Results 41 to 50 of about 477 (130)

The roles of CYP2C19 and CYP3A4 in the in vitro metabolism of β‐eudesmol in human liver: Reaction phenotyping and enzyme kinetics

Pharmacology Research &Perspectives, Volume 11, Issue 6, December 2023., 2023
CYP2C19 and CYP3A4 are major CYP enzymes in β‐eudesmol metabolism. As a component of AL, β‐eudesmol as a substrate and inhibitor of CYP2C19 and CYP3A4, has a high potential for drug‐drug interactions when AL is co‐administered with other herbs or conventional medicines. Abstract β‐eudesmol is a major bioactive component of Atractylodes lancea (AL).
Nadda Muhamad, Kesara Na‐Bangchang
wiley   +1 more source

A review of frequently used Kampo prescriptions. Part 3. Yokukansan

Traditional &Kampo Medicine, Volume 10, Issue 3, Page 197-223, December 2023., 2023
Abstract Background The source of yokukansan (YKS) is thought to be Baoying‐Jinjiang (Hoeikinkyōroku in Japanese) by Xue Ji. YKS was originally designed for children and indicated for spasms, clenching of teeth, digestive dysfunction due to mental instability, and insomnia. Key Findings YKS formula consists of seven types of crude drugs.
Hideaki Yamaguchi, Tetsuhiro Yoshino, Hiroaki Oizumi, Ryutaro Arita, Tatsuya Nogami, Shin Takayama   +5 more
wiley   +1 more source

Review of frequently used Kampo prescriptions: Part 4, Ninjin'yoeito

Traditional &Kampo Medicine, Volume 10, Issue 3, Page 224-252, December 2023., 2023
Abstract Background The source of ninjin'yoeito (NYT) is considered the ‘Formulary of Bureau of Taiping People's Welfare Pharmacy’, written around 1241–52 AD. NYT is used to treat patients with chronic fatigue, malaise with qi deficiency, and exhaustion of all five parenchymatous viscera with difficulty in recovering.
Shin Takayama, Seiwa Michihara, Yoko Kimura, Akinori Morinaga, Kyohei Miyakawa, Nobuhiko Tsushima, Kahori Otani, Atsuko Jinnai, Yuko Aso, Asako Okabayashi, Ryutaro Arita, Tatsuya Nogami, Akio Inui   +12 more
wiley   +1 more source

The effect of a pharmaceutical ghrelin agonist on lifespan in C57BL/6J male mice: A controlled experiment

Aging Cell, Volume 22, Issue 4, April 2023., 2023
In this experiment, C57BL/6J mice (N = 60/group, males) were tested for the influence of ghrelin agonism for perceived hunger, without caloric restriction, on longevity. Mice were fed a ghrelin agonist (LY444711; Eli Lilly) or placebo (Ctrl) until death. Treatment (GhrAg) animals were pair‐fed daily based on the group mean food intake consumed by Ctrls
Kathryn A. Kaiser, Inga Kadish, Thomas van Groen, Daniel L. Smith Jr., Stephanie Dickinson, Beate Henschel, Erik S. Parker, Andrew W. Brown, David B. Allison   +8 more
wiley   +1 more source

Comparative analysis of chemical constituents in Citri Exocarpium Rubrum, Citri Reticulatae Endocarpium Alba, and Citri Fructus Retinervus

Food Science &Nutrition, Volume 10, Issue 9, Page 3009-3023, September 2022., 2022
Comparative analysis of the chemical constituents in Citri Exocarpium Rubrum, Citri Reticulatae Endocarpium Alba, and Citri Fructus Retinervus. Abstract Citri Exocarpium Rubrum (CER), Citri Reticulatae Endocarpium Alba (CREA), and Citri Fructus Retinervus (CFR) are used as medicine and food, which derive from three different parts of the pericarp of ...
Wanling Yang, Mengshi Liu, Baizhong Chen, Jinrong Ning, Kanghui Wang, Yi Cai, Depo Yang, Guodong Zheng   +7 more
wiley   +1 more source

Effect of the Japanese herbal drug rikkunshito for the treatment of malnutrition in patients with chronic heart failure

Traditional &Kampo Medicine, Volume 9, Issue 2, Page 75-82, August 2022., 2022
Abstract Aim Although malnutrition is an important prognostic factor in patients with chronic heart failure (CHF), no effective treatment for malnutrition has been established. Rikkunshito (RKT) is a Japanese herbal drug that has been used in daily practice for patients with loss of appetite.
Masahiro Seo, Tetsuya Watanabe, Takahisa Yamada, Takashi Morita, Masato Kawasaki, Atsushi Kikuchi, Tsutomu Kawai, Jun Nakamura, Kiyomi Kayama, Kunpei Ueda, Daisuke Sakamoto, Takehiro Kogame, Yuto Tamura, Takeshi Fujita, Keisuke Nishigaki, Yuki Kokubu, Yuto Fukuda, Masatake Fukunami   +17 more
wiley   +1 more source

Repeated Yueju, But Not Fluoxetine, Induced Sustained Antidepressant Activity in a Mouse Model of Chronic Learned Helplessness: Involvement of CaMKII Signaling in the Hippocampus

Evidence-Based Complementary and Alternative Medicine, Volume 2022, Issue 1, 2022., 2022
Objective. Depression is characterized with long disease length, whereas one major disadvantage of current mainstream treatment of depression is a high rate of relapse and recurrence. A sustained antidepressant activity is proposed to facilitate the prevention of relapse/recurrence.
Zhilu Zou, Jiaru Huang, Qingqing Yang, Yuxuan Zhang, Bo Xu, Ping Wang, Gang Chen, Guoqi Zhu   +7 more
wiley   +1 more source

Cytotoxic activity and molecular targets of atractylodin in cholangiocarcinoma cells

Journal of Pharmacy and Pharmacology, 2019
Abstract Objectives To evaluate the cytotoxic activity of atractylodin and its potential effects on heme oxygenase (HO)-1 production, STAT1/3 phosporylation and major NF-κB protein expression in the cholangiocarcinoma-associated cell line CL-6. Methods
Vivek B Mathema, Wanna Chaijaroenkul, Kesara Na-Bangchang   +2 more
openaire   +2 more sources

Comparative transcriptome analysis reveals sesquiterpenoid biosynthesis among 1-, 2- and 3-year old Atractylodes chinensis

BMC Plant Biology, 2021
Background Atractylodes chinensis (DC.) Koidz is a well-known medicinal plant containing the major bioactive compound, atractylodin, a sesquiterpenoid.
Jianhua Zhao, Chengzhen Sun, Fengyu Shi, Shanshan Ma, Jinshuang Zheng, Xin Du, Liping Zhang   +6 more
doaj   +1 more source

Establishment of Thin Layer Chromatographic Fingerprints for the Quality Control of Chanthalila Preparation, A Thai Traditional Antipyretic Medicine

Journal of Health Science and Medical Research (JHSMR), 2023
Objective: This study aimed to develop thin layer chromatographic (TLC) fingerprints to control the quality of Chanthalila preparation (CP). Material and Methods: Twelve batches of reference CP were prepared from various sources and used as reference ...
Dujhathai Anekchai, Athip Sakunphueak
doaj   +1 more source