The roles of CYP2C19 and CYP3A4 in the in vitro metabolism of β‐eudesmol in human liver: Reaction phenotyping and enzyme kinetics [PDF]
Pharmacology Research & Perspectives, 2023 β‐eudesmol is a major bioactive component of Atractylodes lancea (AL). AL has been developed as the capsule formulation of standardized AL extract for treating cholangiocarcinoma (CCA).
Nadda Muhamad, Kesara Na‐Bangchang
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Modulatory Effects of Atractylodin and β-Eudesmol on Human Cytochrome P450 Enzymes: Potential Drug-Drug Interactions [PDF]
Molecules, 2023 Atractylodin and β-eudesmol, the major bioactive compounds in Atractylodes lancea, are promising candidates for anti-cholangiocarcinoma. The inhibitory effects of both compounds on human rCYP1A2, rCYP2C9, rCYP2C19, rCYP2D6 and rCYP3A4 enzymes were ...
Artitaya Thiengsusuk +2 more
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Evaluation of heritability of β-eudesmol/hinesol content ratio in Atractylodes lancea De Candolle [PDF]
Hereditas, 2020 Background Atractylodes lancea De Candolle is a medicinal plant distributed in East Asia. Its rhizome has been used as an important crude drug in traditional Chinese and Japanese medicines for the treatment of numerous diseases and disorders.
Takahiro Tsusaka +3 more
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Effects of β-eudesmol and atractylodin on target genes and hormone related to cardiotoxicity, hepatotoxicity, and endocrine disruption in developing zebrafish embryos [PDF]
Science Progress, 2022 Atractylodes lancea, commonly known as Kod-Kamao in Thai, a traditional medicinal herb, is being developed for clinical use in cholangiocarcinoma.
Gyem Tshering +3 more
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β-Eudesmol induces the expression of apoptosis pathway proteins in cholangiocarcinoma cell lines [PDF]
Journal of Research in Medical Sciences, 2020 Background: Cholangiocarcinoma (CCA) is a neglected disease prevalent in developing countries with high burden and mortality rate, and there is no effective treatment.
Chisato Narahara +5 more
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Effect of β-Eudesmol on NQO1 suppression-enhanced sensitivity of cholangiocarcinoma cells to chemotherapeutic agents [PDF]
BMC Pharmacology and Toxicology, 2018 Background Cholangiocarcinoma (CCA), an epithelial malignancy of the biliary tree, is one of the aggressive cancers with poor prognosis and unsatisfactory response to chemotherapy with acquired resistance.
Pimradasiri Srijiwangsa +2 more
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A Bioeconomically Valuable Essential Oil from Baccharis sinuata Kunth in Southern Ecuador: Chemical Composition and Enantiomeric Profile [PDF]
PlantsThe present research describes the chemical composition and the enantiomeric profile of a spicy green aroma essential oil, distilled from the dry leaves of Baccharis sinuata Kunth (Asteraceae). The distillation yield was as high as 3.0% by weight.
Gianluca Gilardoni +3 more
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Analgesic and Anti-Inflammatory Potential of Essential Oil of Leaf: In Vivo and in Silico Studies
Natural Product Communications, 2021 The objective of our present study is to scrutinize the analgesic and anti-inflammatory potentials of essential oil of Eucalyptus camaldulensis leaf using different in vivo assay models at doses of 100, 200, and 400 mg/kg body weight.
Milon Mondal +14 more
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Frontiers in Plant Science, 2021 Previous chemotaxonomic studies of cannabis only focused on tetrahydrocannabinol (THC) dominant strains while excluded the cannabidiol (CBD) dominant strains and intermediate strains (THC ≈ CBD).
Dan Jin +6 more
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Plants, 2022 Our study’s overarching goal was to determine which O. basilicum cell suspensions approach yielded the most insecticidal and R. ferrugineus-inhibitory volatile secondary metabolites. After inoculation with Verticillium dahliae as an activator, the growth
Hossam Moustafa Darrag +3 more
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