Anti-inflammatory, antioxidant and anti-virulence roles of atractylodin in attenuating Listeria monocytogenes infection [PDF]
Frontiers in Immunology, 2022 BackgroundListeria monocytogenes (L. monocytogenes), as a pandemic foodborne pathogen, severely threatens food security and public health care worldwide, which evolves multiple bacterial virulence factors (such as listeriolysin O, LLO) for manipulating ...
Gejin Lu, Deng Xuming
exaly +6 more sources
Modulatory Effects of Atractylodin and β-Eudesmol on Human Cytochrome P450 Enzymes: Potential Drug-Drug Interactions [PDF]
Molecules, 2023 Atractylodin and β-eudesmol, the major bioactive compounds in Atractylodes lancea, are promising candidates for anti-cholangiocarcinoma. The inhibitory effects of both compounds on human rCYP1A2, rCYP2C9, rCYP2C19, rCYP2D6 and rCYP3A4 enzymes were ...
Kesara Na-Bangchang +2 more
exaly +6 more sources
Atractylodin alleviates nonalcoholic fatty liver disease by regulating Nrf2-mediated ferroptosis [PDF]
Heliyon, 2023 Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide. Oxidative stress is one of the main inducers of NAFLD.
Qingyan Ye +9 more
doaj +4 more sources
Atractylodin alleviates neuroinflammation and protects neurological function after ischemic stroke in association with reduced NLRP3 inflammasome activation [PDF]
Frontiers in NeurologyBackgroundNOD-like receptor protein 3 (NLRP3) inflammasome–driven neuroinflammation contributes to ischemic stroke injury. Atractylodin (ART) shows anti-inflammatory activity, but its neuroprotective potential and mechanistic links to NLRP3 signaling ...
Qingyao Ouyang +5 more
doaj +2 more sources
Frontiers in Pharmacology, 2021 In this study, we investigated the therapeutic effects and mechanism of atractylodin (ATL) on dextran sulfate sodium (DSS)-induced ulcerative colitis in mice.
Guosheng Cao, Yanju Liu, Kang Xu
exaly +3 more sources
Synergistic Effects of Atractylodes-Derived Sesquiterpenes and Polyacetylene on Chemotherapeutic Sensitivity in Cholangiocarcinoma: Impact on Transporter Gene Expression [PDF]
MoleculesAtractylodes lancea (AL) has been shown to be a promising candidate for the treatment of cholangiocarcinoma (CCA). The study explored the potential of atractylodin (AT) and β-eudesmol (BE) to chemosensitize the effects of standard chemotherapeutics in ...
Inthuon Kulma +2 more
doaj +2 more sources
Herbal Textual Research, Phytochemistry, Pharmacology and Toxicity of Atractylodis Rhizoma: A Comprehensive Review [PDF]
MoleculesThis review examines the historical development, ethnopharmacology, traditional applications, phytochemistry, and pharmacological attributes of Atractylodis Rhizoma (AR).
Jin Sun +6 more
doaj +2 more sources
Integrated transcriptome and metabolome analysis reveal the sesquiterpenoid biosynthesis mechanism of Atractylodes chinensis under drought stress [PDF]
Frontiers in Plant ScienceIntroductionAs a traditional Chinese medicine abundant in sesquiterpenoids, Atractylodes chinensis has various pharmacological activities. Nevertheless, the synthesis and metabolism mechanisms of its sesquiterpenoids under drought stress are still not ...
Ying Wu +6 more
doaj +2 more sources
Effects of β-eudesmol and atractylodin on target genes and hormone related to cardiotoxicity, hepatotoxicity, and endocrine disruption in developing zebrafish embryos [PDF]
Science Progress, 2022 Atractylodes lancea, commonly known as Kod-Kamao in Thai, a traditional medicinal herb, is being developed for clinical use in cholangiocarcinoma.
Gyem Tshering +3 more
doaj +2 more sources
Bioassay for total serum bioactivity of Atractylodes lancea [PDF]
Journal of Advanced Pharmaceutical Technology & Research, 2023 The study aimed to establish a bioassay for total bioactivity of Atractylodes lancea (AL) in human serum samples. Inhibition of bacterial growth (Staphylococcus aureus ATCC 25923) was assessed using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium ...
Kesara Na-Bangchang +3 more
doaj +2 more sources