Results 61 to 70 of about 477 (130)

Current Insights of the Potential Plant Bioactive Compounds on Modulating the mTOR Signaling Pathway in Regulating Oncological Disorders

Phytotherapy Research, Volume 39, Issue 9, Page 4046-4059, September 2025.
ABSTRACT Deregulation of the mechanistic target of the rapamycin (mTOR) pathway plays an important role in cancer genesis and progression, making it an attractive target for cancer treatment. Disrupting the mTOR pathway contributes to uncontrolled cell growth, increased proliferation, and enhanced cell survival, all of which are hallmarks of cancer ...
Sonali Khanal, Manjusha Pillai, Md. Shimul Bhuia, Muhammad Torequl Islam, Onkar Sharma, Rachna Verma, Eugenie Nepovimova, Kamil Kuca, Dinesh Kumar, Raihan Chowdhury   +9 more
wiley   +1 more source

Determination and pharmacokinetic comparisons of atractylodin after oral administration of crude and processed Atractylodis rhizoma

Pharmacognosy Magazine, 2016
In traditional Chinese medicine, Atractylodis rhizoma is the dried rhizome of Atractylodes lancea (Thunb.) DC. or Atractylodes chinensis (DC.) Koidz. After being processed, the dryness of A. rhizoma decreased, and the function of tonifying spleen increased. Therefore, the processed A. rhizoma is the best choice of clinical application.
Xiao-Wen, Chang, Chen-Xi, Xu, Yu-Qiang, Liu, Cai, Qian   +3 more
openaire   +3 more sources

Boi‐Ogi‐To, a Traditional Japanese Kampo Medicine, Promotes Cellular Excretion of Chloride and Water by Activating Volume‐Sensitive Outwardly Rectifying Anion Channels

The FASEB Journal, Volume 39, Issue 9, 15 May 2025.
Boi‐ogi‐to (BOT) facilitates excretion of Cl− and water by activating VSOR anion channels. This study shows that BOT increases serum Na+ and Cl− levels in laboratory values and induces Cl− currents in human kidney epithelial HEK293T cells. Patch‐clamp studies confirmed that BOT activates LRRC8‐containing VSOR channels by translocating LRRC8A to the ...
Kaori Sato‐Numata, Taro Suzuki, Haruna Saito, Shotaro Kato, Ayako Sakai, Shuntaro Mori, Hajime Nakae, Hitoshi Hasegawa, Yasunobu Okada, Tomohiro Numata   +9 more
wiley   +1 more source

Influence of Nutrient (NPK) Factors on Growth, and Pharmacodynamic Component Biosynthesis of Atractylodes chinensis: An Insight on Acetyl-CoA Carboxylase (ACC), 3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGR), and Farnesyl Pyrophosphate Synthase (FPPS) Signaling Responses

Frontiers in Plant Science, 2022
In the planting of crops, especially medicinal plants, formula fertilization is important for improving the utilization rate of elements, soil quality, crop yield, and quality.
Jin Sun, Haoming Luo, Yuxin Jiang, Lijuan Wang, Chunping Xiao, Lili Weng   +5 more
doaj   +1 more source

Determination and tissue distribution comparisons of atractylodin after oral administration of crude and processed atractylodes rhizome

Pharmacognosy Magazine, 2017
Atractylodis rhizoma is one of the most often used drugs in traditional Chinese medicine. Stir frying with wheat bran is the most common processing method. To clarify the principle of processing, an experiment was carried out to compare the tissue distribution of typical constituent after oral administration of raw A.
Liu, Yang-Zhi, Liu, Yu-Qiang, Jia, Rui, Li, Jun, Chang, Xiao-Wen, Xu, Chen-Xi, Cai, Qian   +6 more
openaire   +3 more sources

Reactive Oxygen Species: From Tumorigenesis to Therapeutic Strategies in Cancer

Cancer Medicine, Volume 14, Issue 10, May 2025.
ABSTRACT Background Reactive oxygen species (ROS), a class of highly reactive molecules, are closely linked to the pathogenesis of various cancers. While ROS primarily originate from normal cellular processes, external stimuli can also contribute to their production. Cancer cells typically exhibit elevated ROS levels due to disrupted redox homeostasis,
Iqra Attique, Zahra Haider, Maha Khan, Samina Hassan, Mohamed Mohamed Soliman, Wisam Nabeel Ibrahim, Sumaira Anjum   +6 more
wiley   +1 more source

Spinal nerve transection‐induced upregulation of KDM4A in the dorsal root ganglia contributes to the development and maintenance of neuropathic pain via promoting CCL2 expression in rats

European Journal of Neuroscience, Volume 60, Issue 6, Page 5169-5188, September 2024.
The L5 SNT‐induced upregulation of KDM4A in DRG promoted the binding of p‐STAT1 with CCL2 promoter via inducing demethylation of H3K9me3. This combination enhanced CCL2 expression in the DRG and contributed to the pathogenesis of neuropathic pain following L5 SNT.
Liren Li, Zheng Ding, Fang Ma, Kai Zhang, Dan Lu, Hongmin Wang, Kangli Yang   +6 more
wiley   +1 more source

Atractylodin Suppresses Fibrotic Scar Formation and Enhances Functional Recovery Following Spinal Cord Injury

Journal of Integrative Neuroscience
Background: Fibrous scar formation significantly inhibits axonal regeneration and functional recovery following spinal cord injury (SCI).
Zhenwei Li, Chao Fang, Chengcheng Feng, Zuomeng Wu, Chenhao Zhao, Cailiang Shen   +5 more
doaj   +1 more source

A review of frequently used Kampo prescriptions. Part 5. Rikkunshito

Traditional &Kampo Medicine, Volume 11, Issue 2, Page 89-113, August 2024.
Abstract Background The source of rikkunshito (RKT) is thought to be Yixuezhengzhuan by Yu Tuan. RKT was originally designed for many patients to treat gastrointestinal symptoms such as abdominal bloating, discomfort, nausea, and anorexia. Key Findings RKT consists of eight types of crude drugs.
Mosaburo Kainuma, Yoshihiro Imazu, Hiroki Imazu, Koichiro Tanaka, Yasuhito Uezono, Kazunari Tominaga, Makoto Fujimoto   +6 more
wiley   +1 more source

Effect of drought on photosynthesis, total antioxidant capacity, bioactive component accumulation, and the transcriptome of Atractylodes lancea

BMC Plant Biology, 2021
Background Atractylodes lancea (Thunb.) DC, a medicinal herb belonging to the Asteraceae family, often faces severe drought stress during its growth.
Aqin Zhang, Mengxue Liu, Wei Gu, Ziyun Chen, Yuchen Gu, Lingfeng Pei, Rong Tian   +6 more
doaj   +1 more source