neurotransmitters, including dopamine (DA), norepinephrine (NE), serotonin (5‐HT), and GABA.
Shan‐shan Hu, Chao‐feng Zhang, Battuvshin Lkhagvasuren, Di Wang   +3 more
wiley   +1 more source

Slaughter of cattle without stunning: Questions related to pain, stress and endorphins

International audienceEEG studies have suggested that cattle perceive pain when bled without stunning. The present study on bleeding without stunning, compared cows that had received a local anaesthetic on the site of the bleeding cut (Lurocaine; Luro ...
Picgirard, Laurent, Aleyrangues, Xavier, Andanson, Stéphane, Paulmier, Valérie, Terlouw, Claudia, Durand, Denis   +5 more
core   +1 more source