Results 31 to 40 of about 3,185 (119)

In silico prediction of novel effective combinational treatment of chronic pain in individual patients: A joint white paper of the H2020 QSPainRelief consortium

British Journal of Pharmacology, EarlyView.
Abstract Opioids are prescribed widely for chronic pain despite well‐recognised risks and variable long‐term benefit, reflecting the lack of effective alternatives for many patients. Combination therapies offer a promising strategy to enhance efficacy whilst reducing side effects.
André Mouraux, Solenn Gousset, Beltrán Alvarez, Monica Baiula, Wouter Bakker, Andrea Bedini, Monir Bertayli, Divakar Budda, Robert Carr, Elisabetta Cuna, Óscar Díaz, Nina Donner, Jesús Giraldo, Geert‐Jan Groeneveld, Berfin Gülave, David Guydan, Hemme Hijma, Rafael Maldonado, Pedro Renault, Carlos Rinaudo, Jeroen Elaissaiss‐Schaap, Athan Spiros, Sara Stoeber, Petri Takkala, Daan van Valkengoed, Coen van Hasselt, Elizabeth (Liesbeth) CM de Lange   +26 more
wiley   +1 more source

Transcranial electrical stimulation in the treatment of peptic ulcer

Лечащий Врач
Background. Peptic ulcer disease is a chronic polyethological disease that occurs with the formation of ulcerative lesions, a tendency to progression and the formation of complications.
Dariya N. Tarasova, Vsevolod V. Skvortsov, Boleslav N. Levitan   +2 more
doaj   +1 more source

Peripheral κ opioid receptor in pain and inflammation: From molecular signalling and gene expression to drug discovery

British Journal of Pharmacology, EarlyView.
The κ opioid receptor (κ receptor, KOR) is a G protein‐coupled receptor with well established roles in analgesia and immune modulation. Although historically studied primarily in the central nervous system (CNS), growing evidence indicates that κ signalling in peripheral tissues plays an important role in regulating pain, inflammation and immune ...
Rumsha Khan, Elena C. A. Becker, Boglarka B. Bata, Christian W. Gruber   +3 more
wiley   +1 more source

Gut microbiota as a novel therapeutic target for eating disorders and obesity

British Journal of Pharmacology, EarlyView.
The graphical abstract highlights the bidirectional interaction between the gut microbiota and central homeostatic and hedonic mechanisms regulating food intake, which contributes to overweight and obesity. It also illustrates emerging microbiota‐based biomarkers and therapeutic strategies (including prebiotics, probiotics, postbiotics, synbiotics and ...
Solveiga Samulėnaitė, Victor Mathis, Emmanuel Darcq, Aurelijus Burokas, Elena Martín‐García, Rafael Maldonado   +5 more
wiley   +1 more source

DYNAMICS OF LEVEL B-ENDORPHINS AT MODELLING OF THE ISCHEMIC STROKE AT RATS

Кубанский научный медицинский вестник, 2014
The problem of treatment of the ischemic stroke (IS) is actual in modern medicine. In work an attempt of creation of model of cerebral ischemia at rats with possibility of application of TES-therapy is made.
A. I. Trofimenko, A. Kh. Kade, F. A. Nehaj, V. P. Lebedev, V. D. Levichkin, S. A. Zanin   +5 more
doaj  

Step into action: how reminders shape engagement in fitness apps

Economica, EarlyView.
Abstract Regular exercise offers well‐documented health benefits, and mobile applications are increasingly used to promote physical activity. In this study, we conduct a large‐scale randomized controlled trial with 20,187 users of the WeWard app in France to evaluate the effectiveness of different message framings and intervention durations on app ...
Beatrice Braut, Claire Mollier, Sarah Zaccagni   +2 more
wiley   +1 more source

ACTH suppression and adverse effects of cabergoline in horses with pituitary pars intermedia dysfunction

Equine Veterinary Education, EarlyView.
Summary Background The diagnosis and management of pituitary pars intermedia dysfunction (PPID) in horses includes evaluating abnormal plasma concentrations of adrenocorticotrophic hormone (ACTH). Treatment commonly includes the oral dopamine agonist pergolide mesylate, which suppresses the pathologic overproduction of ACTH.
A. Bracken, H. Tyra, M. Vetter, K. Kiger, S. Rao, L. Bass   +5 more
wiley   +1 more source

Programming of Dopaminergic Neurons by Early Exposure to Sex Hormones: Effects on Morphine-Induced Accumbens Dopamine Release, Reward, and Locomotor Behavior in Male and Female Rats

Frontiers in Pharmacology, 2019
Neonatal programming with sex hormones produces long-term functional changes in various tissues, including the brain. Previously, we demonstrated a higher content of dopamine and an increase in potassium-induced dopamine release in the nucleus accumbens ...
Victoria B. Velásquez, Gabriel A. Zamorano, Jonathan Martínez-Pinto, Christian Bonansco, Pablo Jara, Gonzalo E. Torres, Georgina M. Renard, Ramón Sotomayor-Zárate   +7 more
doaj   +1 more source

Use of Platelet‐Rich Fibrin (PRF) on Palatal Wound Healing: A Narrative Review With Clinical Recommendations

Journal of Periodontal Research, EarlyView.
Based on the available evidence, the application of platelet‐rich fibrin (PRF) following free gingival graft (FGG) and subepithelial connective tissue graft (SCTG) harvesting appears to be a promising approach for enhancing wound healing, minimizing postoperative complications, and reducing analgesic consumption. ABSTRACT This clinical narrative review
Nima Farshidfar, Paras Ahmad, Nathan Estrin, Yufeng Zhang, Richard J. Miron   +4 more
wiley   +1 more source

Potential health benefits of cold‐water immersion: the central role of PGC‐1α

The Journal of Physiology, EarlyView.
Abstract figure legend Cold‐water immersion (CWI) elicits autonomic, somato‐motoric (shivering thermogenesis), endocrine and metabolic, sensory transduction, and local biophysical effects that may converge on the transcriptional co‐activator PGC‐1α (centre).
Erich Hohenauer, Wafa Douzi, Johannes Burtscher   +2 more
wiley   +1 more source